Results 81 to 90 of about 2,014,535 (251)

Disjoint Supercyclic Weighted Shifts

open access: yes, 2016
Complementing the existing literature in d-hypercyclicity, we characterize disjoint supercyclicity for a finite family of weighted shift operators.
Martin, Ozgur, Sanders, Rebecca
core   +2 more sources

Eliciting Big Data From Small, Young, or Non-standard Languages: 10 Experimental Challenges [PDF]

open access: yes, 2019
The aim of this work is to identify and analyze a set of challenges that are likely to be encountered when one embarks on fieldwork in linguistic communities that feature small, young, and/or non-standard languages with a goal to elicit big sets of rich ...
Leivada, Evelina   +9 more
core   +2 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Beyond Accuracy: Auditing Image Forgery Localization via Scene-Disjoint Evaluation and XAI Faithfulness

open access: yesIEEE Access
Current image forgery localization benchmarks can be affected by an evaluation failure we termed the Metric Trap, wherein high pixel-level accuracy masks a model’s reliance on spurious boundary artifacts rather than semantically meaningful ...
Samer Aoudi   +3 more
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Do languages spoken in multilingual communities converge? A case study of reflexivity marking in Mano and Kpelle

open access: yesLinguistics
This paper explores variation in the patterns of reflexivity marking in the Mano language and possible influence from the Kpelle language by using an experimental design with a picture questionnaire. While Kpelle does not have a morphological distinction
Khachaturyan Maria   +2 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

AB-SAM: A SAM-Based Asymmetric Boundary-Aware Model for the Semantic Segmentation of Small and Medium-Sized Landslides

open access: yesGeomatics
Small- and medium-sized landslides frequently occur in clusters and exhibit fragmented morphologies, irregular boundaries, and spectral characteristics similar to surrounding roads, bare soil, and sparsely vegetated surfaces, making their automated ...
Jiting Tang   +9 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

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