Results 61 to 70 of about 64,863 (301)

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

open access: yesAdvanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis   +32 more
wiley   +1 more source

Studies of the Toxic Interactions of Disinfection By-Products [PDF]

open access: yesEnvironmental Health Perspectives, 1986
A large number and variety of compounds are formed in the process of chlorinating drinking water. The classes of compounds formed include trihalomethanes, haloacetic acids, haloacetonitriles, halophenols, and halopropanones. Many of the compounds have been shown to be toxic and are currently being further evaluated by the U.S.
R D, Laurie   +3 more
openaire   +3 more sources

CONTROLLING DISINFECTION BY-PRODUCT FORMATION WITH GAC ADSORPTION AND POTENTIAL ROLE FOR UV-LEDS WITH CHLORINE

open access: yes, 2023
The J. Douglas Kline Water Supply Plant (JDKWSP) is one of the main drinking water facilities in Halifax, Nova Scotia. The treatment process of JDKWSP is characterized by direct anthracite-sand filtration and chlorine disinfection. Natural organic matter
Jiang, Xuedongzi
core  

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

open access: yesAdvanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu   +10 more
wiley   +1 more source

Characterization of iodinated disinfection by-products in chlorinated and chloraminated waters using Orbitrap based gas chromatography-mass spectrometry [PDF]

open access: yes, 2016
Recent developments in gas chromatography (GC)-mass spectrometry (MS) have opened up the possibility to use the high resolution-accurate mass (HRAM) Orbitrap mass analyzer to further characterize the volatile and semivolatile fractions of environmental ...
Richardson, Susan D.   +4 more
core   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

open access: yesAdvanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong   +14 more
wiley   +1 more source

Formation of Haloforms during Chlorination of Natural Waters

open access: yesActa Polytechnica, 2002
Recent drinking water regulations have lowered the standards for disinfection by-products and have added new disinfection by-products for regulation. Natural organic matter (NOM), mainly humic compounds, plays a major role in the formation of undesirable
A. Grünwald   +3 more
doaj  

Occurrence of disinfectant by-products during the sequential disinfection process

open access: yesDesalination and Water Treatment, 2013
Abstract Sequential disinfection is considered a viable treatment option for the effective inactivation of pathogenic micro-organisms such as oocysts of protozoan parasites (e.g. Cryptosporidium parvum etc.) and spores of vegetative bacteria (e.g.
Eunkyung Jang   +4 more
openaire   +1 more source

The Behaviour of Haloacetic Acids in Distribution Zones in Scotland [PDF]

open access: yes, 2014
HAAs are the second most prevalent class of DBPs after THMs in chlorinated drinking water and are of concern due to their potential human health risk. Their concentrations in drinking water are regulated by the US Environmental Protection Agency (US EPA)
Agori, Georgia
core  

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

open access: yesAdvanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang   +9 more
wiley   +1 more source

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