Results 71 to 80 of about 2,856,120 (303)
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.Ilaria Chiaradia, Madeline A. Lancasterwiley +1 more sourceDownregulation of the HCN1 Channel Alleviates Anxiety‐ and Depression‐Like Behaviors in Mice With Cerebral Ischemia–Reperfusion Injury by Suppressing the NLRP3 Inflammasome
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Post‐stroke depression (PSD) is a prevalent neuropsychiatric complication of stroke. However, the mechanisms underlying PSD are still unclear.Mei Zhou, Xiaoqin Tao, Kuan Lin, Changlong Leng, Youhua Yang, Yuran Gui, Yaojian Sun, Meiling Zhou, Binlian Sun, Yiyuan Xia, Xiji Shu, Wei Liu +11 moredoaj +1 more sourceHyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky +11 morewiley +1 more sourceJoint analysis of psychiatric disorders increases accuracy of risk prediction for schizophrenia, bipolar disorder, and major depressive disorder [PDF]
, 2015 Genetic risk prediction has several potential applications in medical research and clinical practice and could be used, for example, to stratify a heterogeneous population of patients by their predicted genetic risk.Caesar, Sian, Strohmaier, Jana, Wray, Naomi R., Wiersma D., Puri, Vinay, McGough J. J., Collier, David A., Myin-Germeys, Inez, Absher D., Chen, G. B., Loo, Sandra K., Wijsman E. M., Hallmayer, Joachim, Berrettini, Wade, Paterson A. D., Black D. W., Lathrop, Mark, Leboyer, Marion, Craddock, Nicholas, Lee, S Hong; id_orcid, Maier, R., Pato, Carlos N., Coryell W. H., Franke B., Datta S., Smalley, Susan L., Hansen, Thomas F., Zhang, Peng, Parr JR, Moser G., Santangelo S. L., Pericak-Vance M. A., Mühleisen, Thomas W., Van Os, Jim, Holmans, Peter Alan, Madden P. A. F., Hakonarson, Hakon, Nyholt, Dale R., Krabbendam, Lydia, Moser, Gerhard, State, Matthew, Landen M, De Geus E. J., Roeyers H., Freedman, Robert, Kent, Lindsey, Klauck S. M., Mahon, Pamela B., Gross, Magdalena, Freedman R., Duketis E., Sanders S. J., Nievergelt, Caroline M., Caesar S., Rouleau, Guy, Moreno-De-Luca, Daniel, Elia J., Farmer, Anne E., Hamilton, Steven P., Lesch K. -P., Lawrence J., Hipolito, Maria, Raychaudhuri, Soumya, Vicente, Astrid M., Schalling, Martin, Thapar, Anita, Kwan P., Lee, Sang Hong, Blackwood D. H. R., Craig D. W., Etain, Bruno, Boomsma, Dorret I., Kendler K. S., De Geus, Eco J., et al., Foroud, Tatiana, Gejman, Pablo V., Hickie I. B., Raychaudhuri S., Kennedy, James L., McQuillin, Andrew, Rossin L., Thirumalai S., Van Grootheest G., Ripke, Stephan, Pato, Michele T., Landén, Mikael, Ruderfer, Douglas, Lohoff F. W., Green E. K., Propping P., Maier R, Oliveira G., Kuntsi, Jonna, Li, Jun, Grice D. E., Kahler A. K., van den Oord, Edwin J.C.G., Kendler, Kenneth, other, and, Ribases M., McIntosh, Andrew; id_orcid, Shilling, Paul D., Lord C., Klauck, Sabine M., Kuntsi J., Rasmussen H. B., Vincent J. B., Faraone S. V., Levinson DF, Xu, Wei, Kohli M. A., Banaschewski, Tobias, Agartz I., Gross M., Frank, Josef, Hakonarson H., Tozzi, Federica, Myers R. M., Farmer, Anne, Morrow, Eric M., Wray N. R., Penninx B. W., Gershon E. S., Hong Lee, S., Weissman, Myrna M, Schachar R., Farmer A. E., Levinson, D. F., Doyle, Alysa E., Pato M. T., Santangelo, Susan L., Schellenberg G. D., Leboyer M., Georgieva, Lyudmila, Geschwind D. H., Lewis, Catrin, Coryell, W.H., Middeldorp C. M., Ingason A., Willemsen G., Kuntsi, Jonna; id_orcid, Willsey, A. Jeremy, Watson S. J., Sutcliffe, James, Etain B., Szatmari, Peter, Schwarz, Markus, Smith, Erin N., Psychiatric Genomics Consortium, Cross-Disorder Working Group of the, Hamilton S. P., O'Donovan, Michael Conlon, Medeiros H., Cantor R. M., Amin, Farooq, Visscher, Peter M., Cantor, Rita M., Kenny, Elaine, Hottenga, J.J., Cormand B., Linszen D. H., Smalley S. L., Tzeng J. -Y., McGhee, Kevin A., Vincent, John B., Daly, Mark J., Tzeng, Jung-Ying, Scott L. J., Gill M., Kahn, René S., Middeldorp, C.M., Potash, James B, Stroup, T. Scott, Coryell, William, Hautzinger, Martin, Breen, Gerome, Pickard, Benjamin S., Yu T. W., Olsen, Line, Nurnberger J. I., Vieland V. J., Giegling, Ina, Zandi, Peter P., Smith E. N., Quinn E. M., Tozzi F., Sonuga-Barke, E, Chambert K., Bayés, Mònica, Sullivan P. F., Choudhury, Khalid, McKinney, Rebecca, Medeiros, Helena, Rice, John P., Mowry B. J., Parr J. R., Lewis, Cathryn; id_orcid, Bauer, Michael, Martin, Nicholas G., Hultman, Christina M., Sonuga-Barke, Edmund; id_orcid, Landén, M., Cormican P., Smit J. H., Ingason, Andrés, Kim, Yunjung, Malhotra A. K., Roeder, Kathryn, Betancur C., Nwulia E. A., Shi, J., Cook, Edwin H., Rietschel, Marcella, Wienker T. F., Lande´n, Mikael, Shyn, Stanley I., van den Oord E. J. C. G., Zitman F. G., Van Grootheest, Gerard, Levinson D. F., McGuffin P., Binder E. B., Bayes M., Gill, Michael, Corvin, Aiden, McIntosh A., Owen, Michael J., Young A. H., State M., Akil H., Konte B., Duan, Jubao, Konte, Bettina, Moran J. L., Shi, J. X., Craddock N., Flickinger, Matthew, Nimgaonkar V., McKinney R., Gurling, Hugh, Hoefels, Susanne, Middleton, Lefkos, Schwarz M., Medland, Sarah E., Dawson G., Scott, Laura J., Lieberman J. A., Edenberg, Howard J., Edenberg H. J., Asherson, Philip, Nicol Ferrier I, Mattheisen, Manuel, Buccola N. G., Klei, Lambertus, Andreassen, Ole A., Nikolov I., Malhotra, Anil K., Pericak-Vance, Margaret A., Guan W., Purcell S. M., Nimgaonkar, Vishwajit, Young, Allan H., Kendler KS, Lichtenstein, Paul, Matthews K., Schalling M., Kendler, K. S., Coon H., Kohli, Martin A., Doyle A. E., Maier, Wolfgang, Langstrom N., Montgomery G. W., Franke, B., Backlund L., Smit, Johannes H., Breen G., MacIntyre D. J., Hultman CM, Palotie, Aarno, Hickie, Ian B., Kelsoe J. R., Nievergelt C. M., Heath A. C., Moskvina V., Kenny E., Lin, Dan-Yu, Collier D. A., Backlund, Lena, Shyn S. I., Quested D. J., Weissman, M.M., McCarroll S. A., Lucae S., Buccola, Nancy G., Levinson, Douglas, Holsboer F., Moreno-De-Luca D., Milanova V., Gordon, Scott D., Miranda, Ana, O’Donovan, Michael C., Wray, Naomi, Lencz T., Boehnke, Michael, Meyer, Jobst, Gordon-Smith, Katherine, Reif, Andreas, Kent L., Badner J. A., Lathrop M., Chen, G.B., Smoller, J. W., Amin F., Li J., Landen M., Coryell, W., Binder, Elisabeth B., Hartmann, Annette M., Hipolito M., Murtha M., Robert Cloninger C., Chen G-B, Lencz, Todd, Czamara, Darina, Frisén, Louise, McGrath P. J., Lichtenstein P., Middleton L., Nelson, Stan F., Green, Elaine K., St Clair D., Perlis, Roy H., Scherer S. W., Sanders A. R., Jones, Leslie, de Geus, E.J.C., Grice, Dorothy E., Willemsen, G.; id_orcid, Anjorin, Adebayo, Bettecken, Thomas, Keller, Matthew C., Morken G., Cook E. H., Gallagher L., Ennis S., Treutlein, Jens, Battaglia A., Schumacher J., Weissman MM, Hultman, Christina, Hoogendijk W. J., Cross-Disorder Working Group, of the Psychiatric Genomics Consortium, Myin-Germeys I., Anjorin A., Morrow E. M., Nolen W. A., Kwan, Phoenix, Neale, Benjamin M., Haines, Jonathan L., Grozeva, Detelina, Holmans P. A., Coryell, William H., Ebstein R. P., Freitag C. M., Cormican, Paul, Daly M. J., Cross-Disorder Working Group of the Psychiatric Genomics Consort,, Neale B. M., Frank J., McMahon W. M., McIntosh, Andrew, Kandaswamy, Radhika, Purcell, Shaun M., Friedl M., Buitelaar, J.K., Jones, Lisa, Bergen, Sarah E., Liu, Chunyu, Anney R., Steinhausen H. -C., Bass, Nicholas, Piven J., Fraser C., Chakravarti, Aravinda, Gershon, Elliot S., Rujescu, Dan, Rouleau G., Badner, Judith A., Foroud T., Frisen L., Schatzberg A. F., Bellivier F., Ramos-Quiroga, Josep Antoni, Strauss, John S., Scolnick E., Freimer N. B., Kahn R. S., Xu W., Shilling P. D., Hultman, C. M., Kirov, George K., Zollner S., Cuccaro M. L., Hottenga, Jouke-Jan, Thapar A., Lin D. -Y., Barchas J. D., Posthuma D., Williams, Nigel, Potash J. B., Lewis, Cathryn M., Osby, Urban, Cloninger, C. Robert, Wassink, Thomas H., Lee, S Hong, Jones I., Arking D. E., Fraser, Christine, Banaschewski T., Gurling H., Uhr M., Coryell W., Owen M. J., Dudbridge, Frank, Holmans, Peter A., Nurnberger, John I., Boehnke M., Lee, S. H., Scolnick, Edward, Breen, Gerome; id_orcid, Potash, James, Nöthen, Markus M., Holsboer, Florian, Nyholt, Dale, Klei L., Craig, David W., Van Os J., Henders, Anjali K., Puri V., Maier W., Zandi P. P., Maier, Robert, Scheftner, William A, Långström, Niklas, Datta, Susmita, Melle I., Herms, Stefan, Potash, James B., Wray, Naomi R, Scheftner, William, Propping, Peter, Boomsma D. I., Krasucki R., Krabbendam L., Ebstein, Richard P., Muglia P., McMahon, Francis J., Sklar, Pamela, Ledbetter, David H., Lowe, Jennifer K., Donohoe G. J., Middeldorp, Christel M., Ising M., Schork, Nicholas J., McGhee K. A., Kelsoe, John R., Hottenga J. -J., Young AH, Hoefels S., Azevedo M. H., Hallmayer J., Scheftner, W. A., Schulze T. G., Kendler, Kenneth S, Steinhausen, Hans-Christoph, Biederman, Joseph, Bergen S. E., Rujescu D., Jones L., Scheftner W. A., Hansen T. F., Mahon P. B., Silverman J. M., Ising, Marcus, Medland S. E., Cross-Disorder Working Group of the Psychiatric Genomics Consortium (incl Kent L), Fanous A., Magnusson, Patrik K.E., McMahon F. J., Andreassen O. A., Pimm J., Werge, Thomas, Kähler, Anna K., Weissman, Myrna M., Walsh, Christopher A., Kirov G. K., Shi, Jianxin, Barchas, Jack D., Szelinger, Szabocls, Roeder K., Bellivier, Frank, Olincy, Ann, Visscher P. M., Hultman, C.M., Jamain, Stéphane, Werge T., Georgieva L., Moran, Jennifer L., ?, ?, McMahon, William M., Thompson, Robert C., Maier R., Buxbaum, Joseph D., Guan, Weihua, Barrett, Thomas B., Moser, G., Zhang P., Smoller, J.W., Black, Donald W., Craig I. W., Ripke S, Milanova, Vihra, Landén, Mikael,, Ripke S., Day R., Rehnström, Karola, Day, Richard, Martin C. L., Cichon, Sven, Ribasés, Marta, Coryell W, Lord, Catherine, Wray, N.R., Zammit S., Kirov, George, Nikolov, Ivan, Penninx, Brenda W., Schulze, Thomas G., Todorov, Alexandre A., Cuccaro, Michael L., Keller M. C., Sanders, Alan R., Bass N., Sullivan, Patrick F., Moskvina, Valentina, Oades, Robert D., St Clair, David, Freimer, Nelson B., Bunney, William E., Lee P. H., Byerley, William F., Moser G, Arking, Dan E., Mane, Shrikant M., Weiss L. A., O'Dushlaine C., Lee, Phil H., Smoller J. W., Rice J. P., Absher, Devin, Choudhury K., Craig, Ian, Cross-Disorder Working Group of the Psychiatric Genomics Consortium, Scheftner WA, Chen G. -B., Pimm, Jonathan, Smoller, Jordan, Linszen, Don H., Wienker, Thomas F., Koller, Daniel L., Müller-Myhsok, Bertram, Scheftner, W.A., Ferrier, I. Nicol, Loo S. K., Liu C., Slager, Susan L., Byerley W. F., Maestrini E., Ennis, Sean, Paterson, Andrew D., Breuer R., Lee, S. Hong, Lucae, Susanne, Jamain S., Craig, Ian W., Young, Allan; id_orcid, Korszun, Ania, Casas M., Pergadia, Michele L., Koller D. L., Muglia, Pierandrea, Thirumalai, Srinivasa, Giegling I., McQuillin A., Maestrini, Elena, Flickinger M., Corvin A., Schellenberg, Gerard D., Cichon S., Donohoe, Gary J., Rasmussen, Henrik B., Steffens, Michael, Witt, Stephanie H., Djurovic S., Posthuma, Danielle, Wijsman, Ellen M., Hus V., Martin N. G., Meyer J., Slager S. L., Kendler, Kenneth S., Lesch, Klaus-Peter, Potash, J.B., Asherson P., Dawson, Geraldine, Mattheisen M., Hamshere M. L., Ledbetter D. H., Hultman, Christina M, Cormand, Bru, Duan J., Weissman, M. M., Monaco, Anthony P., Zöllner, Sebastian, Djurovic, Srdjan, Coon, Hilary, Lawrence, Jacob, McLean, Alan W., Barnes M. R., Yu, Timothy W., Sonuga-Barke, Edmund J.S., Williams N., Ripke, S, Silverman, Jeremy M., Franke, Barbara, Jones, Ian Richard, Ophoff, Roel A., Azevedo, Maria H., Chen, G., Pato C. N., Cahn W., Jeremy Willsey A., Todorov A. A., Buitelaar J. K., Schumacher, Johannes, Ophoff R. A., Scott Stroup T., Buitelaar, Jan K., Potash JB, Uhr, Manfred, Meier S., Meier, Sandra, Korszun A., Breuer, René, Bloss, Cinnamon S., Montgomery, Grant W., Smoller, Jordan W., Anney, Richard, Weissman, Myrna, Murtha, Michael, De Haan, Lieuwe, Gordon-Smith K., Quinn, Emma M., Nelson S. F., Hoogendijk, Witte J., Degenhardt, Franziska, Lowe J. K., Rothenberger A., Quested, Digby J., Barrett T. B., Oades R. D., Devlin B., Szatmari P., Asherson, Philip; id_orcid, Nolen, Willem A., Knowles, James A., Grozeva D., Vieland, Veronica J., Thompson R. C., Gejman P. V., De Haan L., Vicente A. M., Perlis R. H., Knowles J. A., Freitag, Christine M., Hautzinger M., Nyholt D. R., Bruggeman, Richard, Ramos-Quiroga J. A., McInnis M. G., Chakravarti A., Meng F., Faraone, Stephen V., Martin, Christa L., Szelinger S., Lee SH, Fombonne E., Palotie A., Degenhardt F., Lawson, William B., Mowry, Bryan J., Devlin, Bernie, Levinson, D.F., Kendler, K.S., Olsen L., Sanders, Stephan J., Miranda A., Scheftner, William A., Potash, J. B., Sutcliffe J., Sergeant, Joseph A., Elia, Josephine, Krasucki, Robert, Morris, Derek W., MacIntyre, Donald J., Witt S. H., Scherer, Stephen W., Hus, Vanessa, Magnusson P. K. E., Duketis, Eftichia, Hamshere, Marian L., Piven, Joseph, Willemsen, Gonneke, Mattingsdal, Morten, Sonuga-Barke E. J. S., Bruggeman R., Nicol Ferrier I., Olincy A., de Geus, E.J.C.; id_orcid, Wiersma, Durk, Wray NR, Morris D. W., Wassink T. H., Madden, Pamela A.F., Hultman C. M., Curtis, David, Rietschel M., Czamara D., Schachar, Russell, Watson, Stanley J., Greenwood T. A., Treutlein J., Cahn, Wiepke, Lohoff, Falk W., Chambert, Kimberly, Biederman J., Hartmann A. M., Melle, Ingrid, Myers, Richard M., Chen, Guo-Bo, Boomsma, D.I.; id_orcid, Rossin, Lizzy, O'Donovan M. C., Poustka F., Crosbie J., Curtis D., Greenwood, Tiffany A., Bailey, Anthony J., Henders A. K., Zammit, Stanley, Friedl, Marion, O’Dushlaine, Colm, Owen, Michael John, Zitman, Frans G., Bloss C. S., Lewis C. M., Buxbaum J. D., Bauer M., Casas, Miguel, McGrath, Patrick J., Bailey A. J., Pergadia M. L., Morken, Gunnar, Levinson, Douglas F, Lee, S.H., Betancur, Catalina, Walsh C. A., Weissman M. M., Steffens M., Mane S. M., Muller-Myhsok B., Nothen M. M., Monaco A. P., Fombonne, Eric, Roeyers, Herbert, Agartz, Ingrid, Rehnstrom K., Weiss, Lauren A., Bettecken T., Strohmaier J., Schatzberg, Alan F., Reif A., Ripke, S., Rothenberger, Aribert, Schork N. J., Shi J, Poustka, Fritz, Wray, N. R., Lee S. H., Gallagher, Louise, Smoller JW, Weissmann, M.M., Kandaswamy R., Levinson, Douglas F., Gordon S. D., Parr, Jeremy R., Lieberman, Jeffrey A., Willemsen, G., Kennedy J. L., Cross-Disorder Working Group of the Psychiatric Genomics, Consortium., Sklar P., Barnes, Michael R., Boomsma, D.I., Lawson W. B., Meng, Fan, Smoller, Jordan W, Osby U., Akil, Huda, McGough, James J., Shi J., Jones, Ian, Muhleisen T. W., Matthews, Keith, Strauss J. S., Haines J. L., Mattingsdal M., Geschwind, Daniel H., Herms S., Sergeant J. A., Oliveira, Guiomar, Nwulia, Evaristus A., Ruderfer D., Battaglia, Agatino, McInnis, Melvin G., Berrettini W., Dudbridge F., Pickard B. S., McGuffin, Peter, McCarroll, Steven A., Bunney W. E., Kim Y., McLean A. W., Crosbie, Jennifer, Heath, Andrew C., Blackwood, Douglas H.R., Fanous, Ayman, Moser, G, Coryell, W, Hultman, CM, Scheftner, WA, Lencz, T., Weissman, MM, +7 additional authors, Smoller, J., Chen, G-B, Potash, JB, Maier, R, Shi, J +858 morecore +3 more sourcesFunctional Diversity and Structural Disorder in the Human Ubiquitination Pathway [PDF]
, 2013 The ubiquitin-proteasome system plays a central role in cellular regulation and protein quality control (PQC). The system is built as a pyramid of increasing complexity, with two E1 (ubiquitin activating), few dozen E2 (ubiquitin conjugating) and several Mainak Guharoy, Rita Pancsa (173029), Pallab Bhowmick, Tompa, Péter, Pallab Bhowmick (416342), Peter Tompa, Bhowmick, Pallab, Pancsa Rita, Guharoy Mainak, Bhowmick Pallab, Tompa Peter, Guharoy, Majnak, Mainak Guharoy (416343), Peter Tompa (38445), Rita Pancsa, Pancsa, Rita +15 morecore +1 more source
