Results 61 to 70 of about 12,789,497 (387)

Apathy in Alzheimer's disease: Contribution to a clinical view on progression of dementia

Dementia & Neuropsychologia
In addition to cognitive impairment, apathy is increasingly recognized as an important neuropsychiatric syndrome in Alzheimer's disease (AD). Aims: To identify the relationship between dementia severity and apathy levels, and to discuss the association ...
Florindo Stella, Larissa Pires de Andrade, Thays Martins Vital, Flávia Gomes de Melo Coelho, Carla Manuela Crispim Nascimento, Salma Stephany Soleman Hernández   +5 more
doaj   +1 more source

FoxO3a and disease progression

World Journal of Biological Chemistry, 2014
The Forkhead box O (FoxO) family has recently been highlighted as an important transcriptional regulator of crucial proteins associated with the many diverse functions of cells. So far, FoxO1, FoxO3a, FoxO4 and FoxO6 proteins have been identified in humans.
Polla Hergert, Richard Seonghun Nho
openaire   +3 more sources

HERMIONE: a randomized Phase 2 trial of MM-302 plus trastuzumab versus chemotherapy of physician's choice plus trastuzumab in patients with previously treated, anthracycline-naïve, HER2-positive, locally advanced/metastatic breast cancer. [PDF]

, 2016
BackgroundHuman epidermal growth factor receptor 2 (HER2)-positive breast cancer is a particularly aggressive form of the disease, and ultimately progresses in patients with metastases on standard therapies.
Cortes, Javier, Hurvitz, Sara A, Krop, Ian E, Miller, Kathy, Molnar, Istvan, Reynolds, Joseph G, Riahi, Kaveh, Tripathy, Debu, Verma, Sunil, Wickham, Thomas J, Yardley, Denise A   +10 more
core   +2 more sources

Measuring coral disease lesions: a comparison of methodologies

Frontiers in Marine Science
The presence of stressors, particularly disease, on corals necessitates assessments of their severity in order to compare threat levels and to plan for impacts. Diseases in particular are often measured via the rate at which a lesion moves across a coral
Karen L. Neely
doaj   +1 more source

Impaired mitochondrial calcium efflux contributes to disease progression in models of Alzheimer’s disease

Nature Communications, 2019
Impairments in neuronal intracellular calcium (iCa2+) handling may contribute to Alzheimer’s disease (AD) development. Metabolic dysfunction and progressive neuronal loss are associated with AD progression, and mitochondrial calcium (mCa2+) signaling is ...
P. Jadiya, Devin W. Kolmetzky, D. Tomar, A. Di Meco, A. Lombardi, Jonathan P. Lambert, T. Luongo, M. H. Ludtmann, D. Praticò, J. Elrod   +9 more
semanticscholar   +1 more source

The current state of biomarker research for Friedreich's ataxia: a report from the 2018 FARA biomarker meeting [PDF]

, 2019
The 2018 FARA Biomarker Meeting highlighted the current state of development of biomarkers for Friedreich's ataxia. A mass spectroscopy assay to sensitively measure mature frataxin (reduction of which is the root cause of disease) is being developed ...
Blair, Ian A., Farmer, Jennifer, Hersch, Steven, Larkindale, Jane, Lynch, David R., Napierala, Jill, Napierala, Marek, Payne, R. Mark, Subramony, Sub H.   +8 more
core   +1 more source

Prediction of disease progression, treatment response and dropout in chronic obstructive pulmonary disease (COPD). [PDF]

, 2014
Drug development in chronic obstructive pulmonary disease (COPD) has been characterised by unacceptably high failure rates. In addition to the poor sensitivity in forced expiratory volume in one second (FEV1), numerous causes are known to contribute to ...
Danhof, M, Della Pasqua, O, Facius, A, Maas, HJ, Musuamba, FT, Teutonico, D, Yang, S   +6 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Clinically feasible automated MRI volumetry of the brain as a prognostic marker in subjective and mild cognitive impairment

Frontiers in Neurology
Background/aimsThe number of patients suffering from cognitive decline and dementia increases, and new possible treatments are being developed. Thus, the need for time efficient and cost-effective methods to facilitate an early diagnosis and prediction ...
Rachel Amland, Rachel Amland, Rachel Amland, Geir Selbæk, Geir Selbæk, Geir Selbæk, Anne Brækhus, Anne Brækhus, Anne Brækhus, Trine H. Edwin, Knut Engedal, Anne-Brita Knapskog, Ellen Regine Olsrud, Karin Persson, Karin Persson   +14 more
doaj   +1 more source

Classification of Pediatric Asthma: From Phenotype Discovery to Clinical Practice

Frontiers in Pediatrics, 2018
Advances in big data analytics have created an opportunity for a step change in unraveling mechanisms underlying the development of complex diseases such as asthma, providing valuable insights that drive better diagnostic decision-making in clinical ...
Ceyda Oksel, Sadia Haider, Sara Fontanella, Clement Frainay, Clement Frainay, Adnan Custovic   +5 more
doaj   +1 more source