Results 61 to 70 of about 122,730 (293)

Nanocellulose Alleviates Intrahepatic Cholestasis of Pregnancy via Gut Microbiota‐Mediated Bile Acid Homeostasis

Advanced Science, EarlyView.
Nanocellulose, derived from microcrystalline cellulose (MCC) through sulfuric acid hydrolysis or mechanical grinding to produce CNC or CNF, was tested in a rat ICP model. Particularly, CNF improved gut microbiota composition, reduced secondary bile acid metabolism, and restored bile acid homeostasis through modulation of the gut–liver axis.
Muhua Yu, Hongjie Dai, Xiaocui Zhong, Qibin Li, Hui Yuan, Yang Yang, Daiyong Huang, Lei Zhang, Rui Ran, Tian He, Yuanzhi Huang, Silas Villas‐Boas, Sergey Tumanov, Richard D. Cannon, Boris Novakovic, Richard Saffery, Yuhao Zhang, Xiaojing Dong, Ting‐Li Han   +18 more
wiley   +1 more source

THE ROLE OF PROTOZOAL INFESTATIONS IN CHRONIC INFLAMMATION EXACERBATIONS IN PATIENTS WITH GENITOURINARY PATHOLOGY

, 2018
The aim: to study the prevalence of protozoal infestations in cases of acute inflammatory exacerbations in genitourinary clinic. Materials and methods. The method of polymerase chain reaction was used to examine 158 subjects with chronic ...
Mavrov, Gennadiy, Fedorych, Pavlo
core   +1 more source

PRC2.1 Coordinates Peri‐Nucleolar H3K27me3‐Enriched Heterochromatin Organization and NPM1 Pentamerization to Maintain Nucleolar Integrity

Advanced Science, EarlyView.
PRC2.1(PCL2)‐coordinated H3K27me3‐enriched PNH establishes a spatial scaffold crucial for nucleolar integrity. As a crucial coordinator, PCL2 links PRC2.1 to chromatin organization and NPM1 assembly. This network‐based model reveals how chromatin modifications and nucleolar components cooperatively maintain nucleolar architecture, revealing novel ...
Lina Zhu, Wenqin Wang, Shuyun Chen, Gangyi Zhu, Zhen Wu, Yue Gu, Jingwen Xiong, Xu Zhang, Heng Liu, Kyoichi Isono, Youming Zhang, Jingjing Cao, Xiangzhi Li   +12 more
wiley   +1 more source

Within the 60 years, based on the disease distribution, respiratory diseases ranked the highest, followed by circulatory diseases and brain diseases (Figure 2A).

, 2014
In terms of the diagnostic error rate, the 2000–9 group was the highest. Second was the 1970–9 group, and third was the 1990–9 group (Figure 2B). In terms of the diseases, the most misdiagnosed were in the circulatory system.
Haijia Feng (666488), Liqing Ma (666491), Minche Chen (666492), Wei Zhang (405), Qiunian Shi (666493), Suojiang Zhang (666494), Keqing Zhu (304790), Yinhan Xu (666489), Jian Chen (15340), Zhengrong Mao (666490)   +9 more
core   +1 more source

Androgen Receptor‐Induced Lactoferrin Accelerates Prostate Tumorigenesis Through Modulating Ferroptosis

Advanced Science, EarlyView.
This study demonstrates that transcription factor androgen receptor (AR) directly binds the LF promoter, driving lactoferrin overexpression to promote ferritin (FTH1/FTL) upregulation and inhibit p53‐ALOX12‐mediated ferroptosis in prostate cancer. Lactoferrin could be a new potential therapeutic target in prostate cancer.
Can Liu, Qiu Peng, Xiaoyue Zhang, Zhengshuo Li, Yangge Wu, Yuqing Wen, Run Zheng, Shuanglong Wu, Chenfei Zhou, Zhengyu Hu, Lanjun Shu, Xinyi Ma, Qiuyang Li, Ya Ma, Chunlin Ou, Ming Zhao, Songqing Fan, Lingyu Wei, Jian Ma   +18 more
wiley   +1 more source

Integration of Spatiotemporal Multi‐Omics in Peach Fruit Unravels a Metabolic Niche and the Genetic Basis of Trichome‐Mediated Stress Adaptation

Advanced Science, EarlyView.
This study constructed the first spatiotemporal multi‐omics map of peach fruit and discovered a key candidate gene that synergistically regulates trichome development and drought tolerance through the jasmonic acid signaling pathway, providing insights into the coupling mechanism between development and stress resistance.
Zhixin Liu, Ke Cao, Liping Guan, Aizhi Qin, Yong Li, Zihao Zhao, Yinpeng Zhang, Yaping Zhou, Lirong Wang, Xuwu Sun   +9 more
wiley   +1 more source

Genitourinary tract cancers: Frequency and demographic characteristics

, 2019
Context: As one of the most common cancers in clinical practice, genitourinary system tumors are reported to grow worldwide. Aims: We aimed to describe the frequency and demographic characteristics of such cancers' in Isfahan Province/Iran. Materials and
Mazdak, Hamid, Saboori, Masih, Tolou-Ghamari, Zahra, Sichani, Mehrdad Mohammadi   +3 more
core   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Exploring health needs and the double burden of disease in adults attending public health facilities in the Iraqi Kurdistan

Frontiers in Public Health
ObjectiveWe analyzed the health needs of the adult population accessing public health facilities in the Iraqi Kurdistan, a region facing both demographic and epidemiological transitions while undergoing post-crisis recovery.
Stefania Moramarco, Mariagrazia Cicala, Faiq B. Basa, Gorgees S. Akhshirsh, Antonia Bezenchek, Rafal S. L. Adhama, Bayar S. Azeez, Sivar A. Qadir, Shahla O. Salih, Luma H. H. Alhanabadi, Iuri Fanti, Berivan A. Tofiq, Daniele Di Giovanni, Leonardo Emberti Gialloreti, Paola Scarcella   +14 more
doaj   +1 more source

Impaired fertility and reproductive function in patients with complicated forms of inflammatory diseases of the genitourinary system [PDF]

Medical news of the North Caucasus, 2015
A comparative study of the effectiveness of complex therapy of patients with sexual dysfunction on the background of sexually transmitted infections was carried out. Patients were examined by PCR, PCR, Real Time, IFA, ureteroscopy and investigation of ejaculate. 102 patients were divided into two groups.
Askhakov M.S., Chebotaryov V.V., Chebotaryova N.V., Lajpanov I.M.   +3 more
openaire   +3 more sources