Results 101 to 110 of about 121,573 (346)
Adult Incidence in the Russian European Arctic with Developed Mining and Metallurgical Industry (en)
Российская Арктика, 2019 The purpose of the research. The research aims to assess the adult incidence within the mining complex in the Murmansk Region (the Russian Arctic). Materials and methods.
A. N. Nikanov +4 more
doaj +1 more source
Advanced Science, EarlyView.Current preclinical studies of AAV‐mediated gene therapy explore different strategies based on the characteristics of inner ear diseases. For genetic hearing loss, approaches include the replacement of a “good gene,” removal of a “bad gene,” or direct correction of mutations through base editing.
Fan Wu +7 more
wiley +1 more source
What do Portuguese people die of? [PDF]
, 2018 Nowadays, in developed countries as Portugal, deaths are essentially concentrated at old and very old ages, but it is still rather important to identify main causes of death (CODs).
Ribeiro, Filipe
core
Cryptic Splicing of GAP43 mRNA is a Novel Hallmark of TDP‐43‐Associated ALS and AD
Advanced Science, EarlyView.TDP‐43 dysfunction disrupts RNA processing, inducing cryptic exon 4a1 inclusion in GAP43 and reducing its protein levels. This aberrant splicing impairs axonal regeneration and contributes to neurodegeneration in ALS and AD. RNA‐seq of patient brains reveals GAP43 downregulation and 4a1 upregulation, identifying cryptic exon 4a1 as a potential ...
Mingming Yang +9 more
wiley +1 more source
Socioeconomic Heterogeneity in the Effect of Health Shocks on Earnings. Evidence from Population-Wide Data on Swedish Workers [PDF]
In this paper, we estimate socioeconomic heterogeneity in the effect of unexpected health shocks on labor market outcomes, using register-based data on the entire population of Swedish workers.
Lundborg, Petter +2 more
core
Advanced Science, EarlyView.This study reveals a novel mechanism of resistance to DNA hypomethylating agents (HMAs) in acute myeloid leukemia (AML), and identifies all‐trans retinoic acid (ATRA) and tamibarotene (TAM) as potent agents that overcome HMA resistance by reactivating the interferon anticancer immune response. The findings offer promising therapeutic strategies for HMA‐
Xueqin Chen +18 more
wiley +1 more source
The Effect of Drug Vintage on Survival: Micro Evidence from Puerto Rico's Medicaid Program [PDF]
Using micro data on virtually all of the drugs and diseases of over 500,000 people enrolled in Puerto Rico's Medicaid program, we examine the impact of the vintage (original FDA approval year) of drugs used to treat a patient on the patient's 3-year ...
Frank R. Lichtenberg
core
Human Nervous System‐Based Biohybrid Robot‐On‐A‐Chip with Sensing Function for Toxicity Screening
Advanced Science, EarlyView.Human nervous system‐based biohybrid robot‐on‐a chip with eye function as sensing system in addition to brain/motor neuron/muscle functions is proposed. Upon light stimulation, the eye assembloid generates electrophysiological signals, which are transmitted through the cerebral organoid and motor neuron spheroid, inducing muscle movement.
Minkyu Shin +6 more
wiley +1 more source
Barnes Hospital Bulletin [PDF]
, 1970 https://digitalcommons.wustl.edu/bjc_barnes_bulletin/1060/thumbnail ...
core +1 more source
Engineered Cas12j‐8 is a Versatile Platform for Multiplexed Genome Modulation in Mammalian Cells
Advanced Science, EarlyView.Engineered through structure‐guided protein engineering, enCas12j‐8 significantly enhances the editing efficiency of compact Cas12j‐8 while maintaining high specificity. It enables efficient multiplexed genome editing and base editing using a single crRNA array, demonstrating broad applicability and therapeutic potential in genome engineering ...
Ru Meng +14 more
wiley +1 more source