Results 141 to 150 of about 2,856,120 (303)
Autism Spectrum Disorder of the Pittsburgh Pocket Psychiatry Series highlights current key topics for this developmental neurobiological disorder: early identification and diagnosis; medical, psychiatric, behavioral, social, educational and language ...
McGonigle, John J. +2 more
core
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Molecular Oncology, EarlyView.This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source
Using Mentalizing and Psychopathy to Explore a Dimensional Model of Antisocial and Borderline Personality Disorder [PDF]
, 2014 Part one of the thesis reviews the literature on whether antisocial personality disorder (ASPD) and psychopathy represent distinct categories. This question was addressed by identifying studies with populations of individuals meeting criteria for ASPD ...
Carlisle, JR
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PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Reconnecting whānau: Pathways to recovery for Māori with bipolar disorder [PDF]
, 2015 While Māori are known to experience a higher burden of mental health and addiction problems compared to non-Māori (Baxter, 2008), little exploratory research has been conducted into Māori experiences of bipolar affective disorder.
Harris, Parewahaika Erenora Te Korowhiti +3 more
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Association of Traffic Air Pollution with Respiratory Symptoms among Adolescents in Yazd, Iran: Based on Global Asthma Network 2020 Cross-sectional Study [PDF]
Journal of Pediatrics ReviewBackground: The relationship between Traffic Air Pollution and asthma symptoms in adolescents is controversial. Objectives: This study investigates the impact of traffic air pollution on asthma symptoms among adolescents aged 13-14 years in Yazd City ...
Abdolhamid Jafarinodoshan +4 more
doaj