Results 71 to 80 of about 122,730 (293)

Emerging immunotherapeutic strategies targeting telomerases in genitourinary tumors

, 2018
Telomerase activity and telomere length are essential for the pathogenesis of several human diseases, including genitourinary tumors. Telomerase constitutes a complex system that includes human telomerase reverse transcriptase (hTERT), human telomerase ...
Tamberi, Stefano, Scarpelli, Marina, Montironi, Rodolfo, Battelli, Nicola, Santoni, Matteo, Piva, Francesco, Lopez-Beltran, Antonio, Carrozza, Francesco, Cheng, Liang   +8 more
core   +1 more source

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source

THE CHARACTERISTICS OF THE HEALTH STATE POPULATION IN CENTRAL SERBIA

Sanamed, 2016
The aim of this study is to analyze the health status of the population in Central Serbia, in order to identify priority health problems. As a source of data, authots use the reports about diseases, conditions and injuries services for the health care ...
Radovanovic Snezana, Kocic Sanja, Vasiljevic Dragan, Radevic Svetlana, Janicijevic Katarina, Mihailovic Natasa   +5 more
doaj   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

Advanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott, Georgeos Hardo, Ruizhe Li, Jack Bradley, Ashraf Zarkan, Somenath Bakshi   +5 more
wiley   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Dynamics of disability due to diseases of the genitourinary system in Ukraine and its regions

Urology, 2019
The dynamics of the primary recognized invalids due to diseases of the genitourinary system in general in Ukraine in two periods: 2008–2012 and 2013–2017 years are presented. The results were analyzed and compared with the indicators in five regions of the country, taking into account the areas of their composition. Official reporting data was used.
Saidakova, N.O., Dmytryshyn, S.P., Grodinskiy, V.I.   +2 more
openaire   +3 more sources

Prevalence of Congenital Malformations among Babies Delivered at a Tertiary Care Hospital

Journal of Nepal Medical Association, 2020
Introduction: Congenital malformations have emerged as a major cause of stillbirths and neonatal mortality. It is a common cause of morbidity and mortality not only in the newborn but also in childhood and beyond.
Sabina Shrestha, Anup Shrestha
doaj   +1 more source

Chronic inflammatory processes of the maternal genitourinary system, its role in cardiovascular diseases development in their children: Ukrainian and European experience of prevention as the key to the health of future generations

, 2023
Cardiovascular diseases (CVDs) remain the leading cause of morbidity in the world. The burden of CVDs continues to increase over the past decade in almost all countries of the world. The prevalence of CVDs in the world has almost doubled from 271 million
Myroshnychenko, Mykhailo, Olianych, Serhii, Kapustnyk, Nataliia, Pasiyeshvili, Nana, Bibichenko, Victoria   +4 more
core  

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

Advanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo, Chunru Xu, Shufan Fu, Qiang Cheng, Juan Li, Linkuo Shang, Gaojie Li, Yang Yang, Ying Wang, Yanqing Gong, Shengwei Xiong, Jian Fan, Changwei Yuan, Mei Zhang, Yifan Zuo, Elena Papaleo, Yue Shi, Yuan Liang, Xuesong Li, Hongzhao Li, Weimin Ci   +20 more
wiley   +1 more source

Emergency department 72-hour revisits among children with chronic diseases: a Saudi Arabian study

BMC Pediatrics, 2018
Background Emergency Department (ED) revisits have often been used as an indicator of medical care quality. This study aimed to quantify the frequency of ED revisits within 72 h of discharge and identify its factors among children with chronic diseases ...
Anwar E. Ahmed, Bashayr I. ALMuqbil, Manair N. Alrajhi, Hend R. Almazroa, Doaa A. AlBuraikan, Monirah A. Albaijan, Maliha Nasim, Majid A. Alsalamah, Donna K. McClish, Hamdan AL-Jahdali   +9 more
doaj   +1 more source