Results 141 to 150 of about 174,103 (341)

The causal relationship between systemic lupus erythematosus and juvenile myoclonic epilepsy: A Mendelian randomization study and mediation analysis

Ibrain, Volume 11, Issue 1, Page 98-105, Spring 2025.
Mendelian randomization (MR) studies were conducted using the inverse‐variance weighted (IVW) method, MR‐Egger and weighted median on juvenile myoclonic epilepsy (JME), and systemic lupus erythematosus (SLE) data from the Integrative Epidemiology Unit (IEU) Open genome‐wide association study (GWAS) database and the International League Against Epilepsy
Sirui Chen, Ningning Zhang, Ruirui Zhang, Lan Zhang, Dadong Luo, Junqiang Li, Yaqing Liu, Yunan Wang, Xinyue Duan, Xin Tian, Tiancheng Wang   +10 more
wiley   +1 more source

Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk Scores

bioRxiv, 2015
B. Vilhjálmsson, Jian Yang, H. Finucane, A. Gusev, S. Lindström, S. Ripke, G. Genovese, Po-Ru Loh, G. Bhatia, R. Do, Tristan J. Hayeck, H. Won, S. Kathiresan, M. Pato, C. Pato, R. Tamimi, E. Stahl, N. Zaitlen, B. Pasaniuc, M. Schierup, P. D. De Jager, N. Patsopoulos, S. Mccarroll, M. Daly, S. Purcell, D. Chasman, B. Neale, M. Goddard, P. Visscher, P. Kraft, N. Patterson, A. Price   +31 more
semanticscholar   +1 more source

Real‐world study on fluoropyrimidine‐related toxicity outcomes in cancer patients with select DPYD variant alleles that received DPYD genotype‐guided dosing

International Journal of Cancer, EarlyView.
What's New? Fluoropyrimidines, a key component of chemotherapy regimens for a variety of solid tumors, can cause severe toxicity. Patients who have specific genetic variants in the DPYD gene, which encodes an enzyme that inactivates fluoropyrimidines, have increased susceptibility to this toxicity.
Sofía L. J. Peeters, Didier Meulendijks, Zerina Kadric, Sara Ibrovic, Geert‐Jan Creemers, Vanja Milosevic, Matthijs van de Poll, Lieke H. J. Simkens, Birgit A. L. M. Deiman, Hans Gelderblom, Henk‐Jan Guchelaar, Anna M. J. Thijs, Maarten J. Deenen   +12 more
wiley   +1 more source

Clinical course of five patients definitively diagnosed with idiopathic perilymphatic fistula treated with transcanal endoscopic ear surgery

Frontiers in Neurology
ObjectivesAn idiopathic perilymphatic fistula (PLF) can be difficult to diagnose because patients present with sudden sensorineural hearing loss (SSHL) and/or vestibular symptoms without any preceding events.
Toshinori Kubota, Toshinori Kubota, Tsukasa Ito, Takatoshi Furukawa, Takatoshi Furukawa, Hirooki Matsui, Takanari Goto, Chikako Shinkawa, Han Matsuda, Tetsuo Ikezono, Seiji Kakehata   +10 more
doaj   +1 more source

LINKAGE DISEQUILIBRIUM AND HETEROSIS IN EXPERIMENTAL POPULATIONS OF DROSOPHILA MELANOGASTER WITH PARTICULAR REFERENCE TO THE SEPIA GENE

, 1964
Sadao I. Chigusa, Terumi Mukai
openalex   +2 more sources

Development of associative overdominance through linkage disequilibrium in finite populations [PDF]

, 1970
Tomoko Ohta, Makoto Kimura
openalex   +1 more source

Disequilibrium Chemistry

, 2016
Oral presentation given at the ExoClimes 2016, held on August 1-4th, 2016 at Quest University (Squamish, Canada).
openaire   +1 more source

The mitochondrial DNA copy number and ovary‐related reproductive disorders: A bidirectional two‐sample Mendelian randomization study

International Journal of Gynecology &Obstetrics, Volume 169, Issue 1, Page 112-120, April 2025.
Abstract Objective In the present study, a bidirectional two‐sample Mendelian randomization approach was utilized to explore potential causal relationships between mitochondrial DNA copy number (mtDNA‐CN) and ovary‐related reproductive disorders (ORRDs), including ovarian dysfunction, ovarian cyst, polycystic ovary syndrome (PCOS), premature ovarian ...
Ke Peng, Xiao Han, Congquan Wu, Qiaowen Lu, Shujun Gao   +4 more
wiley   +1 more source

Lipid metabolism and inflammation as key drivers in preterm birth: A comprehensive analysis

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To investigate the alterations in lipid metabolites and circulating inflammatory factors associated with preterm birth, elucidate their interactions, and uncover the underlying pathophysiologic mechanisms. By identifying potential predictive biomarkers and informing the development of effective therapeutic interventions, this ...
Shu Xiao, ChaoChao Wei
wiley   +1 more source

Disequilibrium in the malate dehydrogenase reaction in rat liver mitochondria in vivo [PDF]

, 1972
D. F. Heath, John C. Phillips
openalex   +1 more source