Results 51 to 60 of about 61,453 (305)

Moral Disengagement in Legal Judgments [PDF]

open access: yes, 2017
We investigated the role of moral disengagement in a legally-relevant judgment in this theoretically-driven empirical analysis. Moral disengagement is a social-cognitive phenomenon through which people reason their way toward harming others, presenting a
Tess M. S. Neal   +3 more
core   +2 more sources

Impaired Visual Disengagement in Autism: Can this be due to stimulus effects and inherent interest? [PDF]

open access: yes, 2011
Atypicalities in the disengagement of attention have been proposed to play a crucial role in the origins of autism. Yet to date, there is disagreement over the existence of these atypicalities, due to conflicting evidence.
MARSHALL, DAVID,R., Marshall, David R
core  

Hear me, see me, trust you – job burnout and disengagement of Australian aged care workers

open access: yes, 2022
Purpose: The themes that emerged from the qualitative data of a mixed methods study that explored the effects of leadership style on the job satisfaction of aged care workers.
Olley, Richard
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Moral disengagement as a self-regulatory process in sexual harassment perpetration at work: A preliminary conceptualisation. [PDF]

open access: yes, 2015
Sexual harassment is recognized as a widespread form of aggressive behavior with severe consequences for victims and organizations. Yet, contemporary research and theory focusing on the motives and cognition of sexual harassment perpetrators continues to
Page, Thomas, E.   +2 more
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

open access: yesFEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel   +8 more
wiley   +1 more source

The effects of moral disengagement mechanisms on doping likelihood are mediated by guilt and moderated by moral traits [PDF]

open access: yes, 2018
Objectives: We examined the effects of moral disengagement on doping likelihood and guilt, and determined whether the effects of moral disengagement on doping likelihood were mediated by guilt and moderated by moral traits.
Hurst, Philip   +3 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

The Process of Disengagement From Personal Goals

open access: yes, 2017
To date, it is not well understood how individuals disengage from goals. A recent approach suggests that disengagement is often preceded by an action crisis, a motivational conflict in which the individual is torn between holding on to and letting go of
Herrmann, Marcel   +7 more
core   +1 more source

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