Results 51 to 60 of about 138,697 (306)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

From Citizenship Pressure to Pro-Group Unethical Behavior: The Dual-Stage Moderating Role of Self-Serving Political Will

Behavioral Sciences, 2023
Drawing upon social cognitive theory, our study proposes a dual-stage moderated mediation model that utilizes moral disengagement as the mediator and self-serving political will as the moderator to investigate whether, how, and when team-oriented ...
Hantai Zhang, Minqiao Hu, Xin Liu, Xuan Yu, Jinyu Xie   +4 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Link Between Cyberbullying Victimization and Perpetration Among Undergraduates: Mediating Effects of Trait Anger and Moral Disengagement

Psychology Research and Behavior Management, 2020
Guangbo Dou,1 Ying Xiang,2 Xiaohua Sun,3,* Liang Chen3,* 1College of Kinesiology, Shenyang Sport University, Shenyang City, Liaoning Province, People’s Republic of China; 2Department of Psychiatry, Dalian Rehabilitation Center, Dalian City ...
Dou G, Xiang Y, Sun X, Chen L
doaj  

Unraveling the Influential Mechanisms of Social Commerce Overloads on User Disengagement: The Buffer Effect of Guanxi

Psychology Research and Behavior Management, 2023
Jue Wang,1 Shaoting Wen,2 Jiaolong Xue3 1Business School, Open University of Henan, Zhengzhou, People’s Republic of China; 2School of Management, Guangdong Ocean University, Zhanjiang, People’s Republic of China; 3Business School, Sichuan University ...
Wang J, Wen S, Xue J
doaj  

Political Theory, Political Science, And The End Of Civic Engagement [PDF]

, 2009
Within a span of fifteen years civic engagement has become a cottage industry in political science and political theory, but the term has now outlived its usefulness and exemplifies Giovanni Sartori\u27s worry about conceptual stretching.
Arendt, Arendt, Arendt, Arendt, Arendt, Arendt, Arendt, Barber, Barber, Ben Berger, Bennett, Berman, Bloom, Brown, Chambers, Cohen, Durkheim, Ehrenhalt, Feinberg, Gans, Gough, Havel, Hicks, Hont, Irwin, James, Jones, Kateb, King, King, Kornhauser, Ladd, Ladd, Levinger, Levinson, Lord, Maimonides, Marx, McGann, Norris, Oldenburg, Pateman, Pitkin, Putnam, Putnam, Rosenblum, Rosenstone, Sandel, Schudson, Sennett, Shaftesbury, Shklar, Shumer, Skocpol, Taylor, Tocqueville, Tocqueville, Tönnies, Valelly, Verba, Warren, Wuthnow   +61 more
core   +2 more sources

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source

Stigmatization and Interpersonal Deviance Behaviors of Tour Guides: The Influence of Self-Identity Threat and Moral Disengagement

Frontiers in Psychology, 2022
Severe tour guide stigma is a significant problem hindering tourism development. Based on self-identity threat and moral disengagement theory, this study analyzed the relationship between tour guide stigmatization and tour guides’ interpersonal deviance ...
Aimin Deng, Wenxing Liu, Anna Long, Yanghao Zhu, Kai Gao   +4 more
doaj   +1 more source

Perceptual Control Theory for Engagement and Disengagement of Users in Public Spaces [PDF]

, 2017
This paper presents Perceptual Control Theory-a model that explains behaviour as an attempt to keep sensory inputs in a desired range and demonstrates that it can be used to develop an approach designed to make robots capable of human interaction.
Deshmukh, Amol, Foster, Mary Ellen, Vinciarelli, Alessandro   +2 more
core   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source