Results 41 to 50 of about 932,172 (297)

Prevention of Cryptosporidium and GIARDIA at the Human/Gorilla/Livestock Interface

Frontiers in Public Health, 2018
Mountain gorillas (Gorilla beringei beringei) are critically endangered and found in Bwindi Impenetrable Forest and Virunga Volcanoes. Habitat destruction, high human population growth rates, poverty, and disease are threatening the survival of mountain ...
Gladys Kalema-Zikusoka, Stephen Rubanga, Birungi Mutahunga, Ryan Sadler   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

RELATIONSHIP BETWEEN CLIMATE VARIABLES AND DENGUE INCIDENCE IN WEST INDONESIA

Jurnal Kedokteran Diponegoro
Background: Dengue fever is a major public health problem, especially in heavily populated metropolitan areas like Palembang City, Indonesia. Gaining insight into the impact of climatic conditions on the dynamics of dengue transmission is essential for ...
Ahmad Ghiffari, Ratika Febriani, Galuh Pratama Mynanda, Thia Prameswarie   +3 more
doaj   +1 more source

Multifocal Avian Influenza (H5N1) Outbreak

Emerging Infectious Diseases, 2007
During March 2006, an outbreak of highly pathogenic avian influenza (H5N1) occurred in multiple poultry farms in Israel. The epidemiologic investigation and review of outbreak mitigation efforts uncovered gaps in planning for and containing the outbreak,
Ran D. Balicer, Shmuel Reznikovich, Elyakum Berman, Michael Pirak, Amnon Inbar, Shimon Pokamunski, Itamar Grotto   +6 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Different Levels of Endemicity of Cutaneous Leishmaniasis in Brazil

Zoonotic Diseases
Brazil is the first of the 12 priority countries in Latin America with the highest number of cases of American cutaneous leishmaniasis (ACL). This study estimated the prevalence of ACL in Brazil and classified the states according to the different levels
Dilceu Silveira Tolentino Júnior, Heberson Teixeira da Silva, Alessandro Martins Ribeiro, Ana Mécia Ribeiro Amador, Bruno Oliveira Souza e Silva, Bárbara Mendes Guimarães, Manuella Botelho Laure Nogueira, Hellen Karine Campos Teixeira, Eliseu Miranda de Assis   +8 more
doaj   +1 more source

Quantifying the potential pathogens transmission of the blowflies (Diptera: Calliphoridae)

Memorias do Instituto Oswaldo Cruz, 2003
To quantify the potential capability of transporting and passing infective pathogens of some blowflies (Diptera: Calliphoridae), Mihályi's danger-index was calculated for seven species.
Marcelo A Maldonado, Néstor Centeno
doaj   +1 more source

Influenza outbreak, disease transmission rate and mortality risk in the United States (2021 to 2050 Projection) [PDF]

, 2021
Peter Mudiaga Etaware
openalex   +1 more source