Results 21 to 30 of about 1,261,678 (381)

Tissue-restricted control of established central nervous system autoimmunity by TNF receptor 2–expressing Treg cells

Proceedings of the National Academy of Sciences of the United States of America, 2021
Significance Regulatory T (Treg) cells have been highlighted for their central function in limiting the severity of autoimmune diseases such as multiple sclerosis (MS).
Emilie Ronin, Charlotte Pouchy, M. Khosravi, M. Hilaire, Sylvie Grégoire, A. Casrouge, S. Kassem, David Sleurs, G. Martin, Noémie Chanson, Yannis Lombardi, Guilhem Lalle, H. Wajant, C. Auffray, B. Lucas, G. Marodon, Y. Grinberg-Bleyer, B. Salomon   +17 more
semanticscholar   +1 more source

UBA1 inhibition contributes radiosensitization of glioblastoma cells via blocking DNA damage repair

Frontiers in Pharmacology, 2023
Glioblastoma multiforme (GBM) is a brain tumor with high mortality and recurrence rate. Radiotherapy and chemotherapy after surgery are the main treatment options available for GBM. However, patients with glioblastoma have a grave prognosis.
Changyong Wu, Changyong Wu, Yang Shen, Yang Shen, Lin Shi, Lin Shi, Lin Shi, Junhao Zhang, Tongxuan Guo, Lingni Zhou, Wanzhou Wang, Xu Zhang, Xu Zhang, Rutong Yu, Rutong Yu, Xuejiao Liu, Xuejiao Liu   +16 more
doaj   +1 more source

Quadrivalent HPV vaccination and risk of multiple sclerosis and other demyelinating diseases of the central nervous system.

Journal of the American Medical Association (JAMA), 2015
IMPORTANCE Case reports have suggested a link between human papillomavirus (HPV) vaccination and development of multiple sclerosis and other demyelinating diseases.
N. Scheller, H. Svanström, B. Pasternak, L. Arnheim‐Dahlström, K. Sundström, K. Fink, A. Hviid   +6 more
semanticscholar   +1 more source

The Many Hats of Sonic Hedgehog Signaling in Nervous System Development and Disease. [PDF]

, 2016
Sonic hedgehog (Shh) signaling occurs concurrently with the many processes that constitute nervous system development. Although Shh is mostly known for its proliferative and morphogenic action through its effects on neural stem cells and progenitors, it ...
Belgacem, Yesser H, Borodinsky, Laura N, Hamilton, Andrew M, Shim, Sangwoo, Spencer, Kira A   +4 more
core   +2 more sources

Facilitatory actions of guanidine on synaptic transmission in mammalian brain slices [PDF]

, 1979
Guanidine administration may be beneficial in the treatment of amyotrophic lateral sclerosis and related diseases; however, the actions of guanidine on the mammalian central nervous system have not been investigated.
Galvan, Martin, Grafe, Peter, Ten Bruggencate, Gerrit   +2 more
core   +1 more source

Differential in vitro infection of neural cells by astroviruses [PDF]

, 2019
Encephalitis remains a diagnostic conundrum in humans as over 50% of cases are managed without the identification of an etiology. Astroviruses have been detected from the central nervous system of mammals in association with disease, suggesting that this
Janowski, Andrew B, Klein, Robyn S, Wang, David   +2 more
core   +2 more sources

Value of determining the cerebrospinal fluid protein markers of amyloidosis and neurodegeneration in the diagnosis of vascular and neurodegenerative cognitive impairments

Неврология, нейропсихиатрия, психосоматика, 2013
The article presents data on different forms of moderate cognitive impairments (MCI) and the specific features of their transformation to dementia. Cerebrospinal fluid (CSF) was investigated in 60 patients with the amnestic and neurodynamic types of MCI,
Vladimir Yuryevich Lobzin, A Yu Emelin, M M Odinak, L A Alekseeva, N E Monakhova   +4 more
doaj   +1 more source

NOD1/RIP2 signalling enhances the microglia-driven inflammatory response and undergoes crosstalk with inflammatory cytokines to exacerbate brain damage following intracerebral haemorrhage in mice

Journal of Neuroinflammation, 2020
Background Secondary brain damage caused by the innate immune response and subsequent proinflammatory factor production is a major factor contributing to the high mortality of intracerebral haemorrhage (ICH).
Miao Wang, Xinchun Ye, Jinxia Hu, Qiuchen Zhao, Bingchen Lv, Weijing Ma, Weiwei Wang, Hanhan Yin, Qi Hao, Chao Zhou, Tao Zhang, Weifeng Wu, Yan Wang, Mingyue Zhou, Cong-hui Zhang, Guiyun Cui   +15 more
doaj   +1 more source

Peptides containing glutamine repeats as substrates for transglutaminase-catalyzed cross-linking: relevance to diseases of the nervous system.

Proceedings of the National Academy of Sciences of the United States of America, 1996
Many proteins contain reiterated glutamine residues, but polyglutamine of excessive length may result in human disease by conferring new properties on the protein containing it.
Pascal Kahlem, C. Terré, Howard Green, Philippe Djian   +3 more
semanticscholar   +1 more source

Protective potential of glucagon like peptide 2 (GLP-2) against the neurodegeneration [PDF]

, 2019
Neurodegeneration consists in loss of neuron specific types, pattern and distribution, leading to progressive dysfunctions of the central nervous system.
Amato, Antonella, Mulè, Flavia
core   +1 more source