Results 41 to 50 of about 536,557 (280)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Investigation of the dragging stress of aluminium under cyclic loading

Mechanical Engineering Journal
The effect of the variation of the dislocation velocity on the dragging stress of aluminium under cycling loading has been investigated. Hydrogen diffusion around a dislocation was simulated by the finite difference method, and the dragging stress was ...
Shota HASUNUMA, Tomoyuki HAYASE
doaj   +1 more source

Carpal dislocations

Journal of Hand Surgery (European Volume), 2023
Carpal dislocations result from sequential disruption of the complex relationship between the bones and ligaments of the wrist. Injuries to the carpus occur via predictable mechanisms, an understanding of which is critical to identify and treat these frequently missed patterns of injury and to avoid the sequela of chronic instability.
Nathan, Heineman, Dang-Huy, Do, Ann, Golden   +2 more
openaire   +2 more sources

Discrete dislocation dynamics simulations of dislocation-$\theta'$ precipitate interaction in Al-Cu alloys

, 2018
The mechanisms of dislocation/precipitate interaction were studied by means of discrete dislocation dynamics within a multiscale approach. Simulations were carried out using the discrete continuous method in combination with a fast Fourier transform ...
Capolungo, L., Esteban-Manzanares, G., LLorca, J., Papadimitriou, I., Santos-Güemes, R., Segurado, J.   +5 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

How to Rescue of the Dislocated XEN® Gel Stent: A New Surgical Approach on XEN Dislocation and Narrative Review

Journal of Current Ophthalmology
Purpose: To introduce a novel surgical technique for repositioning a dislocated XEN63® gel stent in patients with open-angle glaucoma, to synthesize contemporary findings on complications associated with stent dislocation, and to comment on related ...
Vincenzo Marchese, Viviana Randazzo, Rosanna Badalamenti, Marco Anastasi   +3 more
doaj   +1 more source

Uncommon Dorsal Radiocarpal Fracture Dislocation Complicated With Median Nerve Palsy: Case Report, Review of the Literature, and a New Classification System Guiding the Management

Journal of Orthopaedics, Trauma and Rehabilitation, 2012
We report the case of a 36-year-old lorry driver who sustained left dorsal radiocarpal fracture dislocation and left median nerve injury in a traffic accident in 2010.
Hing-Cheong Wong, Hin-Keung Wong, Kam-Yiu Wong   +2 more
doaj   +1 more source

Traumatic sternoclavicular joint dislocation - A case series and discussion of methods of management

Journal of Orthopaedic Diseases and Traumatology, 2022
Traumatic sternoclavicular (SC) joint injuries account for
V N Ravish, T S Channappa, G Bharath Raju, Manju Jayaram, C L Karan   +4 more
doaj   +1 more source

Minimum energy path for the nucleation of misfit dislocations in Ge/Si(001) heteroepitaxy

, 2016
A possible mechanism for the formation of a 90{\deg} misfit dislocation at the Ge/Si(001) interface through homogeneous nucleation is identified from atomic scale calculations where a minimum energy path connecting the coherent epitaxial state and a ...
Ala-Nissila, Tapio, Granato, Enzo, Jonsson, Hannes, Maras, Emile, Stukowski, Alexander, Trushin, Oleg, Ying, See Chen   +6 more
core   +1 more source