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Infectious Diseases of the Nervous System [PDF]

Atlas of Clinical Neurology, 2011
The curriculum for child neurology trainees should include information regarding the many infectious and post-infectious disorders that affect the developing nervous system. This article provides recommendations regarding the nature of the educational content and suggestions how this content can be provided to trainees.
europepmc   +3 more sources

Lost in translational biology: Understanding sex differences to inform studies of diseases of the nervous system. [PDF]

Brain Res, 2019
Pearse RV, Young-Pearse TL.
europepmc   +3 more sources

Chronic stress accelerates glioblastoma progression via DRD2/ERK/β-catenin axis and Dopamine/ERK/TH positive feedback loop

Journal of Experimental & Clinical Cancer Research, 2023
Background After diagnosis, glioblastoma (GBM) patients undertake tremendous psychological problems such as anxiety and depression, which may contribute to GBM progression.
Yan Wang, Xiang Wang, Kai Wang, Ji Qi, Yu Zhang, Xu Wang, Long Zhang, Yi Zhou, Linbo Gu, Rutong Yu, Xiuping Zhou   +10 more
doaj   +1 more source

RETRACTED ARTICLE: GRP78 determines glioblastoma sensitivity to UBA1 inhibition-induced UPR signaling and cell death

Cell Death and Disease, 2021
Glioblastoma multiforme (GBM) is an extremely aggressive brain tumor for which new therapeutic approaches are urgently required. Unfolded protein response (UPR) plays an important role in the progression of GBM and is a promising target for developing ...
Guanzheng Liu, Jiefeng Yu, Runqiu Wu, Lin Shi, Xu Zhang, Wanhong Zhang, Xiaomin Zhong, Yifeng Wang, Huan Li, Yang Shen, Changyong Wu, Rutong Yu, Mingshan Niu, Xuejiao Liu   +13 more
doaj   +1 more source

BYSL contributes to tumor growth by cooperating with the mTORC2 complex in gliomas

Cancer Biology & Medicine, 2021
Objective: BYSL, which encodes the Bystin protein in humans, is upregulated in reactive astrocytes following brain damage and/or inflammation. We aimed to determine the role and mechanism of BYSL in glioma cell growth and survival.
Shangfeng Gao, Zhuang Sha, Junbo Zhou, Yihao Wu, Yunnong Song, Cheng Li, Xuejiao Liu, Tong Zhang, Rutong Yu   +8 more
doaj   +1 more source

Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseases

Fluids and Barriers of the CNS, 2021
Background Several central nervous system diseases are associated with disturbed cerebrospinal fluid (CSF) flow patterns and have typically been characterized in vivo by phase-contrast magnetic resonance imaging (MRI). This technique is, however, limited
P. Eide, L. Valnes, E. Lindstrøm, K. Mardal, G. Ringstad   +4 more
semanticscholar   +1 more source

Application of New Radiosensitizer Based on Nano-Biotechnology in the Treatment of Glioma

Frontiers in Oncology, 2021
Glioma is the most common intracranial malignant tumor, and its specific pathogenesis has been unclear, which has always been an unresolved clinical problem due to the limited therapeutic window of glioma. As we all know, surgical resection, chemotherapy,
Yandong Xie, Yandong Xie, Yandong Xie, Yuhan Han, Yuhan Han, Yuhan Han, Xuefeng Zhang, Hongwei Ma, Linfeng Li, Rutong Yu, Rutong Yu, Hongmei Liu, Hongmei Liu   +12 more
doaj   +1 more source

MELK Inhibition Effectively Suppresses Growth of Glioblastoma and Cancer Stem-Like Cells by Blocking AKT and FOXM1 Pathways

Frontiers in Oncology, 2021
Glioblastoma multiforme (GBM) is a devastating disease yet no effective drug treatment has been established to date. Glioblastoma stem-like cells (GSCs) are insensitive to treatment and may be one of the reasons for the relapse of GBM. Maternal embryonic
Xu Zhang, Xu Zhang, Xu Zhang, Jie Wang, Jie Wang, Jie Wang, Yifeng Wang, Yifeng Wang, Guanzheng Liu, Huan Li, Jiefeng Yu, Runqiu Wu, Jun Liang, Rutong Yu, Rutong Yu, Xuejiao Liu, Xuejiao Liu   +16 more
doaj   +1 more source

Squalenoyl siRNA PMP22 nanoparticles are effective in treating mouse models of Charcot-Marie-Tooth disease type 1 A

Communications Biology, 2021
Boutary et al. describe siRNA based therapy conjugated with squalene nanoparticles as an efficient approach to normalize PMP22 protein levels, restore locomotor activity, electrophysiological parameters and function of myelin sheath in CMT1A mouse models.
Suzan Boutary, Marie Caillaud, Mévidette El Madani, Jean-Michel Vallat, Julien Loisel-Duwattez, Alice Rouyer, Laurence Richard, Céline Gracia, Giorgia Urbinati, Didier Desmaële, Andoni Echaniz-Laguna, David Adams, Patrick Couvreur, Michael Schumacher, Charbel Massaad, Liliane Massaad-Massade   +15 more
doaj   +1 more source

Propionate exerts neuroprotective and neuroregenerative effects in the peripheral nervous system

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance In inflammatory diseases of the peripheral nervous system, oxidative stress and neurodegeneration are the main factors resulting in long-term clinical disability.
T. Grüter, Nuwin Mohamad, Niklas Rilke, A. Blusch, M. Sgodzai, S. Demir, X. Pedreiturria, Katharina Lemhoefer, B. Gisevius, A. Haghikia, A. Fisse, J. Motte, R. Gold, K. Pitarokoili   +13 more
semanticscholar   +1 more source