Results 41 to 50 of about 1,567,602 (291)

Neural regulation of cardiovascular response to exercise: role of central command and peripheral afferents [PDF]

, 2014
During dynamic exercise, mechanisms controlling the cardiovascular apparatus operate to provide adequate oxygen to fulfill metabolic demand of exercising muscles and to guarantee metabolic end-products washout.
Crisafulli, A, Marongiu, E, Nobrega, ACL, O'Leary, D, Piepoli, MF, Silva, BM   +5 more
core   +4 more sources

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

Engineered oncolytic virus coated with anti-PD-1 and alendronate for ameliorating intratumoral T cell hypofunction

Experimental Hematology & Oncology
Background Glioblastoma is a highly aggressive and devastating primary brain tumor that is resistant to conventional therapies. Oncolytic viruses represent a promising therapeutic approach for glioblastoma by selectively lysing tumor cells and eliciting ...
Yufu Zhu, Xuefeng Zhang, Jiaqi Jin, Xiaoqian Wang, Yang Liu, Jian Gao, Diancheng Hang, Lin Fang, Hengzhu Zhang, Hongmei Liu   +9 more
doaj   +1 more source

Alpha- synuclein immunoreactivity in the enteric nervous system of human small intestine [PDF]

, 2018
Alpha-synuclein (α-syn) is a 140 amino acid protein, belonging to the synuclein family, expressed in mammalian neurons. Structural alterations of α-syn as well as its overexpression have been related to the onset and the progression of several human ...
Casini, Arianna, Chirletti, Piero, Vaccaro, Rosa   +2 more
core  

A Small Conductance Calcium-Activated K⁺ Channel in C. elegans, KCNL-2, Plays a Role in the Regulation of the Rate of Egg-Laying [PDF]

, 2013
In the nervous system of mice, small conductance calcium-activated potassium (SK) channels function to regulate neuronal excitability through the generation of a component of the medium afterhyperpolarization that follows action potentials.
A Calixto, A Singson, AC Gerlach, Cavita K. Chotoo, CC Mello, CI Bargmann, Cliff J. Luke, CM Fanger, CT Bond, D Fernández de Sevilla, Daniel C. Devor, ER Sawin, F Simmer, Gary A. Silverman, GM Herrera, IA Bany, J Kim, J Kyte, J Wolfart, JE Mendel, JG White, Jill C Bettinger, JJ Moresco, JP Adelman, JT Walter, KS Thorneloe, L Ségalat, M Dimitriadi, M Köhler, M Stocker, M Szatanik, M Zhang, MJ Miller, MR Klass, MR Koelle, MS Taylor, N Ringstad, PL Larsen, RM Empson, S Brenner, S Brähler, SE Bowden, TM Ishii, VG Shakkottai, WJ Joiner   +44 more
core   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

The WW domain presents a promising target for the development of PCIF1 agonists in the treatment of glioma

npj Precision Oncology
PCIF1 is currently the sole m6Am methyltransferase in mammalian mRNA, but it was initially named for the interaction between its WW domain and RNA polymerase II.
Jiale Yin, Gai Liu, Yu Zhou, Junbo Zhou, Mengzhe Guo, Zhiyuan Hu, Preethi Priyanka Musunuru, Rutong Yu, Qingming Meng, Shangfeng Gao   +9 more
doaj   +1 more source

Peroxisomal very long-chain fatty acid transport is targeted by herpesviruses and the antiviral host response

Communications Biology, 2022
Using Epstein-Barr virus (EBV) infection of human B cells, the importance of peroxisomal very long-chain fatty acid transport involving ABCD1 in viral infection and host defence is elucidated and applicable also to other herpes- and coronaviruses.
Isabelle Weinhofer, Agnieszka Buda, Markus Kunze, Zsofia Palfi, Matthäus Traunfellner, Sarah Hesse, Andrea Villoria-Gonzalez, Jörg Hofmann, Simon Hametner, Günther Regelsberger, Ann B. Moser, Florian Eichler, Stephan Kemp, Jan Bauer, Jörn-Sven Kühl, Sonja Forss-Petter, Johannes Berger   +16 more
doaj   +1 more source

Effect of hypovitaminosis D on the characteristics of chronic tension-type headache in women

Неврология, нейропсихиатрия, психосоматика, 2022
There is a growing body of evidence linking hypovitaminosis D with the prevalence and severity of various pain conditions. The effect of vitamin D levels on chronic tension type headache (CTTH) is almost unexplored.Objective: to investigate the effect of
A. A. Koloskova, O. V. Vorobyeva
doaj   +1 more source

Triggers for atrial fibrillation. the role of anxiety [PDF]

, 2019
Atrial fibrillation (AF) is the most widely recognized arrhythmia. Systemic arterial hypertension, diabetes, obesity, heart failure, and valvular heart diseases are major risk factors for the onset and progression of AF.
Ceccacci, Andrea, Fedele, Francesco, Lavalle, Carlo, Maestrini, Viviana, Mancone, Massimo, Maraone, Annalisa, Mariani, MARCO VALERIO, Pasquini, Massimo, Piro, Agostino, Severino, Paolo, Tarsitani, Lorenzo   +10 more
core   +1 more source