Results 51 to 60 of about 209,845 (305)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Neuronal correlates of attention and its disengagement in the superior colliculus of rat

Frontiers in Integrative Neuroscience, 2015
Orienting attention to a new target requires prior disengagement of attention from the current focus. Previous studies indicate that the superior colliculus (SC) plays an important role in attention.
Nguyen eNgan, Jumpei eMatsumoto, Yusaku eTakamura, Anh eTran, Taketoshi eOno, Hisao eNishijo   +5 more
doaj   +1 more source

Stigma, Dissatisfaction, Disengagement and Intention To Quit: A Model Proposal

Yaşam Becerileri Psikoloji Dergisi, 2020
Stigma defines the process where a target’s attribute or set of attributes is devalued by an existing social group (Phelan, Link, & Dovidio, 2008). It is also expressed as an attribute which is discrediting in organizations. On the other side, Jones, and
Meltem AKCA, Burcu Ozge OZASLAN CALISKAN
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Attentional and Behavioral Disengagement as Coping Responses to Technostress and Financial Stress: An Experiment Based on Psychophysiological, Perceptual, and Behavioral Data

Frontiers in Neuroscience, 2022
Discontinuance of information systems (IS) is a common phenomenon. It is thus critical to understand the decision process and psychophysiological mechanisms that underlie the intention and corresponding behaviors to discontinue IS use, particularly ...
Marion Korosec-Serfaty, René Riedl, René Riedl, Sylvain Sénécal, Pierre-Majorique Léger   +4 more
doaj   +1 more source

Nurse moral disengagement [PDF]

Nursing Ethics, 2016
Background: Ethics is a founding component of the nursing profession; however, nurses sometimes find it difficult to constantly adhere to the required ethical standards. There is limited knowledge about the factors that cause a committed nurse to violate standards; moral disengagement, originally developed by Bandura, is an essential variable to ...
FIDA, Roberta, TRAMONTANO, CARLO, PACIELLO, MARINELLA, Kangasniemi, Mari, SILI, ALESSANDRO, Bobbio, Andrea, BARBARANELLI, Claudio   +6 more
openaire   +4 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Palestinian Refugees in Gaza [PDF]

, 2004
Events since Arthur Helton\u27s death - including the change in leadership of the Palestinian Authority and the Israeli proposal for disengagement from Gaza make it even timelier to examine some practical solutions.
Fagen, Patricia, Martin, Susan, Warner, John G.   +2 more
core   +1 more source

Atypical disengagement from faces and its modulation by the control of eye fixation in children with Autism Spectrum Disorder [PDF]

, 2011
By using the gap overlap task, we investigated disengagement from faces and objects in children (9–17 years old) with and without autism spectrum disorder (ASD) and its neurophysiological correlates.
A Klin, A Kylliäinen, A Senju, A Senju, American Psychiatric Association, American Psychiatric Association, Atsushi Senju, B Fischer, B Jemel, BA Brooks-Eidelberg, BM Nacewicz, C Gómez, C Kemner, CD Balaban, CF Norbury, D Kurtzberg, D Matsumoto, D Wechsler, DJ Simons, DP Munoz, DP Munoz, E Wojciulik, EC Dias, G Csibra, G Csibra, G Csibra, GW Humphreys, H Dairoku, Hironori Akechi, Hiroo Osanai, J McPartland, J Swettenham, J Theeuwes, JA Osterling, Japanese WISC-III Publication Committee, JN Geest Van der, JN Geest Van der, JP Morris, K Chawarska, K Chawarska, K Chawarska, K Nation, K O’Connor, K O’Connor, KA Pelphrey, KM Dalton, L Sterling, L Zwaigenbaum, M Bindemann, M Eimer, M Elsabbagh, M Junchöfer, MC Goldberg, MD Rutherford, MG Saslow, MH Johnson, MI Posner, MJ Taylor, MJ Taylor, N George, N Hadjikhani, N Hadjikhani, NJ Sasson, R Itier, R Landry, R Palermo, R VanRullen, S Bentin, SK Berument, SRH Langton, T Ro, T Ro, Toshikazu Hasegawa, V Bruce, W Jones, Y Kawakubo, Y Kawakubo, Yoshikuni Tojo, Yukiko Kikuchi, ZL Boraston   +79 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source