Results 71 to 80 of about 8,489,060 (313)

The genetics of infectious disease susceptibility: has the evidence for epistasis been overestimated? [PDF]

, 2013
Interactions amongst genes, known as epistasis, are assumed to make a substantial contribution to the genetic variation in infectious disease susceptibility, but this claim is controversial.
Ebert, Dieter, Dieter Ebert, Hall, Matthew, Matthew D Hall, Hall, Matthew D.   +4 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Dietary resistant starch ameliorating lipopolysaccharide-induced inflammation in meat ducks associated with the alteration in gut microbiome and glucagon-like peptide 1 signaling

Journal of Animal Science and Biotechnology, 2022
Background Consumption of resistant starch (RS) has been associated with various intestinal and systemic health benefits, but knowledge of its effects on intestinal health and inflammatory response in stressed birds is limited.
Simeng Qin, Weiqiang Bai, Todd J. Applegate, Keying Zhang, Gang Tian, Xuemei Ding, Shiping Bai, Jianping Wang, Li Lv, Huanwei Peng, Yue Xuan, Quifeng Zeng   +11 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Composition, Influencing Factors, and Effects on Host Nutrient Metabolism of Fungi in Gastrointestinal Tract of Monogastric Animals

Animals
Intestinal fungi, collectively referred to as mycobiota, constitute a small (0.01–2%) but crucial component of the overall intestinal microbiota. While fungi are far less abundant than bacteria in the gut, the volume of an average fungal cell is roughly ...
Xiaofeng Deng, Hua Li, Aimin Wu, Jun He, Xiangbing Mao, Zhaolai Dai, Gang Tian, Jingyi Cai, Jiayong Tang, Yuheng Luo   +9 more
doaj   +1 more source

Effect of organic acids on growth performance, intestinal morphology, and immunity of broiler chickens with and without coccidial challenge

AMB Express, 2021
A total of 360-day-old broiler chicks were allocated into six groups in 2 (Coccidial challenge or not) × 3 (dietary treatments) factorial design. Three dietary treatments including: basic diet, basic diet plus organic acids (OAs) in drinking water, and ...
Ahsan Mustafa, Shiping Bai, Qiufeng Zeng, Xuemei Ding, Jianping Wang, Yue Xuan, Zhuowei Su, Keying Zhang   +7 more
doaj   +1 more source

Melanism and disease resistance in insects.

, 2001
There is growing evidence that insects in high-density populations invest relatively more in pathogen resistance than those in low-density populations (i.e. density-dependent prophylaxis).
Wilson, K., Cotter, S. C., Pell, Judith K., Pell, J. K., Reeson, Andrew Francis, Cotter, Sheena C., Reeson, A. F., Wilson, Kenneth, Reeson, Andrew F.   +8 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Prevotella copri alleviates diarrhea in weaning piglets through gut microbiota modulation and arachidonic acid–AHR–NRF2 pathway activation

Journal of Animal Science and Biotechnology
Background Diarrhea remains a major health concern in both young animals and humans. Prevotella spp., a dominant commensal genus in the healthy porcine gut, becomes increasingly abundant following weaning, suggesting a potential role during this critical
Cong Lan, Wen Ren, Aimin Wu, Bing Yu, Jun He, Yuheng Luo, Daiwen Chen   +6 more
doaj   +1 more source