Results 51 to 60 of about 2,014,535 (251)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

A global numerical classification of the soil surface layer

Geoderma
The quest for a global soil classification system has been a long-standing challenge in soil science. There currently exist two, seemingly disjoint, global soil classification systems, the USDA Soil Taxonomy and the World Reference Base for Soil ...
Alexandre M.J.-C. Wadoux, Alex B. McBratney   +1 more
doaj   +1 more source

Node Disjoint Multipath Routing Approach for Controlling Congestion in MANETs [PDF]

, 2012
Mobile Ad hoc Networks are highly dynamic networks. Quality of Service (QoS) routing in such networks is usually limited by the network breakage due to either node mobility or energy depletion of the mobile nodes. Nodedisjoint routing becomes inessential
Mr. Gaurav Deshmukh, Dr. Abhishek Bande
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

LOWER TO MIDDLE MIOCENE MOLLUSC ASSEMBLAGES FROM THE TORINO HILLS (NW ITALY): SYNTHESIS OF NEW DATA AND CHRONOSTRATIGRAPHICAL ARRANGEMENT

Rivista Italiana di Paleontologia e Stratigrafia, 2009
The goal of this study is to correlate in chronostratigraphic order the fossil assemblages of selected, historical Lower and Middle Miocene localities of the Torino Hills. More than 18,000 specimens have been classified and assigned to 798 taxa (cf. Tab.
MARTA ZUNINO, GIULIO PAVIA
doaj   +1 more source

Kernel bounds for disjoint cycles and disjoint paths [PDF]

, 2011
In this paper, we show that the problems Disjoint Cycles and Disjoint Paths do not have polynomial kernels, unless NP⊆coNP/poly. Thus, these problems do not allow polynomial time preprocessing that results in instances whose size is bounded by a ...
Thomassé, Stéphan, Stéphan Thomassé, Hans L. Bodlaender, Anders Yeo, Bodlaender, Hans L., Yeo, Anders   +5 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A micro-perspective on variation and universals [PDF]

, 2017
This paper approaches the questions raised in the workshop description surrounding universals and variation from the perspective of microvariation. Throughout this document we frequently refer to van Craenenbroeck and van Koppen (2016) (henceforth VCVK),
van Koppen, J.M., van Craenenbroeck, Jeroen, LS BZ Variatielinguistiek vh Nederlands, ILS Variation   +3 more
core  

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source