Results 71 to 80 of about 1,574,428 (338)

WNT signaling in neuronal maturation and synaptogenesis [PDF]

, 2013
The Wnt signaling pathway plays a role in the development of the central nervous system and growing evidence indicates that Wnts also regulates the structure and function of the adult nervous system.
Nibaldo C. Inestrosa, Silvana B. Rosso
core   +1 more source

Interplay between androgen and CXCR4 chemokine signaling in myelin repair

Acta Neuropathologica Communications
In men, reduced levels of testosterone are associated with the prevalence and progression of multiple sclerosis (MS), a chronic and disabling demyelinating disorder. Testosterone has been shown to promote myelin repair.
Narimène Asbelaoui, Charly Abi-Ghanem, Géraldine Schlecht-Louf, Hania Oukil, Cindy Degerny, The Netherlands Brain Bank, Michael Schumacher, Abdel Mouman Ghoumari   +7 more
doaj   +1 more source

Investigation of the peripheral inflammation (neutrophil–lymphocyte ratio) in two neurodegenerative diseases of the central nervous system [PDF]

, 2021
Sonat Pınar Kara, Bengü Altunan, Aysun Ünal   +2 more
openalex   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Triggers for atrial fibrillation. the role of anxiety [PDF]

, 2019
Atrial fibrillation (AF) is the most widely recognized arrhythmia. Systemic arterial hypertension, diabetes, obesity, heart failure, and valvular heart diseases are major risk factors for the onset and progression of AF.
Ceccacci, Andrea, Fedele, Francesco, Lavalle, Carlo, Maestrini, Viviana, Mancone, Massimo, Maraone, Annalisa, Mariani, MARCO VALERIO, Pasquini, Massimo, Piro, Agostino, Severino, Paolo, Tarsitani, Lorenzo   +10 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

NMR metabolomics of cerebrospinal fluid differentiates inflammatory diseases of the central nervous system [PDF]

, 2018
BACKGROUND: Myriad infectious and noninfectious causes of encephalomyelitis (EM) have similar clinical manifestations, presenting serious challenges to diagnosis and treatment.
Amzuta, Ioana G., Brunner, Andrew M., David, Dan, Encarnacion, Rafael, Fatteh, Naaz, Fernandez, Josefina, Foley, John F., French, Caitlin D., Hu, William T., Javaid, Waleed, Mishchuk, Darya O., Neilan, Anne M., Ondrush, Joanne M., Paez, Andres, Pan, Amy, Robbins, Gregory K., Slupsky, Carolyn M., Wheat, L. Joseph, Willoughby, Rodney E., Wong, Susan J.   +19 more
core   +3 more sources

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

Drug delivery in overcoming the blood-brain barrier: role of nasal mucosal grafting [PDF]

, 2017
The blood–brain barrier (BBB) plays a fundamental role in protecting and maintaining the homeostasis of the brain. For this reason, drug delivery to the brain is much more difficult than that to other compartments of the body. In order to bypass or cross
Carafa, Maria, Di Marzio, Luisa, Hanieh, PATRIZIA NADIA, Marianecci, Carlotta, Paolino, Donatella, Rinaldi, Federica   +5 more
core   +1 more source

A unified model for Duchenne muscular dystrophy gene involvement in cancer: context‐dependent tumour suppression and oncogenicity

FEBS Open Bio, EarlyView.
We propose a context‐dependent model where the Duchenne muscular dystrophy (DMD) gene acts as a tumour suppressor in aggressive tumours and as an oncogene in less aggressive ones. We propose this model as a unified framework to explain the opposing survival associations with DMD expression and to guide experimental exploration of the dual role of DMD ...
Lee Machado, Leanne Jones, Sonika Divakar, Michael Naidoo, Karen Anthony   +4 more
wiley   +1 more source