Results 161 to 170 of about 5,886,495 (367)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The graded effect of propofol in electrophysiology-guided navigation during deep brain stimulation surgery

npj Parkinson's Disease
Propofol is widely used for general anesthesia (GA) during deep brain stimulation (DBS) surgery targeting the subthalamic nucleus (STN) in Parkinson’s disease (PD), yet its effects on intra-operative spatial navigation, critical for electrode placement ...
G. Issabekov, B. Al-Fatly, M. Mousavi, J. Roediger, R. Köhler, J. Habets, A. L. de Almeida Marcelino, M. S. Tuncer, P. Krause, M. Astalosch, D. Kübler-Weller, C. Spies, P. Spindler, K. Faust, P. Truckenmueller, G. H. Schneider, A. A. Kühn, L. A. Steiner   +17 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Neurocognition in Post-Traumatic Stress Disorder [PDF]

, 2009
The negative behavioural and emotional symptoms of Post-Traumatic Stress Disorder (PTSD) have been extensively reported in the literature. However, much less is known about the neuropsychological and neurobiological characteristics of the disorder.This ...
Newell, Tracey
core  

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Attention Deficit Hyperactivity Disorder (ADHD) and Ethnicity: A Literature Review [PDF]

, 2005
Attention Deficit Hyperactivity Disorder (ADHD) is one of the most expensive mental disorders, costing U.S. citizens $77 billion every year (Reinberg, 2004). Although ADHD effects between 3-7% of U.S.
Bryant, Shanel M.
core   +1 more source

Navigating parenthood in people living with borderline personality disorder: a meta-ethnography

Borderline Personality Disorder and Emotion Dysregulation
Background Emotional dysregulation, impulsivity, and interpersonal difficulties are some of the severe and debilitating symptoms of borderline personality disorder (BPD). Parenting while living with BPD is associated with high levels of parental distress,
Karthika Kasiviswanathan, Jessica Lee, Sathya Rao, Jillian H. Broadbear   +3 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Internet Addiction: The Emergence of a New Clinical Disorder

Cyberpsychology, Behavior, and Social Networking, 1998
K. Young
semanticscholar   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source