Results 121 to 130 of about 5,552,271 (346)

Autism Spectrum Disorder

Journal of Paediatrics and Child Health, 2018
B. Lo, Felicity Klopper, Elizabeth H Barnes, Katrina Jane Williams   +3 more
semanticscholar   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Esophageal Disorders

American Journal of Gastroenterology, 2010
Kahrilas, Peter J., Smout, André J. P. M.   +1 more
openaire   +4 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Disorder in the nuclear pore complex: The FG repeat regions of nucleoporins are natively unfolded

, 2003
Daniel P. Denning, Samir S. Patel, Vladimir N. Uversky, Anthony L. Fink, Michael Rexach   +4 more
openalex   +1 more source

The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R).

Journal of the American Medical Association (JAMA), 2003
R. Kessler, P. Berglund, Olga V Demler, R. Jin, D. Koretz, K. Merikangas, A. Rush, E. Walters, Philip S. Wang   +8 more
semanticscholar   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Quantification of Conformational Entropy Unravels Effect of Disordered Flanking Region in Coupled Folding and Binding [PDF]

, 2021
Frederik Friis Theisen, Lasse Staby, Frederik Grønbæk Tidemand, Charlotte O’Shea, Andreas Prestel, Martin Willemoës, Birthe B. Kragelund, Karen Skriver   +7 more
openalex   +1 more source

Internet Addiction: The Emergence of a New Clinical Disorder

Cyberpsychology, Behavior, and Social Networking, 1998
K. Young
semanticscholar   +1 more source