Results 51 to 60 of about 716,091 (301)
FEBS Open Bio, EarlyView.The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli +15 more
wiley +1 more source
ABCD1 Transporter Deficiency Results in Altered Cholesterol Homeostasis
Biomolecules, 2023 X-linked adrenoleukodystrophy (X-ALD), the most common peroxisomal disorder, is caused by mutations in the peroxisomal transporter ABCD1, resulting in the accumulation of very long-chain fatty acids (VLCFA).
Agnieszka Buda +9 more
doaj +1 more source
Lettsomian Lectures on Syphilis as a Cause of Disease of the Nervous System [PDF]
, 1874 W. H. Broadbent
+6 more sources
FEBS Open Bio, EarlyView.Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal +2 more
wiley +1 more source
The impact of frailty syndrome on skeletal muscle histology: preventive effects of exercise
FEBS Open Bio, EarlyView.Frailty syndrome exacerbates skeletal muscle degeneration via increased ECM deposition and myofiber loss. This study, using a murine model, demonstrates that endurance exercise attenuates these histopathological alterations, preserving muscle integrity. Findings support exercise as a viable strategy to counteract frailty‐induced musculoskeletal decline
Fujue Ji +3 more
wiley +1 more source
A Manual of Diseases of the Nervous System
The American Journal of Psychology, 1887 Contents.--v. 1. Diseases of the nerves and spinal cord.--v. 2. Diseases of the brain and cranial nerves. General and functional diseases of the nervous system. ; Mode of access: Internet.
openaire +2 more sources
Aging and Cancer, EarlyView.Aging weakens the blood–brain barrier (BBB), increasing susceptibility to CNS cancers and complicating treatment. This review examines BBB deterioration, its impact on drug delivery, and potential interventions like targeting neuroinflammation and advanced therapies.
Quang La, Aiman Baloch, David F. Lo
wiley +1 more source
Journal of Applied Clinical Medical Physics, EarlyView.Abstract The establishment of guidelines and curriculum standards for medical physics residency training is a critical component of setting expectations and competencies for the profession. Since the last publication of these standards, residency training has become integrated into the eligibility criteria for most medical physics certification bodies.
Jonathon A. Nye +16 more
wiley +1 more source
Cognitive impairment and mental disorders in patients with focal muscular dystonia
Неврология, нейропсихиатрия, психосоматика, 2019 Non-motor manifestations in focal muscular dystonia (FMD) have been little studied. Objective: to analyze the characteristics of cognitive impairment (CI) and mental disorders (MDs) in FMD. Patients and methods.
V. A. Tolmacheva +2 more
doaj +1 more source