Results 51 to 60 of about 45,703 (295)

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The Necessity of Development and Implementation of Twins Registry in Iran

open access: yesمجله انفورماتیک سلامت و زیست پزشکی, 2018
Introduction: In the last three decades, national twins registries have been developed throughout the world with the aim of studying unique genetic characteristics and the possibility of determining the genotypic effects.
Hamidreza Abtahi   +2 more
doaj  

Building digital twins of the human immune system: toward a roadmap

open access: yesnpj Digital Medicine, 2022
Digital twins, customized simulation models pioneered in industry, are beginning to be deployed in medicine and healthcare, with some major successes, for instance in cardiovascular diagnostics and in insulin pump control.
R. Laubenbacher   +9 more
doaj   +1 more source

Coeliac disease in identical twin infants [PDF]

open access: yesPostgraduate Medical Journal, 1981
Summary A pair of monozygous twins had coeliac disease in infancy, and all of their family carried the HLA-B8 antigen. Both genetic and environmental factors were involved in the aetiology.
C, Lord, G A, MacGregor
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Pili torti and multiple facial milia as an expression of ectodermal dysplasia in monozygotic twins

open access: yesPrzegląd Dermatologiczny, 2014
Introduction . Genodermatoses – congenital diseases with diverse clinical presentation – are caused by ectodermal defects. pili torti and milia may be features of these defects. Concomitantly these symptoms are present in rare genodermatoses: Bazex-Dupre-
Monika Sikorska   +3 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

open access: yesFEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo   +4 more
wiley   +1 more source

The role and implications of mammalian cellular circadian entrainment

open access: yesFEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Gene Expression Profiles from Disease Discordant Twins Suggest Shared Antiviral Pathways and Viral Exposures among Multiple Systemic Autoimmune Diseases. [PDF]

open access: yesPLoS ONE, 2015
Viral agents are of interest as possible autoimmune triggers due to prior reported associations and widely studied molecular mechanisms of antiviral immune responses in autoimmunity.
Lu Gan   +7 more
doaj   +1 more source

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