Results 101 to 110 of about 2,933,555 (304)

Capillary electrophoresis fragment analysis and clone sequencing in detection of dynamic mutations of spinocerebellar ataxia

Chinese Journal of Contemporary Neurology and Neurosurgery, 2018
Objective To estimate the accuracy and stability of capillary electrophoresis fragment analysis and clone sequencing in detecting dynamic mutations of spinocerebellar ataxia (SCA). Methods Capillary electrophoresis fragment analysis and clone sequencing
Yuan-yuan CHEN, Ying HAO, Jin ZHANG, Xin ZHANG, Kun-ming XIE, Ming DING, Wei-hong GU   +6 more
doaj  

Bipolar disorder

The Lancet
The hallmark of bipolar disorder is hypomania or mania, and the predominant phase of illness is depression. Affecting approximately 40 million individuals worldwide, bipolar disorder is associated with a substantial psychosocial, medical, and financial burden and increased mortality from suicide and other causes.
Balwinder Singh, Holly A Swartz, Alfredo B Cuellar-Barboza, Ayal Schaffer, Tadafumi Kato, Annemieke Dols, Sarah H Sperry, Andrea B Vassilev, Katherine E Burdick, Mark A Frye   +9 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Physical appearance perfectionism explains variance in eating disorder symptoms above general perfectionism [PDF]

, 2015
Physical appearance perfectionism is a domain-specific form of perfectionism comprising two components: hope for perfection and worry about imperfection (Yang & Stoeber, 2012).
Stoeber, Joachim, Yang, Hongfei
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Complexity Analysis of Spontaneous Brain Activity in Attention-Deficit/Hyperactivity Disorder: Diagnostic Implications [PDF]

, 2009
Background: Attention-deficit/hyperactivity disorder (ADHD) is defined as the most common neurobehavioral disorder of childhood, but an objective diagnostic test is not available yet to date.
Biederman, Joseph, García Campos, Natalia, Fernandez, Alberto, Navas, Marta, Escudero, Javier; id_orcid, Gomez, Carlos, Hornero, Roberto, Ortiz, Tomas, Garcia-Campos, Natalia, Zuluaga Arias, María del Pilar, Escudero, Javier, Quintero, Javier, Zuluaga, Pilar, Ortiz Alonso, Tomás   +13 more
core   +1 more source

Psychiatric disorders secondary to neurometabolic disorders

Revista Colombiana de Psiquiatría (English ed.), 2018
Some diseases secondary to inborn errors of metabolism are associated with psychiatric disorders or minor neurological symptoms. The existence of some cases with exclusively psychiatric symptoms represents a diagnostic and therapeutic challenge. The aim of this article is to describe seven treatable neurometabolic disorders that should be taken into ...
Herrera, Paula, Vélez van Meerbeke, Alberto, Bonnot, Olivier   +2 more
openaire   +4 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The use of clozapine in the treatment of bipolar disorder in a patient with clinical comorbidities [PDF]

, 2007
Introduction: Patients with bipolar disorder report impairments of social functioning and the maintenance of relationships. This compromise is often accompanied by executive functioning deficits across mood states and periods of euthymia.
Lagopoulos, Jim, Ceresér, Keila Maria Mendes, Cahill, C, Olley, A L, Brunstein, Miriam Garcia, Frey, B.N., Gonçalves, D.M., Kapczinski, Flávio Pereira, Santin, Aida Maria Pereira, Malhi, G S, Fernandes, B., Shnier, R C, Frey, Benício Noronha, Gomes, Fabiano Alves, Lobato, M.I.   +14 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source