Results 91 to 100 of about 2,856,120 (303)

Pilot study of circulating cell-free mitochondrial DNA in relation to brain structure in youth bipolar disorder

International Journal of Bipolar Disorders
Background Mitochondrial dysfunction is implicated in the neuropathology of bipolar disorder (BD). Higher circulating cell-free mitochondrial DNA (ccf-mtDNA), generally reflecting poorer mitochondrial health, has been associated with greater symptoms ...
Suyi Shao, Yi Zou, Kody G. Kennedy, Mikaela K. Dimick, Ana C. Andreazza, L. Trevor Young, Vanessa F. Goncalves, Bradley J. MacIntosh, Benjamin I. Goldstein   +8 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

fNIRS-Based characterization of adolescent depression using dynamic functional connectivity biomarkers in a verbal fluency task

BMC Psychiatry
Background The human brain is a dynamic neural system with time-varying functional connectivity (FC) strengths between brain regions. Evidence indicates that adolescents with major depressive disorder (MDD) exhibit decreased average FC strength in ...
Tongxin Li, Yeqing Dong, Qingyan Jiao, Lijun Chu, Jianli Qiu, Yanlei Fu, Yongyan Gao, Zhonghui Ma, Xia Sun, Yong Zhang   +9 more
doaj   +1 more source

Disorder! Disorder! Disorder! [PDF]

Acta Crystallographica Section A Foundations and Advances, 2017
Christine M. Beavers, Theocharis Stamatatos   +1 more
openaire   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Wāhine Whaiora: Māori Women's Experiences of Bipolar Disorder and their Pathways to Recovery [PDF]

, 2014
This research examines the unique, lived experiences of wāhine Māori (Māori women) who have been diagnosed with bipolar affective disorder and who are currently living ‘well’.
Harris, Parewahaika Erenora Te Korowhiti
core  

Body image flexibility and embodiment in eating disorders: a mixed-methods approach combining network analysis and pilot exposure protocol

Journal of Eating Disorders
Objective Body image (BI) disturbances are central to the psychopathology of eating disorders (EDs), where body dissatisfaction and disembodiment often co-occur, exacerbating negative body image experiences. We aimed to examine body image flexibility and
Paolo Meneguzzo, Chiara Cazzola, Francesca Buscaglia, Anna Pillan, Filippo Pettenuzzo, Patrizia Todisco   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

A Novel Dual-Frequency Deep Brain Stimulation Paradigm for Parkinson’s Disease

Neurology and Therapy, 2019
Introduction Deep brain stimulation (DBS) of the subthalamic nucleus (STN) using high-frequency (130–185 Hz) stimulation (HFS) is more effective for appendicular than for axial symptoms.
Jessica A. Karl, Bichun Ouyang, Leo Verhagen Metman   +2 more
doaj   +1 more source