Results 11 to 20 of about 1,542,715 (367)

Propionate exerts neuroprotective and neuroregenerative effects in the peripheral nervous system

Proceedings of the National Academy of Sciences of the United States of America, 2023
Significance In inflammatory diseases of the peripheral nervous system, oxidative stress and neurodegeneration are the main factors resulting in long-term clinical disability.
T. Grüter, Nuwin Mohamad, Niklas Rilke, A. Blusch, M. Sgodzai, S. Demir, X. Pedreiturria, Katharina Lemhoefer, B. Gisevius, A. Haghikia, A. Fisse, J. Motte, R. Gold, K. Pitarokoili   +13 more
semanticscholar   +1 more source

MELK Inhibition Effectively Suppresses Growth of Glioblastoma and Cancer Stem-Like Cells by Blocking AKT and FOXM1 Pathways

Frontiers in Oncology, 2021
Glioblastoma multiforme (GBM) is a devastating disease yet no effective drug treatment has been established to date. Glioblastoma stem-like cells (GSCs) are insensitive to treatment and may be one of the reasons for the relapse of GBM. Maternal embryonic
Xu Zhang, Xu Zhang, Xu Zhang, Jie Wang, Jie Wang, Jie Wang, Yifeng Wang, Yifeng Wang, Guanzheng Liu, Huan Li, Jiefeng Yu, Runqiu Wu, Jun Liang, Rutong Yu, Rutong Yu, Xuejiao Liu, Xuejiao Liu   +16 more
doaj   +1 more source

Squalenoyl siRNA PMP22 nanoparticles are effective in treating mouse models of Charcot-Marie-Tooth disease type 1 A

Communications Biology, 2021
Boutary et al. describe siRNA based therapy conjugated with squalene nanoparticles as an efficient approach to normalize PMP22 protein levels, restore locomotor activity, electrophysiological parameters and function of myelin sheath in CMT1A mouse models.
Suzan Boutary, Marie Caillaud, Mévidette El Madani, Jean-Michel Vallat, Julien Loisel-Duwattez, Alice Rouyer, Laurence Richard, Céline Gracia, Giorgia Urbinati, Didier Desmaële, Andoni Echaniz-Laguna, David Adams, Patrick Couvreur, Michael Schumacher, Charbel Massaad, Liliane Massaad-Massade   +15 more
doaj   +1 more source

Research progress in molecular pathology markers in medulloblastoma

Exploration of Targeted Anti-tumor Therapy, 2023
Medulloblastoma (MB) is the commonest primary malignant brain cancer. The current treatment of MB is usually surgical resection combined with radiotherapy or chemotherapy.
Zixuan Zhou, Bingxin Zhu, Qingming Meng, Tong Zhang, Yihao Wu, Rutong Yu, Shangfeng Gao   +6 more
doaj   +1 more source

Neurotoxicity [PDF]

, 2014
Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust, Creeley, Feldman, Grandjean, Herken, Panzica, Parent, Pessah, Rice, Román, Spencer, Spencer, Tu, Vinken, Yasui, Zawia   +15 more
core   +2 more sources

Reversible inhibitor of CRM1 sensitizes glioblastoma cells to radiation by blocking the NF-κB signaling pathway

Cancer Cell International, 2020
Background Activation of nuclear factor-kappa B (NF-κΒ) through DNA damage is one of the causes of tumor cell resistance to radiotherapy. Chromosome region 1 (CRM1) regulates tumor cell proliferation, drug resistance, and radiation resistance by ...
Xuejiao Liu, Yiming Tu, Yifeng Wang, Di Zhou, Yulong Chong, Lin Shi, Guanzheng Liu, Xu Zhang, Sijin Wu, Huan Li, Shangfeng Gao, Mingshan Niu, Rutong Yu   +12 more
doaj   +1 more source

Construction and validation of a risk model based on the key SNARE proteins to predict the prognosis and immune microenvironment of gliomas

Frontiers in Molecular Neuroscience, 2023
BackgroundSynaptic transmission between neurons and glioma cells can promote glioma progression. The soluble N-ethylmaleimide-sensitive fusion factor attachment protein receptors (SNARE) play a key role in synaptic functions.
Luxin Yin, Luxin Yin, Yiqiang Xu, Yiqiang Xu, Jiale Yin, Hai Cheng, Weihan Xiao, Yue Wu, Yue Wu, Daofei Ji, Daofei Ji, Shangfeng Gao, Shangfeng Gao   +12 more
doaj   +1 more source

Facilitatory actions of guanidine on synaptic transmission in mammalian brain slices [PDF]

, 1979
Guanidine administration may be beneficial in the treatment of amyotrophic lateral sclerosis and related diseases; however, the actions of guanidine on the mammalian central nervous system have not been investigated.
Galvan, Martin, Grafe, Peter, Ten Bruggencate, Gerrit   +2 more
core   +1 more source

COVID‐19 and the peripheral nervous system. A 2‐year review from the pandemic to the vaccine era

Journal of the peripheral nervous system, 2022
Increasing literature has linked COVID‐19 to peripheral nervous system (PNS) diseases. In addition, as we move from the pandemic to the vaccination era, literature interest is shifting towards the potential association between COVID‐19 vaccines and PNS ...
Arens Taga, G. Lauria
semanticscholar   +1 more source

UBA1 inhibition contributes radiosensitization of glioblastoma cells via blocking DNA damage repair

Frontiers in Pharmacology, 2023
Glioblastoma multiforme (GBM) is a brain tumor with high mortality and recurrence rate. Radiotherapy and chemotherapy after surgery are the main treatment options available for GBM. However, patients with glioblastoma have a grave prognosis.
Changyong Wu, Changyong Wu, Yang Shen, Yang Shen, Lin Shi, Lin Shi, Lin Shi, Junhao Zhang, Tongxuan Guo, Lingni Zhou, Wanzhou Wang, Xu Zhang, Xu Zhang, Rutong Yu, Rutong Yu, Xuejiao Liu, Xuejiao Liu   +16 more
doaj   +1 more source