Results 91 to 100 of about 13,391,079 (299)

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Purine Metabolism and Hexosamine Biosynthetic Pathway Abnormalities in Diarrheal Weaned Piglets Identified Using Metabolomics

Animals
Post-weaning diarrhea significantly contributes to the high mortality in pig production, but the metabolic changes in weaned piglets with diarrhea remain unclear.
Mingyu Wang, Qin Zhong, Huailu Xin, Bing Yu, Jun He, Jie Yu, Xiangbing Mao, Zhiqing Huang, Yuheng Luo, Junqiu Luo, Hui Yan, Aimin Wu, Junning Pu, Ping Zheng   +13 more
doaj   +1 more source

Association between insulin resistance and the development of cardiovascular disease

Cardiovascular Diabetology, 2018
For many years, cardiovascular disease (CVD) has been the leading cause of death around the world. Often associated with CVD are comorbidities such as obesity, abnormal lipid profiles and insulin resistance.
V. Ormazábal, Soumyalekshmi Nair, Omar Elfeky, C. Aguayo, C. Salomon, F. Zúñiga   +5 more
semanticscholar   +1 more source

Expression and DNA methylation of 20S proteasome subunits as prognostic and resistance markers in cancer

Molecular Oncology, EarlyView.
Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla, Simone Venz, Ruslan Al‐Ali, Martin Wendlandt, Mandy Radefeldt, Elke Krüger   +5 more
wiley   +1 more source

Probiotic Lactobacillus rhamnosus GG improves insulin sensitivity and offspring survival via modulation of gut microbiota and serum metabolite in a sow model

Journal of Animal Science and Biotechnology
Background Sows commonly experience insulin resistance in late gestation and lactation, causing lower feed intake and milk production, which can lead to higher mortality rates in newborn piglets. The probiotic Lactobacillus rhamnosus GG (LGG) is known to
Tianle Gao, Ran Li, Liang Hu, Quanfang Hu, Hongmei Wen, Rui Zhou, Peiqiang Yuan, Xiaoling Zhang, Lingjie Huang, Yong Zhuo, Shengyu Xu, Yan Lin, Bin Feng, Lianqiang Che, De Wu, Zhengfeng Fang   +15 more
doaj   +1 more source

Future directions in breeding for disease resistance in aquaculture species

, 2017
Infectious disease is a major constraint for all species produced via aquaculture. The majority of farmed fish and shellfish production is based on stocks with limited or no selective breeding.
R. Houston
semanticscholar   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Risk of metabolic and vascular disease in South Asians: potential mechanisms for increased insulin resistance [PDF]

, 2008
Lesley Hall, Naveed Sattar, Jason M. R. Gill   +2 more
openalex   +1 more source

Effects of Corn Naturally Contaminated with Aflatoxins on Performance, Calcium and Phosphorus Metabolism, and Bone Mineralization of Broiler Chicks

The Journal of Poultry Science, 2014
The objective of this study was to investigate the effects of corn naturally contaminated with low levels of aflatoxins (AF) on performance, calcium (Ca) and phosphorus (P) metabolism, and bone mineralization in broilers.
Shiping Bai, Leilei Wang, Yuheng Luo, Xumei Ding, Jun Yang, Jie Bai, Keying Zhang, Jianping Wang   +7 more
doaj   +1 more source

The durable wheat disease resistance gene Lr34 confers common rust and northern corn leaf blight resistance in maize

Plant Biotechnology Journal, 2016
Summary Maize (corn) is one of the most widely grown cereal crops globally. Fungal diseases of maize cause significant economic damage by reducing maize yields and by increasing input costs for disease management.
Justine Sucher, Rainer Boni, Ping Yang, P. Rogowsky, Heike Büchner, Christine Kastner, J. Kumlehn, S. Krattinger, B. Keller   +8 more
semanticscholar   +1 more source