Results 91 to 100 of about 290,563 (234)

Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends

open access: yesMed Research, EarlyView.
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
wiley   +1 more source

Genome‐Wide Assessment Reveals Ancestral Differences in Homozygosity Patterns Potentially Linked to Parkinson's Disease Etiology

open access: yesMovement Disorders, EarlyView.
Abstract Background Recessive genetic variation and extended runs of homozygosity (ROHs) may contribute to the unexplained heritability of Parkinson's disease (PD), particularly in diverse and understudied populations. Objective We conducted the first large‐scale, multi‐ancestral investigation of PD to examine the impact of genome‐wide homozygosity on ...
Kathryn Step   +680 more
wiley   +1 more source

Correlation Between Gut Microbiota, Metabolites, and Diabetic Complications: A Two‐Sample Mendelian Randomization Study

open access: yesMedicine Advances, EarlyView.
Fang et al. demonstrate a significant causal relationship among gut microbiota, gut metabolites, and diabetic complications, highlighting a biological link underlying mechanisms of diabetic vascular diseases. These findings provide important implications for future therapeutic strategy and risk prediction.
Jiaxi Fang   +6 more
wiley   +1 more source

Disequilibrium [PDF]

open access: yesJournal of Medical Humanities, 2019
openaire   +1 more source

Genetically predicted KIR2DS4 mediate the association between gut microbe K10 and osteoporosis fractures: A mediation Mendelian randomization study

open access: yesPM&R, EarlyView.
Abstract Background Osteoporosis fractures pose a significant public health concern, leading to substantial morbidity and mortality rates. The emerging evidence on the potential link between gut microbiota, proteins, and osteoporosis fractures suggests a complex relationship that warrants further investigation.
Qiong Wang   +6 more
wiley   +1 more source

Firm Value and the mis-use of the CAPM for valuation and decision making [PDF]

open access: yes
This paper shows that a decision maker using the CAPM for valuing firms and making decisions may contradict Modigliani and Miller’s Proposition I, if he adopts the widely-accepted disequilibrium NPV.
Magni, Carlo Alberto
core   +1 more source

Cryostratigraphy of Rhythmic Segregated Ice in Colluvium and Implications for Permafrost Slope Stability

open access: yesPermafrost and Periglacial Processes, EarlyView.
ABSTRACT The amount and stratigraphic setting of ground ice in permafrost slopes is a key control on the style and magnitude of permafrost mass wasting. Understanding the spatial and stratigraphic variations in ground ice distribution on permafrost slopes is therefore a fundamental property in assessing the stability of permafrost hillslopes.
Joseph M. Young   +2 more
wiley   +1 more source

Spatial Variability of Permafrost and Active Layer Thickness in a Forested Hillslope of the Taiga Shield

open access: yesPermafrost and Periglacial Processes, EarlyView.
ABSTRACT Under continued climate warming, understanding present‐day permafrost distribution and the controls on ground thaw are critical for predicting permafrost thaw trajectories and associated implications. This study presents a high‐resolution investigation of permafrost extent and active layer thickness (ALT) across a coniferous forested hillslope
Alana Muenchrath   +2 more
wiley   +1 more source

Range‐wide sampling reveals cryptic lineages but largely conserved mycorrhizal associations in the Japanese fairy lantern Thismia kobensis

open access: yesPLANTS, PEOPLE, PLANET, EarlyView.
The jewel‐like flowers of Thismia are as rare as they are beautiful, often recorded from only a single site per species. Access to 15 populations of T. kobensis has enabled an uncommon, range‐wide assessment of morphology, genetics, and fungal partners. Our analyses showed that T.
Kenji Suetsugu   +4 more
wiley   +1 more source

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