Twin Studies in Metabolic Diseases
Annals of Medicine, 1992 The traditional role of twin studies has been to assess the relative role of genetic factors as a first step in defining the genetic architecture of complex traits. This has been based on the realization that monozygotic pairs (MZ) share all their genes, while dizygotic pairs (DZ) share 50% of their genes on average.
M, Koskenvuo, J, Kaprio, K, Romanov
openaire +2 more sources
Digital twins for chronic lung diseases
European Respiratory ReviewDigital twins have recently emerged in healthcare. They combine advances in cyber–physical systems, modelling and computation techniques, and enable a bidirectional flow of information between the physical and virtual entities.
Apolline Gonsard +2 more
doaj +1 more source
Alzheimer's disease in one monozygotic twin [PDF]
Journal of Neurology, Neurosurgery & Psychiatry, 1972 A woman of 64 died after an illness lasting 15 years and characterized by a progressive amnesic syndrome followed by global dementia. The brain showed changes typical of Alzheimer's disease. Her monozygotic twin sister was clinically not affected and died two years later of carcinoma.
R, Hunter, A D, Dayan, J, Wilson
openaire +2 more sources
Building digital twins of the human immune system: toward a roadmap
npj Digital Medicine, 2022 Digital twins, customized simulation models pioneered in industry, are beginning to be deployed in medicine and healthcare, with some major successes, for instance in cardiovascular diagnostics and in insulin pump control.
R. Laubenbacher +9 more
doaj +1 more source
Genetic analysis of rare disorders: Bayesian estimation of twin concordance rates [PDF]
, 2012 Twin concordance rates provide insight into the possibility of a genetic background for a disease. These concordance rates are usually estimated within a frequentistic framework. Here we take a Bayesian approach.
Berg, S.M. van den, Hjelmborg, J.
core +5 more sources
Coeliac disease in identical twin infants [PDF]
Postgraduate Medical Journal, 1981 Summary A pair of monozygous twins had coeliac disease in infancy, and all of their family carried the HLA-B8 antigen. Both genetic and environmental factors were involved in the aetiology.
C, Lord, G A, MacGregor
openaire +2 more sources
The Necessity of Development and Implementation of Twins Registry in Iran
مجله انفورماتیک سلامت و زیست پزشکی, 2018 Introduction: In the last three decades, national twins registries have been developed throughout the world with the aim of studying unique genetic characteristics and the possibility of determining the genotypic effects.
Hamidreza Abtahi +2 more
doaj
Neonatal DNA methylation profile in human twins is specified by a complex interplay between intrauterine environmental and genetic factors, subject to tissue-specific influence [PDF]
, 2012 Comparison between groups of monozygotic (MZ) and dizygotic (DZ) twins enables an estimation of the relative contribution of genetic and shared and nonshared environmental factors to phenotypic variability.
Alisch, Reid S. +14 more
core +1 more source
Pili torti and multiple facial milia as an expression of ectodermal dysplasia in monozygotic twins
Przegląd Dermatologiczny, 2014 Introduction . Genodermatoses – congenital diseases with diverse clinical presentation – are caused by ectodermal defects. pili torti and milia may be features of these defects. Concomitantly these symptoms are present in rare genodermatoses: Bazex-Dupre-
Monika Sikorska +3 more
doaj +1 more source
Strikingly higher frequency in centenarians and twins of mtDNA mutation causing remodeling of replication origin in leukocytes [PDF]
, 2003 The presence of a genetic component in longevity is well known. Here, the association of a mtDNA mutation with a prolonged life span in humans was investigated.
Asin-Cayuela, Jordi +9 more
core