Results 51 to 60 of about 88,198 (304)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Ductile deformation in alumina ceramics under quasi-static to dynamic contact impact
Materials & Design, 2020 Cr3+ Fluorescence spectroscopy and TEM have been used to study the ductile deformation of alumina ceramics underneath an impact contact. The contact was generated by a spherical tungsten carbide indenter under quasi-static, drop weight and ballistic ...
Robert G. Crookes +2 more
doaj +1 more source
Derivation and study of dynamical models of dislocation densities [PDF]
ESAIM: Proceedings, 2009 In this paper, starting from the microscopic dynamics of isolated dislocations, we explain how to derive formally mean field models for the dynamics of dislocation densities. Essentially these models are tranport equations, coupled with the equations of elasticity.
Hajj, Ahmad El +2 more
openaire +2 more sources
FEBS Open Bio, EarlyView.We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa +2 more
wiley +1 more source
Influence of dislocation density on internal quantum efficiency of GaN-based semiconductors
AIP Advances, 2017 By considering the effects of stress fields coming from lattice distortion as well as charge fields coming from line charges at edge dislocation cores on radiative recombination of exciton, a model of carriers’ radiative and non-radiative recombination ...
Jiadong Yu +9 more
doaj +1 more source
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
, 2008 Effects of interface roughness and dislocation density on the electroluminescence (EL) intensity of InGaN multiple quantum wells (MQWs) are investigated.
Zhang, SM +7 more
core +1 more source
Novel methods for dislocation density estimation in highly compacted tangles
Journal of Materials Research and Technology, 2020 Dislocation lines are usually observed in thin foil images obtained by transmission electron microscopy (TEM). Based on conventional methods involving stereological relationship and line counting, dislocation densities have been calculated in distinct ...
Sergio Neves Monteiro +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source