Results 51 to 60 of about 1,542,715 (367)

Saturated very long-chain fatty acids regulate macrophage plasticity and invasiveness

Journal of Neuroinflammation, 2022
Saturated very long-chain fatty acids (VLCFA, ≥ C22), enriched in brain myelin and innate immune cells, accumulate in X-linked adrenoleukodystrophy (X-ALD) due to inherited dysfunction of the peroxisomal VLCFA transporter ABCD1.
Bettina Zierfuss, Agnieszka Buda, Andrea Villoria-González, Maxime Logist, Jure Fabjan, Patricia Parzer, Claire Battin, Streggi Vandersteene, Inge M. E. Dijkstra, Petra Waidhofer-Söllner, Katharina Grabmeier-Pfistershammer, Peter Steinberger, Stephan Kemp, Sonja Forss-Petter, Johannes Berger, Isabelle Weinhofer   +15 more
doaj   +1 more source

Review of Human Coronaviruses and Other Respiratory Viruses and their Neurological Impact on the Central Nervous System [PDF]

, 2020
Comprehensive reporting shows that some pathogens, including COVID-19, influenza A and SARS-CoV have sometimes caused pandemics and were linked to more serious diseases and death.
Haider, Monica, Thomas, M.D., Haider
core  

Distribution of choline acetyltransferase (ChAT) immunoreactivity in the brain of the teleost cyprinus carpio [PDF]

, 2018
Cholinergic systems play a role in basic cerebral functions and its dysfunction is associated with deficit in neurodegenerative disease. Mechanisms involved in human brain diseases, are often approached by using fish models, especially cyprinids, given ...
Casini, Arianna, Cioni, Carla, Toni, Mattia, Vaccaro, Rosa   +3 more
core   +2 more sources

Tolerogenic nanoparticles suppress central nervous system inflammation

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Current treatments for autoimmune diseases rely on nonspecific immunosuppression, risking important complications and limiting the long-term use of these approaches for the treatment of chronic human autoimmunity.
Jessica E. Kenison, Aditi Jhaveri, Zhaorong Li, Nikita Khadse, Emily C. Tjon, S. Tezza, D. Nowakowska, A. Plasencia, V. Stanton, D. Sherr, F. Quintana   +10 more
semanticscholar   +1 more source

Neural regulation of cardiovascular response to exercise: role of central command and peripheral afferents [PDF]

, 2014
During dynamic exercise, mechanisms controlling the cardiovascular apparatus operate to provide adequate oxygen to fulfill metabolic demand of exercising muscles and to guarantee metabolic end-products washout.
Crisafulli, A, Marongiu, E, Nobrega, ACL, O'Leary, D, Piepoli, MF, Silva, BM   +5 more
core   +4 more sources

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Engineered oncolytic virus coated with anti-PD-1 and alendronate for ameliorating intratumoral T cell hypofunction

Experimental Hematology & Oncology
Background Glioblastoma is a highly aggressive and devastating primary brain tumor that is resistant to conventional therapies. Oncolytic viruses represent a promising therapeutic approach for glioblastoma by selectively lysing tumor cells and eliciting ...
Yufu Zhu, Xuefeng Zhang, Jiaqi Jin, Xiaoqian Wang, Yang Liu, Jian Gao, Diancheng Hang, Lin Fang, Hengzhu Zhang, Hongmei Liu   +9 more
doaj   +1 more source

Peroxisomal very long-chain fatty acid transport is targeted by herpesviruses and the antiviral host response

Communications Biology, 2022
Using Epstein-Barr virus (EBV) infection of human B cells, the importance of peroxisomal very long-chain fatty acid transport involving ABCD1 in viral infection and host defence is elucidated and applicable also to other herpes- and coronaviruses.
Isabelle Weinhofer, Agnieszka Buda, Markus Kunze, Zsofia Palfi, Matthäus Traunfellner, Sarah Hesse, Andrea Villoria-Gonzalez, Jörg Hofmann, Simon Hametner, Günther Regelsberger, Ann B. Moser, Florian Eichler, Stephan Kemp, Jan Bauer, Jörn-Sven Kühl, Sonja Forss-Petter, Johannes Berger   +16 more
doaj   +1 more source

Effect of hypovitaminosis D on the characteristics of chronic tension-type headache in women

Неврология, нейропсихиатрия, психосоматика, 2022
There is a growing body of evidence linking hypovitaminosis D with the prevalence and severity of various pain conditions. The effect of vitamin D levels on chronic tension type headache (CTTH) is almost unexplored.Objective: to investigate the effect of
A. A. Koloskova, O. V. Vorobyeva
doaj   +1 more source

Alpha- synuclein immunoreactivity in the enteric nervous system of human small intestine [PDF]

, 2018
Alpha-synuclein (α-syn) is a 140 amino acid protein, belonging to the synuclein family, expressed in mammalian neurons. Structural alterations of α-syn as well as its overexpression have been related to the onset and the progression of several human ...
Casini, Arianna, Chirletti, Piero, Vaccaro, Rosa   +2 more
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