Results 61 to 70 of about 3,016,766 (291)

Serial intravascular ultrasound assessment of coronary atherosclerosis progression and remodeling [PDF]

, 2008
Cardiovascular disease is a major cause of morbidity and mortality in countries with western lifestyle. Reliable quantitative assessment of the extent of coronary atherosclerosis during the natural history of coronary artery disease and following ...
Hartmann, Marc
core   +3 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Leflunomide plus low-dose prednisone in patients with progressive IgA nephropathy: a multicenter, prospective, randomized, open-labeled, and controlled trial

Renal Failure, 2021
Background Immunoglobulin A nephropathy (IgAN) is the most common cause of glomerulonephritis worldwide, and the optimal approach to its treatment remains a significant challenge.
Zhaohui Ni, Zhen Zhang, Zanzhe Yu, Fuming Lu, Changlin Mei, Xiaoqiang Ding, Weijie Yuan, Wei Zhang, Gengru Jiang, Min Sun, Liqun He, Yueyi Deng, Huihua Pang, Jiaqi Qian   +13 more
doaj   +1 more source

Discovery of a Novel Leaf Rust (Puccinia recondita) Resistance Gene in Rye (Secale cereale L.) Using Association Genomics

Cells, 2021
Leaf rust constitutes one of the most important foliar diseases in rye (Secale cereale L.). To discover new sources of resistance, we phenotyped 180 lines belonging to a less well-characterized Gülzow germplasm at three field trial locations in Denmark ...
Nikolaj Meisner Vendelbo, Khalid Mahmood, Pernille Sarup, Mogens S. Hovmøller, Annemarie Fejer Justesen, Peter Skov Kristensen, Jihad Orabi, Ahmed Jahoor   +7 more
doaj   +1 more source

Favorable outcome of early treatment of new onset child and adolescent migraine-implications for disease modification. [PDF]

, 2009
There is evidence that the prevalence of migraine in children and adolescents may be increasing. Current theories of migraine pathophysiology in adults suggest activation of central cortical and brainstem pathways in conjunction with the peripheral ...
A Ferrari, A Fox, A Hershey, A Hershey, AI Scher, AI Scher, Alan M. Rapoport, B Bille, B. L. Peterlin, C Waeber, C Wober, D D’Amico, D Loder, D Marcus, DC Haas, Fred D. Sheftell, G Fuller, HF Boardman, I Abu-Arefeh, JA Charles, JA Charles, James A. Charles, JF Fries, JL Brandes, K Ahoen, KMA Welch, L Pageler, L Peterlin, M Fanicullace, MA Kabbouche, Marielle A. Kabbouche, MC Kruit, ME Bigal, NH Raskin, NT Mathew, NT Mathew, P Winner, R Burstein, R Burstein, R Hering-Hanit, R Lipton, R Monastero, R Petrella, S Solomon, SD Silberstein, SD Silberstein, SL Linder, SL Linder, SL Linder, Steven L. Linder, W Split, WF Stewart, WF Stewart   +52 more
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Stage-specific action of matrix metalloproteinases influences progressive hereditary kidney disease. [PDF]

, 2006
BackgroundGlomerular basement membrane (GBM), a key component of the blood-filtration apparatus in the in the kidney, is formed through assembly of type IV collagen with laminins, nidogen, and sulfated proteoglycans.
Cosgrove, Dominic, Kalluri, Raghu, Khurana, Mona, Rao, Velidi H, Rougier, Jean-Philippe, Shield, Charles F, Werb, Zena, Werner, Michelle C, Zeisberg, Michael   +8 more
core   +3 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Rad27/FEN1 prevents accumulation of Okazaki fragments and ribosomal DNA copy number changes

FEBS Letters, EarlyView.
The budding yeast Rad27 is a structure‐specific endonuclease. Here, the authors reveal that Rad27 is crucial for maintaining the stability of the ribosomal RNA gene (rDNA) region. Rad27 deficiency leads to the accumulation of Okazaki fragments and changes in rDNA copy number.
Tsugumi Yamaji, Yuko Katayama, Nanase Arata, Mariko Sasaki   +3 more
wiley   +1 more source

A Nomogram Model of Radiomics and Satellite Sign Number as Imaging Predictor for Intracranial Hematoma Expansion

Frontiers in Neuroscience, 2020
BackgroundWe aimed to construct and validate a nomogram model based on the combination of radiomic features and satellite sign number for predicting intracerebral hematoma expansion.MethodsA total of 129 patients from two institutions were enrolled in ...
Wen Xu, Zhongxiang Ding, Yanna Shan, Wenhui Chen, Zhan Feng, Peipei Pang, Qijun Shen   +6 more
doaj   +1 more source