Results 71 to 80 of about 2,014,535 (251)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Vision Transformers in Person Re-Identification: A Review
IEEE AccessVision transformers (ViTs) have emerged as the dominant architecture for person re-identification (Re-ID)—the task of matching individuals across spatially disjoint surveillance cameras in the face of substantial variation in viewpoint, lighting ...
Baris Unver +3 more
doaj +1 more source
On the Two-Equal-Disjoint Path Cover Problem of Twisted Cubes [PDF]
, 2009 [[abstract]]Embedding of paths have attracted much attention in the parallel processing. Many-to-many communication is one of the most central issues in various interconnection networks.
Pao-Lien Lai; Hong-Chun Hsu
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Homeostatic Control of the Thyroid Pituitary Axis: Perspectives for Diagnosis and Treatment
Frontiers in Endocrinology, 2015 The long-held concept of a proportional negative feedback control between the thyroid and pituitary gland requires reconsideration in the light of more recent studies.
Rudolf eHoermann +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
NeuroImage: Clinical, 2019 Cerebrospinal fluid (CSF) YKL40 and sTREM2 are astroglial and microglial activity biomarkers, respectively. We assessed whether CSF YKL40 and sTREM2 baseline levels are associated with longitudinal brain volume and diffusivity changes in cognitively ...
Carles Falcon +9 more
doaj +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Weighted Shifts and Disjoint Hypercyclicity
, 2014 We give characterizations for finite collections of disjoint hypercyclic weighted shift operators, both in the unilateral and bilateral cases. It follows that some well-known results about the dynamics of an operator fail to hold true in the disjoint ...
Martin, Ozgur +2 more
core +2 more sources
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source