Results 111 to 120 of about 1,542,715 (367)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Recurrent high‐grade gliomas have a poor prognosis and limited therapeutic options. This study aimed to evaluate the safety and efficacy of SYHA1813, a dual inhibitor of VEGFR and CSF1R, in patients with recurrent high‐grade gliomas.
Zhuang Kang +16 more
wiley +1 more source
Extracellular proteases and their inhibitors ingenetic diseases of the central nervous system [PDF]
, 2017 Cumulative evidence has shown that a delicate balance between serine proteases and their inhibitors is crucial for normal functioning of several biological pathways.
Colleaux, Laurence +4 more
core
Conduction Block in the Peripheral Nervous System in Experimental Allergic Encephalomyelitis [PDF]
, 1982 Experimental Allergic Encephalomyelitis (EAE) has been widely studied as a model of multiple sclerosis, a central nervous system (CNS) disease of unknown aetiology.
Pender, M. P., Sears, T. A.
core +1 more source
NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao +10 more
wiley +1 more source
Editorial: The brain barriers in diseases of the nervous system. [PDF]
Front Cell Neurosci, 2023 Joukal M, Vulchanova L, Dubový P.
europepmc +1 more source
Vorinostat in the acute neuroinflammatory form of X‐linked adrenoleukodystrophy
Annals of Clinical and Translational Neurology, 2020 Objective To identify a pharmacological compound targeting macrophages, the most affected immune cells in inflammatory X‐linked adrenoleukodystrophy (cerebral X‐ALD) caused by ABCD1 mutations and involved in the success of hematopoietic stem cell ...
Bettina Zierfuss +17 more
doaj +1 more source
The effect of various drugs on experimentally induced ulcers in immobilized rats [PDF]
Experiments related to the importance of functional disorders in the central nervous system in connection with stomach diseases were performed on Wistar rats.
Schramm, H.
core +1 more source
Chronic Pain in Parkinson’s Disease: Prevalence, Sex Differences, Regional Anatomy and Comorbidities
Annals of Clinical and Translational Neurology, EarlyView.Chronic pain affected 66.2% of 10,631 individuals with Parkinson's disease, with higher prevalence and severity in females. Pain most often involved the buttocks, lower back, neck, and knees, and was linked to depression, sleep disorders, and osteoarthritis.
Natalia S. Ogonowski +13 more
wiley +1 more source
Editorial: Non-coding RNAs in diseases of the nervous system. [PDF]
Front Cell Neurosci, 2023 Reschke CR, Chowdhury EH, Lee AYW.
europepmc +1 more source