Results 91 to 100 of about 2,014,535 (251)

Disjoint NP-pairs [PDF]

open access: yes, 2003
We study the question of whether the class DisNP of disjoint pairs (A, B) of NP-sets contains a complete pair. The question relates to the question of whether optimal proof systems exist, and we relate it to the previously studied question of whether ...
Selman, Alan L.   +7 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

A Multi-Level Expressive Voice Cloning Method Based on Adaptive Grouped Code Modeling

open access: yesIEEE Access
Personalized voice cloning increasingly requires not only high speaker fidelity but also fine-grained control over rhythm, pitch, intensity, and expressive prosody.
Yan Zhu, Rui Zhou, Gang Chen
doaj   +1 more source

Disjoint Essential Cycles [PDF]

open access: yes, 1996
Graphs that have two disjoint noncontractible cycles in every possible embedding in surfaces are characterized. Similar characterization is given for the class of graphs whose orientable embeddings (embeddings in surfaces different from the projective ...
Robertson, Neil   +3 more
core   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

When synchrony meets diachrony : The negation system of Fɛʔfɛʔ in the light of the Jespersen Cycle [PDF]

open access: yes, 2015
This dissertation is concerned with synchronic variation as the reflection and residue of language change. The empirical focus is the negation system of Fɛʔfɛʔ.
Sub Overig UiLOTS   +2 more
core   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

Real-time modelling of a pandemic influenza outbreak

open access: yesHealth Technology Assessment, 2017
Background: Real-time modelling is an essential component of the public health response to an outbreak of pandemic influenza in the UK. A model for epidemic reconstruction based on realistic epidemic surveillance data has been developed, but this model ...
Paul J Birrell   +4 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Pseudorelative, gerundi e infiniti nelle varietà romanze: affinità (solo) superficiali e corrispondenze strutturali [PDF]

open access: yes, 2013
The main topic of this dissertation is a comparison among sentential predicative constructions in the Romance languages. Whereas Pseudo-relative clauses are almost universally used in the Romance domain (with some parametrical differences), predicative ...
Casalicchio, Jan, ILS Variation
core   +1 more source

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