Results 61 to 70 of about 1,811,797 (317)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Endoplasmic Reticulum Stress Contributes to Intestinal Injury in Intrauterine Growth Restriction Newborn Piglets

Animals
Intrauterine growth retardation (IUGR) in piglets is associated with a high rate of morbidity and mortality after birth due to gut dysfunction, and the underlying mechanisms remain poorly understood.
Tingting Fang, Gang Tian, Daiwen Chen, Jun He, Ping Zheng, Xiangbing Mao, Hui Yan, Bing Yu   +7 more
doaj   +1 more source

Melanism and disease resistance in insects.

, 2001
There is growing evidence that insects in high-density populations invest relatively more in pathogen resistance than those in low-density populations (i.e. density-dependent prophylaxis).
Wilson, K., Cotter, S. C., Pell, Judith K., Pell, J. K., Reeson, Andrew Francis, Cotter, Sheena C., Reeson, A. F., Wilson, Kenneth, Reeson, Andrew F.   +8 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Rational consideration of Akkermansia muciniphila targeting intestinal health: advantages and challenges

npj Biofilms and Microbiomes, 2022
As one of the promising next-generation probiotics (NGPs), Akkermansia muciniphila, a well-known mucin-degrading bacterium, has been proven to be closely related to the metabolic diseases of its human host. However, the role of A. muciniphila in the host’
Yuheng Luo, Cong Lan, Hua Li, Qingyuan Ouyang, Fanli Kong, Aimin Wu, Zhihua Ren, Gang Tian, Jingyi Cai, Bing Yu, Jun He, André-Denis G. Wright   +11 more
doaj   +1 more source

Analysis of non-TIR NBS-LRR resistance gene analogs in Musa acuminata Colla: Isolation, RFLP marker development, and physical mapping [PDF]

, 2008
Background Many commercial banana varieties lack sources of resistance to pests and diseases, as a consequence of sterility and narrow genetic background. Fertile wild relatives, by contrast, possess greater variability and represent potential sources of
Baurens, Franc-Christophe, Santos, Candice M.R., Bertioli David J, Souza Júnior, Manoel T., Pappas Junior, Georgios, Pappas Júnior, Georgios J., Miller, Roberto Neil Gerard, Alves, P.C., Souza, Manoel, Baurens Franc C, Miller Robert NG, Togawa, Roberto Coiti, Togawa, R., Alves Paulo C, Togawa Roberto C, Santos Candice MR, Baurens, F.C., Souza, M.T., Alves, Paulo C., Santos, C.R., Martins, N.F., Miller, R.N., Alves, P.C.M., Togawa, Roberto, C., Martins, Natalia F., Souza Manoel T, Pappas, G., Miller, Robert N.G., Bertioli, D., Martins, Natalia, Martins Natalia F, Pappas Georgios J, Bertioli, David J., Togawa, Roberto C.   +33 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Unlocking the power of swine gut bacteria: newly isolated Blautia strain and its metabolites inhibit the replication of Salmonella Typhimurium in macrophages and alleviate DSS-induced colitis in mice

Journal of Animal Science and Biotechnology
Background Inflammatory bowel disease is a significant health concern for both humans and large-scale farm animals. In the quest for effective alternatives to antibiotics, next-generation probiotics (NGPs) have emerged as a promising option.
Jiatong Wei, Yang Liu, Hua Li, Ze Lu, Yanjiao Liu, Yifan Zhang, Cong Lan, Aimin Wu, Jun He, Jingyi Cai, Gang Tian, Daiwen Chen, Bing Yu, Zhiqing Huang, Ping Zheng, Xiangbing Mao, Jie Yu, Junqiu Luo, Hui Yan, Jiayong Tang, Huifen Wang, Quyuan Wang, Yuheng Luo   +22 more
doaj   +1 more source

Dietary resistant starch ameliorating lipopolysaccharide-induced inflammation in meat ducks associated with the alteration in gut microbiome and glucagon-like peptide 1 signaling

Journal of Animal Science and Biotechnology, 2022
Background Consumption of resistant starch (RS) has been associated with various intestinal and systemic health benefits, but knowledge of its effects on intestinal health and inflammatory response in stressed birds is limited.
Simeng Qin, Weiqiang Bai, Todd J. Applegate, Keying Zhang, Gang Tian, Xuemei Ding, Shiping Bai, Jianping Wang, Li Lv, Huanwei Peng, Yue Xuan, Quifeng Zeng   +11 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source