Results 61 to 70 of about 122,841 (259)

Characteristics of HLA and Cytokine Production in Patients with Diseases of the Genitourinary System

Health of Man
Immunogenetic diagnostics allows identifying individuals with a high degree of risk of developing certain diseases, and associative connections with the cytokine link of immunity to expand ideas about their immunogenesis to determine prognostic markers and its course. The objective: to evaluate the associative relationships between the HLA-phenotype of
Vozianov, Serhiy, Kolesnyk, Mykola, Driianska, Victoria, Shulyak, Oleksandr, Poroshina, Tetyana, Nurimanov, Kamil, Bondarenko, Yuri, Petryna, Olena, Savchenko, Viktoriya   +8 more
openaire   +4 more sources

Dynamics and tendency of sick rate in children of urban areas with different quality of the atmospheric air

RUDN Journal of Medicine, 2016
In the article there are results of the comparative analysis of dynamics and tendencies of main diseases incidence in children constantly living in the city districts characterizing by different quality of the atmospheric air.
A A Dementyev, A A Lyapkalo, O E Konovalov, A M Tsurgan   +3 more
doaj  

Cholesterol Laundry of Cell Membrane and Fatty Liver by Detergent Liposomes to Improve Anti‐Cancer Drug Responsiveness of Patient Liver Tissues

Advanced Science, EarlyView.
Cholesterol‐enriched plasma membranes in hepatocellular carcinoma impede drug penetration. Cholesterol (+)‐liposomes act as membrane‐specific detergents, extracting cholesterol and reducing barrier function without cytotoxicity. Following endocytosis, cholesterol transfers from endosomes to liposomes and is metabolized in the ER.
Chansik Kim, Joo Kyung Noh, Sewoom Baek, Seung Eun Yu, Jueun Kim, Seongyo Lee, Youngji Oh, Dai Hoon Han, Seyong Chung, Hak‐Joon Sung   +9 more
wiley   +1 more source

Single‐Cell and Spatial Transcriptomics Unveil Key Regulators Governing Cell Differentiation for Schistosoma japonicum Sexual Development

Advanced Science, EarlyView.
Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu, Xiaoxu Wang, Shun Li, Xuxin Li, Pengfei Du, Yameng Zheng, Lu Liu, Yanyan Zhang, Omri Wurtzel, Guofeng Cheng   +9 more
wiley   +1 more source

Immunoglobulin G4–Related Disease of the Genitourinary System

O&G Open
BACKGROUND: Immunoglobulin G4–related disease (IgG4-RD) is an immune-mediated disease that is often misdiagnosed given its rare incidence and misleading presentation. Prior case studies have described IgG4-RD involving the ovaries, uterus, and bladder. This article describes the first case of vaginal IgG4-RD.
Meryl G. Warshafsky, Margaret A. Flanigan, Sarah G. Bell, Sharon A. Kreuer, Erika M. Moore, Shannon K. Rush   +5 more
openaire   +1 more source

Profile and trend analysis of diseases of the genitourinary system in the Philippines

International Journal of Public Health Science (IJPHS)
<p>In the Philippines, kidney disease is acknowledged as a significant public health issue as it causes considerable suffering, negatively impacts health, and possibly death to people inflicted it, this is despite the available programs and efforts to combat these diseases.
Mangotara, Rosnia D., Balt, Arafat M., Demayo, Chin-Chin J., Sambawa, Nihaya G., Demayo, Cesar G.   +4 more
openaire   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Report of one case with de novo mutation in TLK2 and literature review

BMC Pediatrics
TLK2 variants were identified as the cause for several neurodevelopmental disorders by impacting brain development. The incidence of mutation in TLK2 is low, which has common clinical features with other rare diseases.
Han-Yue Li, Chun-Ming Jiang, Ruo-Yan Liu, Chao-Chun Zou   +3 more
doaj   +1 more source

Adult Incidence in the Russian European Arctic with Developed Mining and Metallurgical Industry (en)

Российская Арктика, 2019
The purpose of the research. The research aims to assess the adult incidence within the mining complex in the Murmansk Region (the Russian Arctic). Materials and methods.
A. N. Nikanov, V.M. Dorofeev, L.V. Talykova, N.V. Sturlis, I.V. Gushin   +4 more
doaj   +1 more source

Risk of Inflammatory Bowel Disease Following Hospital‐Treated Infections and Modulatory Role of Host Genetics to Support a Multi‐Hit Pathogenesis Model

Advanced Science, EarlyView.
Hospital‐treated infections are linked to increased risk of inflammatory bowel disease in a large prospective cohort. This risk differs by infection burden, time since infection, and host immune‐genetic susceptibility. The findings support a multi‐hit pathogenesis model in which severe infection and inherited susceptibility jointly shape inflammatory ...
Haiming Zhuang, Lintao Dan, Xin Xiang, Xixian Ruan, Shuai Yuan, Jialu Yao, Jiawei Geng, Jonas F. Ludvigsson, Tian Fu, Candida Abreu, Laurent Peyrin‐Biroulet, Xue Li, Yi Xiao, Fernando Magro, Xiaoyan Wang, Jing Sun, Jie Chen   +16 more
wiley   +1 more source