Results 41 to 50 of about 102,816 (209)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

LOWER TO MIDDLE MIOCENE MOLLUSC ASSEMBLAGES FROM THE TORINO HILLS (NW ITALY): SYNTHESIS OF NEW DATA AND CHRONOSTRATIGRAPHICAL ARRANGEMENT

Rivista Italiana di Paleontologia e Stratigrafia, 2009
The goal of this study is to correlate in chronostratigraphic order the fossil assemblages of selected, historical Lower and Middle Miocene localities of the Torino Hills. More than 18,000 specimens have been classified and assigned to 798 taxa (cf. Tab.
MARTA ZUNINO, GIULIO PAVIA
doaj   +1 more source

Refined conformal spectra in the dimer model

, 2012
Working with Lieb's transfer matrix for the dimer model, we point out that the full set of dimer configurations may be partitioned into disjoint subsets (sectors) closed under the action of the transfer matrix. These sectors are labelled by an integer or
Dubédat J, Jacobsen J L, Jeng M, Jørgen Rasmussen, Kausch H G, Kleban P, McCoy B W, Morin-Duchesne A, Morin-Duchesne A, Pearce P A, Pearce P A, Pearce P A, Philippe Ruelle, Poghosyan V S, Ruelle P, Temperley H N V   +15 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

A global numerical classification of the soil surface layer

Geoderma
The quest for a global soil classification system has been a long-standing challenge in soil science. There currently exist two, seemingly disjoint, global soil classification systems, the USDA Soil Taxonomy and the World Reference Base for Soil ...
Alexandre M.J.-C. Wadoux, Alex B. McBratney   +1 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Detecting rare structural variation in evolving microbial populations from new sequence junctions using breseq

Frontiers in Genetics, 2015
New mutations leading to structural variation (SV) in genomes — in the form of mobile element insertions, large deletions, gene duplications, and other chromosomal rearrangements — can play a key role in microbial evolution.
Daniel E Deatherage, Charles C Traverse, Lindsey N Wolf, Jeffrey E Barrick   +3 more
doaj   +1 more source

A Dichotomic Analysis of the Surprise Examination Paradox [PDF]

, 2005
This paper proposes a new framework to solve the surprise examination paradox. I survey preliminary the main contributions to the literature related to the paradox. I introduce then a distinction between a monist and a dichotomic analysis of the paradox.
Franceschi, Paul
core   +1 more source