Results 101 to 110 of about 2,856,120 (303)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Predictors of employment in bipolar disorder : a systematic review [PDF]

, 2013
Background Severe work impairment can be present for a considerable proportion of the course of bipolar disorder (BD) and is costly for governments, services and individuals.
Marwaha, Steven, Eleanor Gilbert, Marwaha, Steven; id_orcid, Gilbert, Eleanor, Steven Marwaha   +4 more
core   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

Use of the STAR PROCESS for Children with Sensory Processing Challenges

Open Journal of Occupational Therapy, 2019
Background: This study examined the effectiveness of the STAR PROCESS, an intensive, short-term intervention that combines principles of sensory integration, relationship-based therapy, and parental-therapist collaboration for children with sensory ...
Sarah A. Schoen, Lucy Jane Miller, Stephen Camarata, Andrea Valdez   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Crime and Disorder Audit Process: A Post-Mortem on the First Round [PDF]

, 2002
This paper reviews crime and disorder audits published following the 1998 Crime and Disorder Act. It specifically examines the audits produced in the North-west and North-east of England, by means of a survey of the partnerships as well as an analysis of
Jennings, Jennifer, Hirschfield, Alex, Bowers, Kate J., Jennifer Jennings, Kate Bowers, Alex Hirschfield   +5 more
core   +2 more sources

Capillary electrophoresis fragment analysis and clone sequencing in detection of dynamic mutations of spinocerebellar ataxia

Chinese Journal of Contemporary Neurology and Neurosurgery, 2018
Objective To estimate the accuracy and stability of capillary electrophoresis fragment analysis and clone sequencing in detecting dynamic mutations of spinocerebellar ataxia (SCA). Methods Capillary electrophoresis fragment analysis and clone sequencing
Yuan-yuan CHEN, Ying HAO, Jin ZHANG, Xin ZHANG, Kun-ming XIE, Ming DING, Wei-hong GU   +6 more
doaj  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Bipolar disorder

The Lancet
The hallmark of bipolar disorder is hypomania or mania, and the predominant phase of illness is depression. Affecting approximately 40 million individuals worldwide, bipolar disorder is associated with a substantial psychosocial, medical, and financial burden and increased mortality from suicide and other causes.
Balwinder Singh, Holly A Swartz, Alfredo B Cuellar-Barboza, Ayal Schaffer, Tadafumi Kato, Annemieke Dols, Sarah H Sperry, Andrea B Vassilev, Katherine E Burdick, Mark A Frye   +9 more
openaire   +2 more sources