Results 61 to 70 of about 2,014,535 (251)
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Optimal Link-Disjoint Node-“Somewhat Disjoint” Paths
, 2016 Network survivability has been recognized as an issue of major importance in terms of security, stability and prosperity. A crucial research problem in this context is the identification of suitable pairs of disjoint paths.
Rottenstreich, Ori +4 more
core +2 more sources
Interconnection networks for parallel and distributed computing [PDF]
, 2008 Parallel computers are generally either shared-memory machines or distributed- memory machines. There are currently technological limitations on shared-memory architectures and so parallel computers utilizing a large number of processors tend tube ...
Xiang, Yonghong
core
Artificial molecular machines and motors—Design and control of nanoscale motion
FEBS Letters, EarlyView.Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Genetics and Molecular BiologyCyclopes didactylus, commonly called silky anteater, is the smallest and least studied of the anteaters. It is an arboreal species occurring in rainforests, ranging from southern Mexico to Central and South America, with an apparently disjoint ...
Raphael Teodoro Franciscani Coimbra +4 more
doaj +1 more source
Frontiers in Genetics, 2015 New mutations leading to structural variation (SV) in genomes — in the form of mobile element insertions, large deletions, gene duplications, and other chromosomal rearrangements — can play a key role in microbial evolution.
Daniel E Deatherage +3 more
doaj +1 more source
There is more: Variation in expletive constructions in Dutch [PDF]
, 2018 This thesis is concerned with expletive clauses in Dutch. An example of such a construction follows in (1). (1) Er loopt iemand op straat. There walks someone on street ‘Someone is walking in the street.’ In this sentence the expletive pronoun er ‘there’
Wesseling, F. +2 more
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