Results 81 to 90 of about 2,284,468 (268)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Posttraumatic stress disorder : scientific and professional dimensions /

This comprehensive overview of research and clinical practice in PTSD includes new insights into assessment with regard to DSM-5 and ICD-11, discussion of ongoing controversies in the field as to what constitutes safe and effective care, and new research
Ford, Julian D.,author., Grasso, Damion J.,author., Preceded by:Ford, Julian D.Posttraumatic stress disorder.1st ed.2009., Courtois, Christine A.,author., Elhai, Jon D.,author.   +4 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Psychological therapies for people with borderline personality disorder (Review)

, 2006
Background Borderline personality disorder (BPD) is a relatively common personality disorder with a major impact on health services as those affected often present in crisis, often self-harming.
Conor Duggan, Duggan, Connor, Mark Fenton, Adams, Clive E., Adams, Clive, Clive E Adams, Fenton, Mark, Binks, Claire, Lee, Tracey, Lucy McCarthy, Yeadon-Lee, Tracey, Claire Binks, McCarthy, Lucy, Duggan, Conor, Tracey Lee   +14 more
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Working towards an international consensus on criteria for assessing Internet Gaming Disorder: a critical commentary on Petry et al. (2014)

, 2016
This commentary paper critically discusses the recent debate paper by Petry et al. (2014) that argued there was now an international consensus for assessing Internet Gaming Disorder (IGD).
Haagsma, Maria C., Derevensky, J., Kai Müller, Billieux, J., Carras, M., Daria J. Kuss, Joël Billieux, Nicole Prause, Michael Dreier, Coulson, M, Lopez-Fernandez, O, Rooij, A.J., Király, O., King, Daniel, Antonius J. van Rooij, Lopez Fernandez, O., Delfabbro, Paul, Ferguson, Christopher J, Hoff, Rani A, Kuss, Daria, Daniel Kardefelt‐Winther, Nagygyorgy, Katalin, Starcevic, Vladan, Billieux, Joël, Derevensky, Jeffrey, Griffiths, MD, Kuss, Daria J., Vladan Starcevic, Király, O, Paul Delfabbro, Orsolya Király, Király, Orsolya, Olatz Lopez Fernandez, Daniel L. King, Kuss, D.J., Aboujaoude, E, Starcevic, V., Ferguson, CJ, Hoff, R.A., Kuss, Daria J, Nagygyörgy, K, Pallesen, S, Fernandez, Olatz Lopez, Carbonell, Xavier, Ståle Pallesen, Billieux, J, Achab, Sophia, Prause, Nicole, Nagygyorgy, K., King, Daniel L, Pontes, Halley M, Carbonell, X., Hoff, Rani, Zaheer Hussain, Prause, N., Starcevic, V, Thorsten Quandt, Xavier Carbonell, Kardefelt-Winther, D, Carbonell, X, Dreier, Michael, Haagsma, MC, Pontes, Halley, Halley M. Pontes, Lopez Fernandez, Olatz, Maria C. Haagsma, Dreier, M., Kardefelt-Winther, Daniel, Kardefelt‐Winther, D., King, Daniel L., Mark Coulson, Michelle Carras, Müller, Kai, Haagsma, Maria C, van Rooij, Antonius J, Pallesen, S., van Rooij, Tony, Pontes, Halley M., Griffiths, Mark D., Griffiths, Mark D, van Rooij, Antonius J., Haagsma, Maria, Demetrovics, Zsolt, Hoff, RA, Pallesen, Ståle, Rani A. Hoff, Delfabbro, P., Van Rooij, AJ, Coulson, Mark, Hussain, Z., Kuss, DJ, Elias Aboujaoude, Katalin Nagygyorgy, Müller, K, Mark D. Griffiths, Carras, M, Prause, N, Derevensky, J, Aboujaoude, E., Demetrovics, Z., Carras, Michelle, Dreier, M, Hoff, Rani A., Quandt, T, King, D.L., Achab, S, Delfabbro, P, Achab, S., Christopher J. Ferguson, Ferguson, Christopher J., Quandt, T., Griffiths, M.D., Sophia Achab, Aboujaoude, Elias, Demetrovics, Z, Haagsma, M.C., King, DL, Hussain, Z, Zsolt Demetrovics, Jeffrey Derevensky, Coulson, M., Ferguson, Christopher, Ferguson, C.J., Pontes, HM, Müller, K., Hussain, Zaheer, Quandt, Thorsten   +126 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source