Results 21 to 30 of about 1,542,715 (367)

The Brain-Gut-Microbiome Axis. [PDF]

, 2018
Preclinical and clinical studies have shown bidirectional interactions within the brain-gut-microbiome axis. Gut microbes communicate to the central nervous system through at least 3 parallel and interacting channels involving nervous, endocrine, and ...
Kalani, Amir, Martin, Clair R, Mayer, Emeran A, Osadchiy, Vadim   +3 more
core   +2 more sources

Differential in vitro infection of neural cells by astroviruses [PDF]

, 2019
Encephalitis remains a diagnostic conundrum in humans as over 50% of cases are managed without the identification of an etiology. Astroviruses have been detected from the central nervous system of mammals in association with disease, suggesting that this
Janowski, Andrew B, Klein, Robyn S, Wang, David   +2 more
core   +2 more sources

Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs [PDF]

, 2020
In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination and/or stimulate myelin repair by
Chen, Xiaohong, Faller, Douglas V., Glavas, Ioannis P., Harpp, David N., Kanara, Iphigenia, Kodukula, Krishna, Mavrakis, Anastasios N., Moos, Walter H., Pernokas, Julie, Pernokas, Mark, Pinkert, Carl A., Powers, Whitney R., Sampani, Konstantina, Steliou, Kosta, Vavvas, Demetrios G., Zamboni, Robert J.   +15 more
core   +1 more source

Non-coding RNAs in the regulation of blood–brain barrier functions in central nervous system disorders

Fluids and Barriers of the CNS, 2022
The blood–brain barrier (BBB) is an essential component of the neurovascular unit that controls the exchanges of various biological substances between the blood and the brain.
Ping Sun, M. Hamblin, K. Yin
semanticscholar   +1 more source

The spleen: a hub connecting nervous and immune systems in cardiovascular and metabolic diseases [PDF]

, 2017
Metabolic disorders have been identified as major health problems affecting a large portion of the world population. In addition, obesity and insulin resistance are principal risk factors for the development of cardiovascular diseases.
Carnevale, Daniela, Lembo, Giuseppe, Lori, Andrea, Perrotta, Marialuisa   +3 more
core   +2 more sources

Glial aging and its impact on central nervous system myelin regeneration

Annals of the New York Academy of Sciences, 2022
Aging is a major risk factor for several neurodegenerative diseases and is associated with cognitive decline. In addition to affecting neuronal function, the aging process significantly affects the functional phenotype of the glial cell compartment ...
Khalil S. Rawji, Björn Neumann, R. Franklin   +2 more
semanticscholar   +1 more source

The Many Hats of Sonic Hedgehog Signaling in Nervous System Development and Disease. [PDF]

, 2016
Sonic hedgehog (Shh) signaling occurs concurrently with the many processes that constitute nervous system development. Although Shh is mostly known for its proliferative and morphogenic action through its effects on neural stem cells and progenitors, it ...
Belgacem, Yesser H, Borodinsky, Laura N, Hamilton, Andrew M, Shim, Sangwoo, Spencer, Kira A   +4 more
core   +2 more sources

Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2–expressing Treg cells

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Regulatory T (Treg) cells have been highlighted for their central function in limiting the severity of autoimmune diseases such as multiple sclerosis (MS).
Emilie Ronin, Charlotte Pouchy, M. Khosravi, M. Hilaire, Sylvie Grégoire, A. Casrouge, S. Kassem, David Sleurs, G. Martin, Noémie Chanson, Yannis Lombardi, Guilhem Lalle, H. Wajant, C. Auffray, B. Lucas, G. Marodon, Y. Grinberg-Bleyer, B. Salomon   +17 more
semanticscholar   +1 more source

Value of determining the cerebrospinal fluid protein markers of amyloidosis and neurodegeneration in the diagnosis of vascular and neurodegenerative cognitive impairments

Неврология, нейропсихиатрия, психосоматика, 2013
The article presents data on different forms of moderate cognitive impairments (MCI) and the specific features of their transformation to dementia. Cerebrospinal fluid (CSF) was investigated in 60 patients with the amnestic and neurodynamic types of MCI,
Vladimir Yuryevich Lobzin, A Yu Emelin, M M Odinak, L A Alekseeva, N E Monakhova   +4 more
doaj   +1 more source

NOD1/RIP2 signalling enhances the microglia-driven inflammatory response and undergoes crosstalk with inflammatory cytokines to exacerbate brain damage following intracerebral haemorrhage in mice

Journal of Neuroinflammation, 2020
Background Secondary brain damage caused by the innate immune response and subsequent proinflammatory factor production is a major factor contributing to the high mortality of intracerebral haemorrhage (ICH).
Miao Wang, Xinchun Ye, Jinxia Hu, Qiuchen Zhao, Bingchen Lv, Weijing Ma, Weiwei Wang, Hanhan Yin, Qi Hao, Chao Zhou, Tao Zhang, Weifeng Wu, Yan Wang, Mingyue Zhou, Cong-hui Zhang, Guiyun Cui   +15 more
doaj   +1 more source