Results 181 to 190 of about 308,099 (338)

The Effect of Drug Vintage on Survival: Micro Evidence from Puerto Rico's Medicaid Program [PDF]

Using micro data on virtually all of the drugs and diseases of over 500,000 people enrolled in Puerto Rico's Medicaid program, we examine the impact of the vintage (original FDA approval year) of drugs used to treat a patient on the patient's 3-year ...
Frank R. Lichtenberg
core  

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4‐α5β1 Axis

Advanced Science, EarlyView.
Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng, Yunsheng Jiang, Zhiyu Chen, Kaiquan Chen, Na Cao, Yang Huang, Zhengxue Quan, Cheng Chen   +7 more
wiley   +1 more source

Musculoskeletal system involvement in adult Wilson’s disease: a case report

, 2016
Şule Şahin Onat
openalex   +1 more source

Tumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A‐Dependent hnRNPA2B1/COX‐2 Axis

Advanced Science, EarlyView.
Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li, Zehao Guo, Yutong Zou, Jiongfeng Zhang, Jixiang Shi, Xihong Fu, Jian Tu, Hao Yao, Xuanxuan Lu, Lili Wen, Xianbiao Xie   +10 more
wiley   +1 more source

Apelin: A Promising Therapeutic Target for Degenerative Diseases of the Musculoskeletal System [PDF]

Jinkun Xu, Hengzhen Li, Jianfeng Sun, Gaoming Liu, Yuming Yao, Dongliang Yuan, Wenfeng Xiao, Yusheng Li   +7 more
openalex   +1 more source

Spatial Transcriptomics of TMJ Reveals a Remodeling Fibroblast‐Immune Microenvironment Driving Arthritis Pain

Advanced Science, EarlyView.
Spatial transcriptomics reveals a remodeled fibroblast‐immune microenvironment in the temporomandibular joint (TMJ) during arthritis. By combining seqFISH with genetic mouse models, this study uncovers TMJ spatial cell atalas, macrophage‐fibroblast crosstalk, and cytokine signaling pathways driving TMJ inflammation and pain.
Ziying Lin, Supawadee Jariyasakulroj, Yang Shu, Jingyi Chen, Qing Chang, Pao‐Fen Ko, Yuyueyang Qiu, Feixiang Chen, David Ahn, Zhen Zhao, Jian‐Fu Chen   +10 more
wiley   +1 more source

Understanding the Twentieth Century Decline in Chronic Conditions Among Older Men [PDF]

I use a sample of Union Army veterans to trace the impact of a high infant mortality rate in area of enlistment, such infectious disease as acute respiratory infections, measles, typhoid fever, tuberculosis, rheumatic fever, diarrhea, and malaria while ...
Dora L. Costa
core  

Gut Microbiota‐Non‐Coding RNA Axis in Immune Modulation and Disease: From Mechanisms to Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Immune homeostasis is indispensable for preserving organismal integrity, orchestrated through complex molecular networks encompassing immune cell dynamics, microbial cues, and epigenetic regulation. Among these, the gut microbiota‐non‐coding RNA (ncRNA) axis has recently garnered substantial attention as a multifaceted modulator of host ...
Bonan Chen, Guoming Chen, Xieyuan Leng, Qianfan Li, Wenhao Wu, Wenqiu Wu, Zixuan Liu, Zilan Zhong, Xiaohong Zheng, Wei Kang, Fazheng Ren, Yigan Zhang, Juan Chen   +12 more
wiley   +1 more source

Imaging of Systemic Rheumatoid Diseases Involving the Musculoskeletal System (CME-Reply Form) [PDF]

, 2004
F. Kainberger
openalex   +1 more source

The Musculoskeletal Manifestation Among Patients with Different Thyroid Diseases and The Role of Thyroid Hormones on Musculoskeletal System

, 2023
Sara Haraken, Sara Harakan, Abeer Shahba, Yasser Mostafa Hafez, Haidy Ali Mohamed Ali, A Alahmar, S Dutta, P Sengupta, V Apuzzi, A Vitelli, Calderaro Sr, F Sr, O Fattoruso, V Bassi, B Ataallah, M Abdulrahman, G Kulina, L Bazzichi, A Rossi, T Giuliano, F De Feo, C Giacomelli, A Consensi, L Churilov, P Sobolevskaia, Y Stroev, G Clunie, N Wilkinson, E Nikiphorou, D Jadon, S Cohen, S Strassels, L Foster, J Marvel, K Williams, M Crooks, M D'agostino, W Schmidt, M De Stefano, R Ambrosio, T Porcelli, G Orlandino, D Salvatore, C Luongo, A Delitala, A Scuteri, C Doria, J Finsterer, W Lscher, J Wanschitz, S Quasthoff, W Grisold, J Huffer, M Hussein, F Alyahya, H Barradah, A Almuhanaa, B Mohammed, A Alanazi, R Isida, V Bariatinsky, G Kern, G Dereudre, X Demondion, C Chantelot, C Johnstone, C Hendry, A Farley, E Mclafferty, H Kehlet, P Kertzman, M Lenza, A Pedrinelli, B Ejnisman, R Lu, H Wang, T Hong, H Gao, F Luskin, K Newell, M Griffith, M Holmes, S Telles, E Dinucci, H Moutsopoulos, E Zampeli, R Mullur, Y Liu, G Brent, P Rush, A Shore, N Shah, T Ursani, N Shah, H Raza, K Shahzad, W Mati, C Tagoe, A Zezon, S Khattri   +99 more
openalex   +1 more source