Results 61 to 70 of about 12,637,526 (357)

Label-free high-throughput photoacoustic tomography of suspected circulating melanoma tumor cells in patients in vivo [PDF]

, 2020
Significance: Detection and characterization of circulating tumor cells (CTCs), a key determinant of metastasis, are critical for determining risk of disease progression, understanding metastatic pathways, and facilitating early clinical intervention.
Cornelius, Lynn A., Hai, Pengfei, Li, Yang, Qu, Yuan, Shmuylovich, Leonid, Wang, Lihong V., Zhu, Liren   +6 more
core   +1 more source

HERMIONE: a randomized Phase 2 trial of MM-302 plus trastuzumab versus chemotherapy of physician's choice plus trastuzumab in patients with previously treated, anthracycline-naïve, HER2-positive, locally advanced/metastatic breast cancer. [PDF]

, 2016
BackgroundHuman epidermal growth factor receptor 2 (HER2)-positive breast cancer is a particularly aggressive form of the disease, and ultimately progresses in patients with metastases on standard therapies.
Cortes, Javier, Hurvitz, Sara A, Krop, Ian E, Miller, Kathy, Molnar, Istvan, Reynolds, Joseph G, Riahi, Kaveh, Tripathy, Debu, Verma, Sunil, Wickham, Thomas J, Yardley, Denise A   +10 more
core   +2 more sources

Apathy in Alzheimer's disease: Contribution to a clinical view on progression of dementia

Dementia & Neuropsychologia
In addition to cognitive impairment, apathy is increasingly recognized as an important neuropsychiatric syndrome in Alzheimer's disease (AD). Aims: To identify the relationship between dementia severity and apathy levels, and to discuss the association ...
Florindo Stella, Larissa Pires de Andrade, Thays Martins Vital, Flávia Gomes de Melo Coelho, Carla Manuela Crispim Nascimento, Salma Stephany Soleman Hernández   +5 more
doaj   +1 more source

Measuring coral disease lesions: a comparison of methodologies

Frontiers in Marine Science
The presence of stressors, particularly disease, on corals necessitates assessments of their severity in order to compare threat levels and to plan for impacts. Diseases in particular are often measured via the rate at which a lesion moves across a coral
Karen L. Neely
doaj   +1 more source

The current state of biomarker research for Friedreich's ataxia: a report from the 2018 FARA biomarker meeting [PDF]

, 2019
The 2018 FARA Biomarker Meeting highlighted the current state of development of biomarkers for Friedreich's ataxia. A mass spectroscopy assay to sensitively measure mature frataxin (reduction of which is the root cause of disease) is being developed ...
Blair, Ian A., Farmer, Jennifer, Hersch, Steven, Larkindale, Jane, Lynch, David R., Napierala, Jill, Napierala, Marek, Payne, R. Mark, Subramony, Sub H.   +8 more
core   +1 more source

Genomic Correlates of Disease Progression and Treatment Response in Prospectively Characterized Gliomas

Clinical Cancer Research, 2019
Purpose: The genomic landscape of gliomas has been characterized and now contributes to disease classification, yet the relationship between molecular profile and disease progression and treatment response remain poorly understood.
P. Jonsson, Andrew L. Lin, R. Young, Natalie Distefano, D. Hyman, Bob T. Li, M. Berger, A. Zehir, M. Ladanyi, D. Solit, A. Arnold, Z. Stadler, D. Mandelker, M. Goldberg, J. Chmielecki, Maryam Pourmaleki, Shahiba Q. Ogilvie, S. Chavan, Andrew T. McKeown, Malbora Manne, A. Hyde, K. Beal, T. Yang, C. Nolan, E. Pentsova, A. Omuro, I. Gavrilovic, T. Kaley, E. Diamond, J. Stone, C. Grommes, A. Boire, M. Daras, Anna F Piotrowski, Alexandra M Miller, P. Gutin, T. Chan, V. Tabar, C. Brennan, M. Rosenblum, L. Deangelis, I. Mellinghoff, B. Taylor   +42 more
semanticscholar   +1 more source

Predicting Severe Disease and Critical Illness on Initial Diagnosis of COVID-19: Simple Triage Tools

Frontiers in Medicine, 2022
RationaleThis study was conducted to develop, validate, and compare prediction models for severe disease and critical illness among symptomatic patients with confirmed COVID-19.MethodsFor development cohort, 433 symptomatic patients diagnosed with COVID ...
Lutfi Ali S. Kurban, Sharina AlDhaheri, Abdulbaset Elkkari, Ramzi Khashkhusha, Shaikha AlEissaee, Amna AlZaabi, Mohamed Ismail, Omran Bakoush   +7 more
doaj   +1 more source

Prediction of disease progression, treatment response and dropout in chronic obstructive pulmonary disease (COPD). [PDF]

, 2014
Drug development in chronic obstructive pulmonary disease (COPD) has been characterised by unacceptably high failure rates. In addition to the poor sensitivity in forced expiratory volume in one second (FEV1), numerous causes are known to contribute to ...
Danhof, M, Della Pasqua, O, Facius, A, Maas, HJ, Musuamba, FT, Teutonico, D, Yang, S   +6 more
core   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Predict Disease Progression With Reaction Rate Equation Modeling of Multimodal MRI and PET

Frontiers in Aging Neuroscience, 2018
Neurodegenerative dementia often has multiple types of underlying pathology, for example, beta-amyloid, misfolded tau, chronic neuroinflammation and neurodegeneration may coexist in Alzheimer’s disease.
Li Su, Li Su, Yujing Huang, Yi Wang, James Rowe, John O’Brien   +5 more
doaj   +1 more source