Results 91 to 100 of about 147,692 (317)

Homologous expression and purification of human HAX‐1 for structural studies

open access: yesFEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Case Report: Generalized motor tonic seizures characterized by paroxysmal fast activity on EEG in a Tonkinese cat

open access: yesFrontiers in Veterinary Science
Epilepsy is one of the most common neurological disorders in cats, affecting 1%−2% of the feline population. Feline epilepsy can often be managed with standard anti-seizure medications, which typically offer moderate to good seizure control.
Laura Brewińska   +5 more
doaj   +1 more source

Epidemiology of Thyroid Diseases of Dogs and Cats

open access: yesVeterinary Clinics of North America: Small Animal Practice, 1994
Data regarding the epidemiology of the thyroid diseases in companion animals are sparse. Published studies providing information regarding the epidemiology of canine hypothyroidism and thyroid neoplasia and feline hyperthyroidism are summarized. Future studies should seek to refine diagnoses, include control animals for comparison, and target the ...
openaire   +2 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

open access: yesFEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan   +6 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

open access: yesFEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani   +7 more
wiley   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Iron parameters analysis in dogs with myxomatous mitral valve disease

open access: yesBMC Veterinary Research
Background Myxomatous mitral valve disease (MMVD) is the most common acquired cardiovascular disease in small breed dogs. In contrast to human patients with heart failure (HF), iron deficiency (ID) prevalence in dogs with MMVD is weakly known.
Ewa Kumiega   +3 more
doaj   +1 more source

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