Results 241 to 250 of about 158,715 (307)

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Disease modelling with in vitro vascularised organoids. [PDF]

Dis Model Mech
Kan C, Liu L, Sugimura R.
europepmc   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source

First fatal human bloodstream infection caused by <i>Macrococcus caseolyticus</i> subsp. <i>caseolyticus</i> in China: genomic insights into virulence and antimicrobial resistance. [PDF]

Front Cell Infect Microbiol
Shi L, Ruan Y, Wang X, Xu J, Pu J, Zhang Y, Lu Z.   +6 more
europepmc   +1 more source

Epigenetic Silencing of RFX7 Defines a Transcriptional Axis Linking Lactate Metabolism to Immune Checkpoint Therapy in Glioblastoma

Advanced Science, EarlyView.
Glioblastoma (GBM) exhibits RFX7 silencing via promoter hypermethylation, which downregulates PIK3IP1 to activate PI3K/AKT signaling, increase lactate accumulation, and enhance histone H4K12 lactylation. This lactylation upregulates PD‐L1/CSF1 expression and drives the immunosuppressive microenvironment formation.
Liying Han, Jinpeng Zhou, Gang Zhu, Fan Chen, Leiyang Li, Wenxing Cui, Fang Sun, Tian Feng, Yue Zhang, Qiang Wang, Shuoyao Ma, Chengxuan Guo, Ziwen Zhang, Kai Wang, Jiahui Wang, Liangbo Wang, Wencong Li, Chenyi Yuan, Haixiao Liu, Liang Wang, Yan Qu   +20 more
wiley   +1 more source

Newcastle disease virus hijacks chicken red blood cells as dissemination vehicles with concomitant adsorption-mediated cell death. [PDF]

Vet Res
Wang Q, Qu Y, Sun Y, Liao Y, Qiu X, Tan L, Song C, Tang N, Chen L, Ren T, Ding C.   +10 more
europepmc   +1 more source

Pasteurellosis in a spiny-tailed iguana (Ctenosaura pectinata). [PDF]

J Vet Med Sci
Yoshida Y, Suzuki M, Une Y.
europepmc   +1 more source

Occludin-mediated barrier dysfunction and its role in cardiovascular and cerebrovascular pathogenesis. [PDF]

Front Cardiovasc Med
Xu W, Xu T, Long H, Jiang Q, Liao W.
europepmc   +1 more source

Cross-shaped nanoporous poly(methyl methacrylate) fibers for selective adsorption of β₂-microglobulin and other middle-molecular-weight proteins. [PDF]

Int J Artif Organs
Fujieda H, Osuka T, Nakada M, Kanda J, Kishikawa T, Sakaguchi H, Fujita M, Osabe M, Sugata T, Sugaya H, Ueno Y.   +10 more
europepmc   +1 more source