Results 81 to 90 of about 8,964,528 (267)

Global burden of bacterial antimicrobial resistance 1990-2021: a systematic analysis with forecasts to 2050 [PDF]

Background: Antimicrobial resistance (AMR) poses an important global health challenge in the 21st century. A previous study has quantified the global and regional burden of AMR for 2019, followed with additional publications that provided more detailed ...
GBD, 2021 Antimicrobial Resistance Collaborators, GBD 2021 Antimicrobial Resistance Collaborators   +1 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease

, 2021
Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of insulin resistance. The term insulin resistance is very wide and could affect different proteins involved in insulin signaling, as well as other mechanisms.
Beatriz Jiménez, Manuel Benito, Benito De Las Heras, Manuel R., Carlos Guillén, Jiménez, Beatriz, Marqués, Patricia, Burillo Maldonado, Jesús, González-Blanco, Carlos, Carlos González-Blanco, Guillén Viejo, Carlos, Jesús Burillo, Patricia Marqués   +11 more
core   +1 more source

Integrated gut metagenomic and muscle proteomic analysis reveals the role of dietary fermented extruded brewers’ spent grain in enhancing pork quality through the gut-muscle axis

Journal of Animal Science and Biotechnology
Background The fact that feeding pigs with probiotic-fermented agricultural by-products improves pork quality has been repeatedly demonstrated and widely applied, but the underlying mechanisms remain unclear.
Yang Liu, Yueqin Xie, Jianqi Yang, Yu Deng, Dongyun Liu, Junlei Chang, Jiayong Tang, Hua Zhao, Xiaoling Chen, Gang Tian, Guangmang Liu, Jingyi Cai, Gang Jia   +12 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Special Issue: Antimicrobial Resistance in Livestock

, 2020
Antimicrobial resistance threatens the health of both humans and livestock as antimicrobials become continually less effective for controlling infectious disease [...
Kim Stanford
core   +1 more source

A genome-wide genetic map of NB-LRR disease resistance loci in potato [PDF]

, 2011
Like all plants, potato has evolved a surveillance system consisting of a large array of genes encoding for immune receptors that confer resistance to pathogens and pests.
Erin Bakker, Gerard van der Linden, Rene Klein-Lankhorst, Eck, H.J., van, Arens, M.J.B., Mariëlle Muskens, Visser, R.G.F., Vossen, E.A.G., van der, Muskens, M., Jaap Bakker, Jan de Boer, Bakker, E.H., Theo Borm, Roeland van Ham, Prins, J.C.P., Vossen, J., Goverse, A., Richard Visser, Aska Goverse, Uenk, G.E., Herman van Eck, Geert Smant, Pjotr Prins, Borm, T.J.A., Ham, R., van der, Bakker, J., Edwin van der Vossen, Marjon Arens, Boer, J.M., de, Gerda Uenk, Klein Lankhorst, R.M., Jack Vossen, Linden, C.G., van der   +32 more
core   +1 more source