Results 81 to 90 of about 64,863 (301)

Astrocytic Phenotypic Switching in Posterior Piriform Cortex Orchestrates Bone Cancer Pain–Depression Comorbidity via Purinergic–Noradrenergic Signaling

Advanced Science, EarlyView.
Bone cancer pain and depression share a common origin: astrocytic A2‐to‐A1 transition in the posterior piriform cortex. This phenotypic shift disrupts the ATP–adenosine–A2AR–norepinephrine axis, simultaneously driving nociceptive and affective dysfunction.
Jiang‐Ping Liu, Jun‐Han Zhang, Zhi‐Xuan Tan, Wei‐Bing Yan, Ya‐Ru Yuan, Yao Liu, Bing‐Di Wei, Meng‐Qi Ding, Zhuo‐Min Fu, Ying Liu, An‐Qi Wang, Lin Ma, Yong‐Hong Li, Er‐Qing Chai, Chao‐Jun Wei   +14 more
wiley   +1 more source

Associations of exposure to disinfection by-products with blood coagulation parameters among women: Results from the Tongji reproductive and environmental (TREE) study

Ecotoxicology and Environmental Safety
Background: Experimental studies have shown that disinfection byproducts (DBPs) induce coagulotoxicity, but human evidence is scarce. Objective: This study aimed to explore the relationships of DBP exposures with blood coagulation parameters.
Fei-Peng Cui, Yu Miao, A.-Xue Liu, Yan-Ling Deng, Chong Liu, Min Zhang, Jia-Yue Zeng, Yu-Feng Li, Hai-Yi Liu, Chang-Jiang Liu, Qiang Zeng   +10 more
doaj   +1 more source

Chlorine dioxine DBPs (disinfection by-products) in drinking water

Journal of Biological Research, 2013
Since the 1970s it has been well known that, though water for human consumption is generally disinfected before being distributed along the network, the use of chemicals results in the formation of many different Disinfection By-Products (DBPs).
C. Lasagna, E. Raffo, M. Bianchi, L. Pocaterra   +3 more
doaj   +1 more source

Chemical and microbiological risk-based optimization of disinfection and monitoring: a meta-model approach [PDF]

The proper operation of drinking water distribution networks (DWDN) requires an optimal equilibrium between chemical and microbiological risk. In disinfected DWDNs a trade-off needs to be found in setting the concentration of residual disinfectant at the
Antonelli M., Cantoni B., Epifani I., Matracchi M.   +3 more
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Introgressed Variation in TaMYB7‐A1 Drives Graded Dormancy and Climate‐Adaptive Pre‐Harvest Sprouting Resistance in Wheat

Advanced Science, EarlyView.
TaMYB7‐A1 directly activates TaABI5 to enhance ABA signaling and regulate ABA‐GA homeostasis, enforcing seed dormancy. Its superior allele, derived from wild einkorn introgression, harbors a MITE insertion that elevates expression and two amino acid substitutions that enhance transcriptional activity, collectively generating graded PHS resistance for ...
Hao Wang, Dongzhi Wang, Yafei Guo, Qi Zheng, Min Zhang, James Simmonds, Jian Hou, Xuemei Liu, Xuelei Lin, Xiaomin Bie, Xiansheng Zhang, Xiaohui Li, Yuan Chen, Xueyong Zhang, Cristobal Uauy, Fei Lu, Chengcai Chu, Zhixi Tian, Jun Xiao   +18 more
wiley   +1 more source

Comparing the efficiencies of different commercial cleaning products in reducing the growth of bacterial flora within the school environment [PDF]

, 2011
The aims of this extended essay are to identify what types of bacteria are present at school environment and what type of cleaning product is the most effective at decreasing their growth when the surfaces are cleaned manually.
Sayınalp, Başak
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Lilrb4a Suppression Reprograms Microglia to Mitigate APOE4‐Associated Amyloid Plaques and Cerebral Amyloid Angiopathy in Association With a PPAR‐Linked Pro‐Clearance State

Advanced Science, EarlyView.
Targeting Lilrb4a in Apolipoprotein E4 (APOE4)‐associated Alzheimer's disease (AD) reprograms microglia toward a beneficial, phagocytic state. Genetic deletion or antisense inhibition of Lilrb4a suppresses p‐SHP2/NF‐κB/STAT1 signaling, restores PPAR‐linked lipid and energy metabolism, and reduces amyloid plaque burden and cerebral amyloid angiopathy ...
Changxu Nie, Ruixi Yang, Xiaotong Wang, Ping Jia, Xueqi Zhang, Yaqi Dai, Xue Bai, Sijia Duan, Yufeng Li, Peng Zheng, Xin Tian, Li Jiang, Chao Wang   +12 more
wiley   +1 more source

Monitoring and optimization of wastewater disinfection processes for ecosystem preservation [PDF]

A year-long monitoring initiative in northern Italy evaluated wastewater disinfection efficiency on E. coli and its impacts on the aquatic environment of the surface recipients, in terms of microbiological quality and ecotoxicity.
Antonelli M., Cantoni B., Penserini L., Bastante B.   +3 more
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Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, EarlyView.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Natural Organic Matter Removal for Disinfection By-Products Control in Climate Change Resilient Drinking Water Treatment [PDF]

Despite extensive experience in disinfected drinking water supply systems, challenges related to disinfection by-products (DBPs) formation still remain, especially considering higher water temperatures and content of natural organic matter (NOM). As part
Antonelli M., Cantoni B., Riva L., Stefanoni M., Punta C.   +4 more
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