Results 91 to 100 of about 8,489,060 (313)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Use of cornstarch or fermented soybean meal in lactation diet improved sows’ nutrient utilization and litter performance during lactation [PDF]

Animal Bioscience
Objective This study investigated the effects of cornstarch (CS) and fermented soybean meal (FSM) substitutions for conventional corn and soybean meal, respectively, on sow’s performance, nutrient digestibility, milk composition, and oxidative status ...
Li Zhe, Hongmei Wen, Fangyuan Chen, Yong Zhuo, Yan Lin, Shengyu Xu, Xuemei Jiang, Lingjie Huang, Lianqiang Che, Bin Feng, De Wu, Takele Feyera, Zhengfeng Fang   +12 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Ncm-1 gene for resistance to Cucumber mosaic virus in yellow lupin (Lupinus luteus): molecular studies and marker development [PDF]

, 2012
Cucumber mosaic virus (CMV) is an important virus pathogen of lupins in Australia which causes serious yield losses of up to 60% in epidemic years. In commercially grown lupin (Lupinus angustifolius and L.
Li, Dora
core  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Integrated gut metagenomic and muscle proteomic analysis reveals the role of dietary fermented extruded brewers’ spent grain in enhancing pork quality through the gut-muscle axis

Journal of Animal Science and Biotechnology
Background The fact that feeding pigs with probiotic-fermented agricultural by-products improves pork quality has been repeatedly demonstrated and widely applied, but the underlying mechanisms remain unclear.
Yang Liu, Yueqin Xie, Jianqi Yang, Yu Deng, Dongyun Liu, Junlei Chang, Jiayong Tang, Hua Zhao, Xiaoling Chen, Gang Tian, Guangmang Liu, Jingyi Cai, Gang Jia   +12 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Biochemical and molecular studies of some aspects of disease resistance in potato (solanum tuberosum L.) [PDF]

, 1999
Disease problems in crop plants are still a major threat to the agro-industry worldwide. Various strategies have been developed and evaluated in recent years.
Abdullah, Mohd Pu'ad, Abdullah, M.P.
core  

Analysis of non-TIR NBS-LRR resistance gene analogs in Musa acuminata Colla: Isolation, RFLP marker development, and physical mapping [PDF]

, 2008
Background Many commercial banana varieties lack sources of resistance to pests and diseases, as a consequence of sterility and narrow genetic background. Fertile wild relatives, by contrast, possess greater variability and represent potential sources of
Baurens, Franc-Christophe, Santos, Candice M.R., Bertioli David J, Souza Júnior, Manoel T., Pappas Junior, Georgios, Pappas Júnior, Georgios J., Miller, Roberto Neil Gerard, Alves, P.C., Souza, Manoel, Baurens Franc C, Miller Robert NG, Togawa, Roberto Coiti, Togawa, R., Alves Paulo C, Togawa Roberto C, Santos Candice MR, Baurens, F.C., Souza, M.T., Alves, Paulo C., Santos, C.R., Martins, N.F., Miller, R.N., Alves, P.C.M., Togawa, Roberto, C., Martins, Natalia F., Souza Manoel T, Pappas, G., Miller, Robert N.G., Bertioli, D., Martins, Natalia, Martins Natalia F, Pappas Georgios J, Bertioli, David J., Togawa, Roberto C.   +33 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source