Results 181 to 190 of about 2,879,932 (270)

Machine Learning–Driven Screening of High‐Activity Antitumor Nanozymes Using an Ensemble Enzymatic Oracle System

Cancer Nexus, EarlyView.
ABSTRACT Nanozymes, by mimicking the catalytic sites of natural enzymes, have emerged as effective substitutes for traditional natural enzymes. However, the relationship between the physicochemical properties and activity of nanozymes is complex and nonlinear.
Guanmeng Zhang, Mutian Yang, Jie Zang, Xiaoli Li, Qinqiu Zhong, Yuxiang Hu, Yumeng Xie, Ludan Zhang, Yuping Qian, Jinna Ren, Yang Peng, Haitao Chen, Jiandong Gao, Ji Wu, Yuguang Wang   +14 more
wiley   +1 more source

Musculoskeletal diseases, infections and vaccines: state of the art, research perspectives and educational needs. [PDF]

Aging Clin Exp Res
Ecarnot F, Thiyagarajan JA, Barbagallo M, Barratt J, Constantinescu S, Elkayam O, Ferrucci L, Hiligsmann M, Kapetanovic M, Macchia F, Michel JP, Migliore A, Pilotto A, Sieber C, Strangfeld A, Veronese N, Vetrano DL, Maggi S, Rizzoli R.   +18 more
europepmc   +1 more source

First‐in‐Human Single and Multiple Ascending Dose Studies of Balinatunfib, a Small Molecule Inhibitor of TNFR1 Signaling in Healthy Participants

Clinical Pharmacology &Therapeutics, EarlyView.
Oral small molecule inhibitors of tumor necrosis factor alpha (TNFα) are emerging as attractive therapeutic agents for the treatment of various autoimmune diseases. Balinatunfib (SAR441566), a novel oral inhibitor of tumor necrosis factor receptor 1 (TNFR1) signaling, changes the configuration of the soluble TNFα (sTNFα) trimer and prevents its ...
Nassr Nassr, Faiza Rharbaoui, Dietmar Weitz, Johann Gassenhuber, Markus Rehberg, Markus Kohlmann, Fabienne Schumacher, Amel Lahmar, Andreas Kovar, Laurent Perrin, Frank‐Dietrich Wagner, Maria Wiekowski, Mai Anh Nguyen   +12 more
wiley   +1 more source

ESR1 Variants and Subcontinental Genomic Ancestry: Insights from the 1000 Genomes Project and Native American Populations

Clinical Pharmacology &Therapeutics, EarlyView.
The ESR1 gene is relevant in breast cancer treatments in the pharmacogenetics context. However, Native, African, and mixed populations are known to be underrepresented in genomic studies. This is particularly important given that the difference in variants' frequencies among different populations can lead to population‐specific clinical implications ...
Mariana M. Scudeler, Caíque Manóchio, Bruno Miwa, Guilherme Belfort‐Almeida, Lucas Faria‐Costa, Cesar Sanchez, Carlos Padilla, Omar Caceres, Eduardo Tarazona‐Santos, Heinner Guio, Timothy D. O'Connor, Fernanda Rodrigues‐Soares   +11 more
wiley   +1 more source

Hospitalization dynamics during COVID-19: Insights into disease trends and patient outcomes. [PDF]

PLoS One
Motiei M, Hassanzadeh Rad A, Badeli H, Bayat R.   +3 more
europepmc   +1 more source

Prevalence of Actionable Pharmacogenetic Genotype Frequencies, Cautionary Medication Use, and Polypharmacy in Community‐Dwelling Older Adults

Clinical Pharmacology &Therapeutics, EarlyView.
Older adults (65 years and over) frequently manage complex medication regimens and are vulnerable to adverse drug reactions and treatment inefficacies, some of which could be preventable with pharmacogenetics (PGx)‐guided prescribing. This study examined the prevalence of actionable PGx genotypes (i.e., those linked to a guideline that recommends a ...
Chad A. Bousman, Ankita Narang, Ziad Al Bkhetan, Robyn L. Woods, Suzanne G. Orchard, Alice J. Owen, Michelle A. Fravel, Julia Gilmartin‐Thomas, Joanne Ryan, Peter D. Fransquet, Rory Wolfe, Chenglong Yu, John J. McNeil, Paul Lacaze, Michael E. Ernst   +14 more
wiley   +1 more source

Editorial: The endocrine role of the musculoskeletal system. [PDF]

Front Endocrinol (Lausanne)
Zhu S, Storlino G, Kumar S.
europepmc   +1 more source

Annual Banned‐Substance Review 17th Edition—Analytical Approaches in Human Sports Drug Testing 2023/2024

Drug Testing and Analysis, EarlyView.
Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario  Thevis, Tiia  Kuuranne, Hans  Geyer   +2 more
wiley   +1 more source

Extracellular vesicles: their challenges and benefits as potential biomarkers for musculoskeletal disorders. [PDF]

J Int Med Res
Sung SE, Seo MS, Park WT, Lim YJ, Park S, Lee GW.   +5 more
europepmc   +1 more source

Comparison of incidence, prevalence and death of aortic stenosis and aortic insufficiency in a nationwide Korean study

ESC Heart Failure, EarlyView.
Abstract Aims Few studies have examined the incidence, prevalence, survival rate and death risk for non‐rheumatic and rheumatic aortic stenosis (AS; RAS), aortic insufficiency (AR; RAR) and aortic stenosis with insufficiency (ASAR; RASAR). This study aims to identify the epidemiology of AS, AR, ASAR, RAS, RAR and RASAR.
Shin Yi Jang, Sung‐Ji Park, Eun Kyoung Kim, Seung Woo Park   +3 more
wiley   +1 more source