Results 61 to 70 of about 7,286,183 (302)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Spontaneous dislocation of in-the-bag intraocular lens primarily in cases with prior vitrectomy [PDF]

, 2011
Purpose. To report cases of late onset spontaneous in-the-bag dislocation of the intraocular lens (IOL) and to compare these results with past reports. Methods. We retrospectively studied 21 eyes of 18 patients with dislocation of the entire capsular bag
Tsuiki, Eiko, Eiko Tsuiki, Kiyoshi Suzuma, Yamada, Koki, Suzuma, Kiyoshi, Takeshi Kumagami, Fujikawa, Azusa, Koki Yamada, Uematsu, Masafumi, Makiko Matsumoto, Azusa Fujikawa, Masafumi Uematsu, Kumagami, Takeshi, Takashi Kitaoka, Matsumoto, Makiko, Kitaoka, Takashi   +15 more
core   +1 more source

Influence of dislocation density on internal quantum efficiency of GaN-based semiconductors

AIP Advances, 2017
By considering the effects of stress fields coming from lattice distortion as well as charge fields coming from line charges at edge dislocation cores on radiative recombination of exciton, a model of carriers’ radiative and non-radiative recombination ...
Jiadong Yu, Zhibiao Hao, Linsen Li, Lai Wang, Yi Luo, Jian Wang, Changzheng Sun, Yanjun Han, Bing Xiong, Hongtao Li   +9 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

EBSD-Based Microscopy: Resolution of Dislocation Density [PDF]

, 2009
Consideration is given to the resolution of dislocation density afforded by EBSD-based scanning electron microscopy. Comparison between the conventional Hough- and the emerging high-resolution cross-correlation-based approaches is made. It is illustrated
Brent L. Adams, Joshua Kacher
core   +1 more source

Effect of Interface Roughness and Dislocation Density on Electroluminescence Intensity of InGaN Multiple Quantum Wells

, 2008
Effects of interface roughness and dislocation density on the electroluminescence (EL) intensity of InGaN multiple quantum wells (MQWs) are investigated.
Zhao DG, Wang YT, Zhu JJ, Zhang SM, Yang H(杨辉), Jiang DS, Liu ZS   +6 more
core   +1 more source

A constitutive model optimizing superalloy performance: The interplay of annealing twins, dislocations, and grain boundaries

Journal of Materials Research and Technology
The room temperature mechanical properties and formability of heat-treated ultrathin nickel-based superalloys are significantly influenced by annealing twins, dislocations, and grain boundaries. To elucidate the mechanistic roles of these microstructural
Zongpeng Tian, Rui Zhao, Xinshun Diao, Shan Jiang, Debin Shan, Min Wan   +5 more
doaj   +1 more source

Novel methods for dislocation density estimation in highly compacted tangles

Journal of Materials Research and Technology, 2020
Dislocation lines are usually observed in thin foil images obtained by transmission electron microscopy (TEM). Based on conventional methods involving stereological relationship and line counting, dislocation densities have been calculated in distinct ...
Sergio Neves Monteiro, Luiz Paulo Brandão, Talita Gama de Sousa, Fabio da Costa Garcia Filho   +3 more
doaj   +1 more source