Results 21 to 30 of about 1,619,548 (347)

NOD1/RIP2 signalling enhances the microglia-driven inflammatory response and undergoes crosstalk with inflammatory cytokines to exacerbate brain damage following intracerebral haemorrhage in mice

Journal of Neuroinflammation, 2020
Background Secondary brain damage caused by the innate immune response and subsequent proinflammatory factor production is a major factor contributing to the high mortality of intracerebral haemorrhage (ICH).
Miao Wang, Xinchun Ye, Jinxia Hu, Qiuchen Zhao, Bingchen Lv, Weijing Ma, Weiwei Wang, Hanhan Yin, Qi Hao, Chao Zhou, Tao Zhang, Weifeng Wu, Yan Wang, Mingyue Zhou, Cong-hui Zhang, Guiyun Cui   +15 more
doaj   +1 more source

Enzyme replacement therapies: What is the best option? [PDF]

, 2018
Despite many beneficial outcomes of the conventional enzyme replacement therapy (ERT), several limitations such as the high-cost of the treatment and various inadvertent side effects including the occurrence of an immunological response against the ...
Barar, Jaleh, Khiavi, Mostafa Akbarzadeh, Mousavi, Rahimeh, Rafi, Mohammad, Safary, Azam   +4 more
core   +2 more sources

Overexpression of RASD1 inhibits glioma cell migration/invasion and inactivates the AKT/mTOR signaling pathway

Scientific Reports, 2017
The RAS signaling pathway is hyperactive in malignant glioma due to overexpression and/or increased activity. A previous study identified that RASD1, a member of the RAS superfamily of small G-proteins, is a significantly dysregulated gene in ...
Shangfeng Gao, Lei Jin, Guangping Liu, Peng Wang, Zonghan Sun, Yujia Cao, Hengliang Shi, Xuejiao Liu, Qiong Shi, Xiuping Zhou, Rutong Yu   +10 more
doaj   +1 more source

Analysis of enteric nervous system and intestinal epithelial barrier to predict complications in Hirschsprung’s disease

Scientific Reports, 2020
In Hirschsprung’s disease (HSCR), postoperative course remains unpredictable. Our aim was to define predictive factors of the main postoperative complications: obstructive symptoms (OS) and Hirschsprung-associated enterocolitis (HAEC).
Anne Dariel, Lucie Grynberg, Marie Auger, Chloé Lefèvre, Tony Durand, Philippe Aubert, Catherine Le Berre-Scoul, Aurélien Venara, Etienne Suply, Marc-David Leclair, Philine de Vries, Guillaume Levard, Benoit Parmentier, Guillaume Podevin, Françoise Schmitt, Véronique Couvrat, Sabine Irtan, Erik Hervieux, Thierry Villemagne, Hubert Lardy, Carmen Capito, Cécile Muller, Sabine Sarnacki, Jean-François Mosnier, Louise Galmiche, Pascal Derkinderen, Hélène Boudin, Charlène Brochard, Michel Neunlist   +28 more
doaj   +1 more source

Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms

Scientific Reports, 2021
Gastrointestinal symptoms are frequent in acute adrenal insufficiency. Although digestive symptoms can significantly reduce quality of life, they are rarely described in patients with treated chronic adrenal insufficiency (CAI).
L. Quénéhervé, D. Drui, J. Blin, M. Péré, E. Coron, G. Barbara, M. R. Barbaro, B. Cariou, M. Neunlist, D. Masson, K. Bach-Ngohou   +10 more
doaj   +1 more source

Indukált pluripotens őssejtek szerepe a neurológiai betegségek modellezésében [PDF]

, 2015
The longitudinal follow-up of the development and course of central nervous system related diseases on a molecular level was unsolved for decades. Direct examination of the pathological state on organ or tissue levels was feasible in the late stage of ...
Balogh, Zoltán, Molnár, Mária Judit, Réthelyi, János   +2 more
core   +1 more source

Bacteria Wear ICG Clothes for Rapid Detection of Intracranial Infection in Patients After Neurosurgery and Photothermal Antibacterial Therapy Against Streptococcus Mutans

Frontiers in Bioengineering and Biotechnology, 2022
Bacterial infection is one of the most serious physiological conditions threatening human health. There is an increasing demand for more effective bacterial diagnosis and treatment through non-invasive approaches.
Long Zhang, Long Zhang, Long Zhang, Deyun Zhang, Hai Tang, Yufu Zhu, Yufu Zhu, Hongmei Liu, Hongmei Liu, Hongmei Liu, Rutong Yu, Rutong Yu   +11 more
doaj   +1 more source

Differential in vitro infection of neural cells by astroviruses [PDF]

, 2019
Encephalitis remains a diagnostic conundrum in humans as over 50% of cases are managed without the identification of an etiology. Astroviruses have been detected from the central nervous system of mammals in association with disease, suggesting that this
Janowski, Andrew B, Klein, Robyn S, Wang, David   +2 more
core   +2 more sources

Targeted up-regulation of Drp1 in dorsal horn attenuates neuropathic pain hypersensitivity by increasing mitochondrial fission

Redox Biology, 2022
Mitochondria play an essential role in pathophysiology of both inflammatory and neuropathic pain (NP), but the mechanisms are not yet clear. Dynamin-related protein 1 (Drp1) is broadly expressed in the central nervous system and plays a role in the ...
Kun-Long Zhang, Shu-Jiao Li, Xue-Yin Pu, Fei-Fei Wu, Hui Liu, Rui-Qing Wang, Bo-Zhi Liu, Ze Li, Kai-Feng Li, Nian-Song Qian, Yan-Ling Yang, Hua Yuan, Ya-Yun Wang   +12 more
doaj   +1 more source

Design and construction of a distributed sensor NET for biotelemetric monitoring of brain energetic metabolism using microsensors and biosensors [PDF]

, 2010
Neurochemical pathways involved in brain physiology or disease pathogenesis are mostly unknown either in physiological conditions or in neurodegenerative diseases.
Bazzu, Gianfranco, Calia, Giammario, Migheli, Rossana, Puggioni, Giulia, Rocchitta, Gaia Giovanna Maria, Serra, Pier Andrea   +5 more
core   +2 more sources