Shared genetic and molecular architecture between neurodevelopmental disorders and type 1 diabetes
Abstract Epidemiological and clinical studies have suggested possible associations between type 1 diabetes (T1D) and neurodevelopmental disorders (NDDs), but these relationships remain inconsistent across disorders and populations. To clarify whether such mixed findings, we investigated the genetic architecture linking T1D with autism spectrum disorder
Jingxuan Zhang +3 more
wiley +1 more source
Empathic Disequilibrium in Autistic Traits and CU Traits: Investigating Empathy Imbalance in Children. [PDF]
Georgiou G +3 more
europepmc +1 more source
Paradoxical Alopecia Areata Induced by IL‐17 and IL‐23 Inhibitors: A Systematic Review
This systematic review identifies consistent clinical patterns of alopecia areata associated with IL‐17 and IL‐23 inhibitors, most frequently involving secukinumab and ustekinumab. Disease severity varied widely, and management often required biologic discontinuation or therapeutic switching.
Isabella Kamholtz +2 more
wiley +1 more source
A comprehensive genomic characterization of Nellore cattle. [PDF]
Campos G +5 more
europepmc +1 more source
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) is increasingly prevalent among lean Asian populations, yet effective strategies for identifying high‐risk individuals remain limited. We investigated the associations of body fat percentage (BF%) and the triglyceride‐glucose (TyG) index with lean MASLD and evaluated their ...
Xiang‐Ran Kong +4 more
wiley +1 more source
ABSTRACT Promoting the green transition of farmland use (GTFU) in major grain‐producing areas is essential for ensuring food security and advancing sustainable agricultural development. However, existing studies on GTFU have predominantly relied on static cross‐sectional analyses, with insufficient attention paid to its nonlinear driving mechanisms. To
Zhixian Sun +5 more
wiley +1 more source
Identification and genomic location of resistance to bacterial leaf streak of barley. [PDF]
Velasco DD +5 more
europepmc +1 more source
Candidate-gene-based study of CYP3A-related single-nucleotide polymorphisms using 4β-hydroxycholesterol/cholesterol ratio as biomarker in a Japanese cohort. [PDF]
Tanaka R +14 more
europepmc +1 more source
Effect of COMT and UGT1A Variants on Clinical Response to Opicapone in Parkinson's Disease
Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disease. Symptomatic treatment is based on dopaminergic replacement. With disease progression, the initial benefit of levodopa becomes inconsistent, and motor complications emerge.
Elena Ojeda‐Lepe +15 more
wiley +1 more source
High-density single nucleotide polymorphism markers analysis reveals the genetic diversity and population structure in tropical highland maize (Zea mays L.) inbred lines. [PDF]
Gebre WT +3 more
europepmc +1 more source

