Results 21 to 30 of about 716,091 (301)

Digestive symptoms in daily life of chronic adrenal insufficiency patients are similar to irritable bowel syndrome symptoms

open access: yesScientific Reports, 2021
Gastrointestinal symptoms are frequent in acute adrenal insufficiency. Although digestive symptoms can significantly reduce quality of life, they are rarely described in patients with treated chronic adrenal insufficiency (CAI).
L. Quénéhervé   +10 more
doaj   +1 more source

Effects of oxidative stress on hepatic encephalopathy pathogenesis in mice

open access: yesNature Communications, 2023
Oxidative stress plays a crucial role in the pathogenesis of hepatic encephalopathy (HE), but the mechanism remains unclear. GABAergic neurons in substantia nigra pars reticulata (SNr) contribute to the motor deficit of HE.
Yunhu Bai   +12 more
doaj   +1 more source

Criteria for diagnosis and classification of vascular cognitive impairment

open access: yesНеврология, нейропсихиатрия, психосоматика, 2022
Vascular cognitive impairment (VCI) is a very diverse group of conditions that differ in etiopathogenesis, severity, clinical picture, dynamics and severity of functional disorders.
A. Y. Emelin, V. Y. Lobzin
doaj   +1 more source

BYSL Promotes Glioblastoma Cell Migration, Invasion, and Mesenchymal Transition Through the GSK-3β/β-Catenin Signaling Pathway

open access: yesFrontiers in Oncology, 2020
BYSL, which encodes the human bystin protein, is a sensitive marker for astrocyte proliferation during brain damage and inflammation. Previous studies have revealed that BYSL has important roles in embryo implantation and prostate cancer infiltration ...
Zhuang Sha   +19 more
doaj   +1 more source

High expression of Bruton’s tyrosine kinase (BTK) is required for EGFR-induced NF-κB activation and predicts poor prognosis in human glioma

open access: yesJournal of Experimental & Clinical Cancer Research, 2017
Background Malignant glioma is the most common primary brain tumor in adults and has a poor prognosis. However, there are no effective targeted therapies for glioma patients.
Chenglong Yue   +8 more
doaj   +1 more source

β-catenin-mediated YAP signaling promotes human glioma growth

open access: yesJournal of Experimental & Clinical Cancer Research, 2017
Background Hippo/YAP pathway is known to be important for development, growth and organogenesis, and dysregulation of this pathway leads to tumor progression.We and others find that YAP is up-regulated in human gliomas and associated with worse prognosis
Yan Wang   +8 more
doaj   +1 more source

Saturated very long-chain fatty acids regulate macrophage plasticity and invasiveness

open access: yesJournal of Neuroinflammation, 2022
Saturated very long-chain fatty acids (VLCFA, ≥ C22), enriched in brain myelin and innate immune cells, accumulate in X-linked adrenoleukodystrophy (X-ALD) due to inherited dysfunction of the peroxisomal VLCFA transporter ABCD1.
Bettina Zierfuss   +15 more
doaj   +1 more source

Illness perception in patients with chronic migraine: cognitive, emotional and behavioral aspects

open access: yesНеврология, нейропсихиатрия, психосоматика, 2023
In patients with chronic migraine (CM), the illness perception includes three main aspects: cognitive (thoughts, beliefs, attitude towards pain), emotional (mood) and behavioral (pain coping strategies). The patient’s perception affects the course of CM,
V. A. Golovacheva   +3 more
doaj   +1 more source

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