Results 91 to 100 of about 3,031,744 (313)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Selection for Disease Resistance

Journal of Dairy Science, 1989
Approaches to disease control are prioritized. Genetic improvement could reduce need for treatment and culling but would not reduce the need for proper management and sanitation. Results of several studies indicate that disease incidence and cost increases with selection for milk yield.
openaire   +2 more sources

Genetic diseases conferring resistance to infectious diseases

Genes & Diseases, 2015
This review considers available evidence for mechanisms of conferred adaptive advantages in the face of specific infectious diseases. In short, we explore a number of genetic conditions, which carry some benefits in adverse circumstances including exposure to infectious agents.
Withrock, Isabelle C., Anderson, Stephen J., Jefferson, Matthew A., McCormack, Garrett R., Mlynarczyk, Gregory S.A., Nakama, Aron, Lange, Jennifer K., Berg, Carrie A., Acharya, Sreemoyee, Stock, Matthew L., Lind, Melissa S., Luna, K.C., Kondru, Naveen C., Manne, Sireesha, Patel, Bhavika B., de la Rosa, Bierlein M., Huang, Kuei-Pin, Sharma, Shaunik, Hu, Hilary Z., Kanuri, Sri Harsha, Carlson, Steve A.   +20 more
openaire   +2 more sources

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Use of cornstarch or fermented soybean meal in lactation diet improved sows’ nutrient utilization and litter performance during lactation [PDF]

Animal Bioscience
Objective This study investigated the effects of cornstarch (CS) and fermented soybean meal (FSM) substitutions for conventional corn and soybean meal, respectively, on sow’s performance, nutrient digestibility, milk composition, and oxidative status ...
Li Zhe, Hongmei Wen, Fangyuan Chen, Yong Zhuo, Yan Lin, Shengyu Xu, Xuemei Jiang, Lingjie Huang, Lianqiang Che, Bin Feng, De Wu, Takele Feyera, Zhengfeng Fang   +12 more
doaj   +1 more source

Genomic selection on cacao for disease resistance : S04T08 [PDF]

, 2013
Under favorable conditions, diseases can cause losses up to 100% in cacao. Breeding has been the most effective strategy in reducing these losses. However, breeding is limited by the: a) long generation time; b) large tree size (9 m2/tree); c) multiple ...
Clément, Didier, Gramacho, Karina Peres, Lanaud, Claire, Lopes, Uilson Vanderlei, Monteiro, Wilson Reis, Phillips-Mora, Wilbert, Pires, José Luis   +6 more
core  

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Assessment of disease in low-input cereal cropping systems and variety trials [PDF]

, 2005
Disease assessment is the basis for describing disease resistance characteristics of commercial varieties in national variety lists for all crops where disease is considered a problem.
Hovmøller, M.S., Pinnschmidt, H., Willas, J., Østergård, H.   +3 more
core  

Genetic mapping, synteny, and physical location of two loci for Fusarium oxysporum f. sp. tracheiphilum race 4 resistance in cowpea [Vignaunguiculata (L.) Walp]. [PDF]

, 2013
Fusarium wilt is a vascular disease caused by the fungus Fusariumoxysporum f.sp. tracheiphilum (Fot) in cowpea [Vignaunguiculata (L.) Walp]. In this study, we mapped loci conferring resistance to Fot race 4 in three cowpea RIL populations: IT93K-503-1 ...
Close, Timothy J, Ehlers, Jeffery D, Li, Guojing, Pottorff, Marti O, Roberts, Philip A   +4 more
core   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source