Results 91 to 100 of about 47,212 (310)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Digital Twins in Radiology

, 2022
A digital twin is a virtual model developed to accurately reflect a physical thing or a system. In radiology, a digital twin of a radiological device enables developers to test its characteristics, make alterations to the design or materials, and test ...
Filippo Pesapane, Penco, Silvia, Enrico Cassano, Pesapane, Filippo, Cassano, Enrico, Silvia Penco, Nicosia, Luca, Luca Nicosia, Rotili, Anna, Anna Rotili   +9 more
core   +1 more source

Birth weight discordance and adverse neonatal outcomes in appropriately grown premature twins

Heliyon
Objective: This study aimed to analyze the clinical characteristics of birth weight discordant twins (BWDT) who were premature and appropriate-for-gestational-age or large-for-gestational-age.
Ling Yang, Yan Zhou, Jie Qiu, Nacheng Lin, Ning Gu, Yimin Dai   +5 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota [PDF]

, 2011
Objective The gut microbiota, which is considered a causal factor in metabolic diseases as shown best in animals, is under the dual influence of the host genome and nutritional environment. This study investigated whether the gut microbiota per se, aside
Klopp, Christophe, Amar, Jacques, Aurelie Waget, Baylac, Audrey, Waget, Aurélie, Klopp, Pascale, Theodorou, Vassilia, Elodie Luche, Iacovoni, Jason, Francoise Ouarné, Bouloumié, Anne, Jerome Mariette, Pascale Klopp, Klopp, Christophe,, Bergé, Mathieu, Mariette, Jérôme, J., Klopp, Pascal, Remy Burcelin, Serino, Matteo, Burcelin, Rémy, Valet, Philippe, Roques, Christine, Bouchez, Olivier, Matteo Serino, Mathieu Bergé, Jacques Amar, Claire Cenac, Philippe Valet, Monsan, Pierre, Jerome Lluch, Sandra Gres, Mariette, Jérôme,, Christophe Klopp, Christine Roques, Pierre Monsan, Mariette, Jérôme, Jason Iacovoni, Vassilia Théodorou, Cenac, Claire, Lluch, Jérôme, Audrey Baylac, Gres, Sandra, Ouarné, Françoise, Anne Bouloumié, Luche, Elodie, Olivier Bouchez   +45 more
core   +1 more source

The role of epigenetic mechanisms and processes in autoimmune disorders

Biologics: Targets & Therapy, 2012
Judith M Greer, Pamela A McCombeThe University of Queensland, UQ Centre for Clinical Research, Brisbane, Queensland, AustraliaAbstract: The lack of complete concordance of autoimmune disease in identical twins suggests that nongenetic factors play a ...
Greer JM, McCombe PA
doaj  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Snoring in twins

, 1995
Snoring is a prerequisite for obstructive sleep apnoea (OSA) and is known to run in families. Recent studies have provided sufficient evidence for a familial predisposition to OSA.
Marca, G.Della, Zucconi, M., Castronovo, V., Smirne, S., Ferini-Strambi, L., Oldani, A., Calori, G., Gallus, G.   +7 more
core   +1 more source

Hospitalization in Adolescence and Young Adulthood Among Twins and Singletons : A Swedish Cohort Study of Subjects Born Between 1973 and 1983 [PDF]

, 2013
Children born with non-optimal birth characteristics — that is, are small for gestational age and/or preterm — have an increased risk for several long-term effects such as neurological sequelae and chronic disease.
Carstensen, John,, Bladh, Marie, Sydsjö, Gunilla, Sydsjö, Gunilla,, Josefsson, Ann,, Finnström, Orvar, Carstensen, John, Bladh, Marie,, Finnström, Orvar,, Josefsson, Ann   +9 more
core   +1 more source

Digital twins in dermatology, current status, and the road ahead

npj Digital Medicine
Digital twins, innovative virtual models synthesizing real-time biological, environmental, and lifestyle data, herald a new era in personalized medicine, particularly dermatology. These models, integrating medical-purpose Internet of Things (IoT) devices,
Hossein Akbarialiabad, Amirmohammad Pasdar, Dédée F. Murrell   +2 more
doaj   +1 more source