Results 81 to 90 of about 122,730 (293)

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Characteristics of HLA and Cytokine Production in Patients with Diseases of the Genitourinary System

Health of Man
Immunogenetic diagnostics allows identifying individuals with a high degree of risk of developing certain diseases, and associative connections with the cytokine link of immunity to expand ideas about their immunogenesis to determine prognostic markers and its course. The objective: to evaluate the associative relationships between the HLA-phenotype of
Vozianov, Serhiy, Kolesnyk, Mykola, Driianska, Victoria, Shulyak, Oleksandr, Poroshina, Tetyana, Nurimanov, Kamil, Bondarenko, Yuri, Petryna, Olena, Savchenko, Viktoriya   +8 more
openaire   +4 more sources

Spontaneous Non‐Catalyzed Molecular Reactions and Interactions in the Human Body: Biomedical Implications

Advanced Science, EarlyView.
ABSTRACT The human body functions as a natural reactor for a vast network of chemical and biological reactions and physical interactions among small molecules, proteins, cells, and numerous other components. These reactions/interactions are essential for maintaining normal physiological functions.
Yuhao Cai, Chao Zhao
wiley   +1 more source

Dynamics and tendency of sick rate in children of urban areas with different quality of the atmospheric air

RUDN Journal of Medicine, 2016
In the article there are results of the comparative analysis of dynamics and tendencies of main diseases incidence in children constantly living in the city districts characterizing by different quality of the atmospheric air.
A A Dementyev, A A Lyapkalo, O E Konovalov, A M Tsurgan   +3 more
doaj  

NLSS3 Impairs SHM1 Autophagic Degradation to Regulate Leaf Morphology and Salt Tolerance in Rice

Advanced Science, EarlyView.
In rice, NLSS3 binds and shields SHM1 from autophagic degradation to maintain serine homeostasis. The A132P mutation in nlss3 disrupts this, triggering SHM1 loss, metabolic dysfunction, K+ imbalance, and impaired ROS scavenging, which collectively drive narrow leaves and salt sensitivity.
Xiong Liu, Yulu Yang, Zhiqi Hao, Jing Xu, Huibo Zhao, Qiang Zhang, Deyong Ren, Xia Li, Guojun Dong, Lan Shen, Li Zhu, Jiang Hu, Zhenyu Gao, Qing Li, Qian Qian, Guangheng Zhang   +15 more
wiley   +1 more source

CCT2 Promotes Prostate Cancer Progression Through EIF3F‐Dependent Stabilization of FASN

Advanced Science, EarlyView.
ABSTRACT Prostate cancer (PCa) is increasingly recognized to be driven by dysregulated lipid metabolism. Although fatty acid synthase (FASN) is highly expressed in PCa, the mechanisms governing FASN protein stability and its functional integration into oncogenic lipid metabolism remain poorly defined.
Shun Xu, Yifan Zhang, Haolin Li, Shengyu Zhao, Xiaoran Dai, Qili Xu, Mintian Fei, Chun Li, Zhihui Zou, Baojun Wang, Li Zhang, Hui Wang, Ligang Zhang, Chaozhao Liang   +13 more
wiley   +1 more source

Retrospective analysis of the incidence rate with the diseases of the genitourinary of the population of the Brest region / O. Kemezh, L. Pirogovskaya

, 2018
Медицинская экология: биомедицина, генетикаПриведены данные о заболеваемости населения Брестской обл. болезнями мочеполовой системы за период 2011–2016 гг.
Кемеж, О. Н., Пироговская, Л. Б.   +1 more
core  

A Foundation Model Based CT Biomarker for Non‐Invasive Prediction of Response to Neoadjuvant Immunochemotherapy in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
This study introduces a foundation model‐based biomarker for risk stratification of pathological response in non‐small cell lung cancer. A Vision Mamba super‐resolution model standardizes heterogeneous CT images. A multi‐task Swin Transformer then fine‐tunes a pre‐trained lung foundation model to jointly optimize tumor segmentation and response ...
Yanglan Xu, Shuchang Zhou, Qin Peng, Xiao Bao, Xiaodan Ye, Ahmet Görkem Er, Tong Tong, Mirabela Rusu, Yajia Gu, Mailin Chen, Jing Gong   +10 more
wiley   +1 more source

Report of one case with de novo mutation in TLK2 and literature review

BMC Pediatrics
TLK2 variants were identified as the cause for several neurodevelopmental disorders by impacting brain development. The incidence of mutation in TLK2 is low, which has common clinical features with other rare diseases.
Han-Yue Li, Chun-Ming Jiang, Ruo-Yan Liu, Chao-Chun Zou   +3 more
doaj   +1 more source

Adult Incidence in the Russian European Arctic with Developed Mining and Metallurgical Industry (en)

Российская Арктика, 2019
The purpose of the research. The research aims to assess the adult incidence within the mining complex in the Murmansk Region (the Russian Arctic). Materials and methods.
A. N. Nikanov, V.M. Dorofeev, L.V. Talykova, N.V. Sturlis, I.V. Gushin   +4 more
doaj   +1 more source