Results 71 to 80 of about 7,286,183 (302)

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Relaxation of thermal stress by dislocation motion in passivated metal interconnects [PDF]

, 2004
The development and relaxation of stress in metal interconnects strained by their surroundings (substrate and passivation layers) is predicted by a discrete dislocation analysis.
Giessen, Erik van der,, Needleman, Alan,, Van der Giessen, E, Erik Van der Giessen, Alan Needleman, Van der Giessen, E; id_orcid, Nicola, Lucia,, Nicola, L, Needleman, A, Lucia Nicola   +9 more
core   +2 more sources

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Plastic damage evolution in structural steel and its non-destructive evaluation

Journal of Materials Research and Technology, 2020
This paper reports the plastic damage evolution in low carbon structural steel and its NDT evaluation. The SEM observations reveal that the voids initiation, growth, coalescence, micro-crack propagation, and macro-crack formation are the main failure ...
Xiao Wang, Jian-Guo Chen, Guo-feng Su, Hua-Ying Li, Chuang Wang   +4 more
doaj   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Modelling the effect of microstructure evolution on the macroscopic behavior of single phase and dual phase steels. Application to sheet forming process [PDF]

, 2017
The aim of this work is to develop a dislocation density based model for IF and DP steels that incorporates details of the microstructure evolution at the grain-size scale. The model takes into account (i) the contribution of the chemical composition for
CARVALHO-RESENDE, Tales, BALAN, Tudor, ABED-MERAIM, Farid, BOUVIER, Salima   +3 more
core  

Dislocation cartography: Representations and unsupervised classification of dislocation networks with unique fingerprints

APL Machine Learning
Detecting structure in data is the first step to arrive at meaningful representations for systems. This is particularly challenging for evolving dislocation networks evolving as a consequence of plastic deformation of crystalline materials.
Benjamin Udofia, Tushar Jogi, Markus Stricker   +2 more
doaj   +1 more source

Impact of Dislocations on Minority Carrier Lifetime in 300-mm Si Wafers During a High Thermal Budget Process

IEEE Journal of the Electron Devices Society
A quantitatively analysis of the impact of process-induced dislocations on minority carrier lifetime in 300-mm Si wafer was presented. High thermal budget processes, such as oxidation and impurity diffusion, are essential in Insulated Gate Bipolar ...
Jiuyang Yuan, Bozhou Cai, Yoshiji Miyamura, Wataru Saito, Shin-Ichi NIshizawa   +4 more
doaj   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source