Results 171 to 180 of about 5,886,495 (367)
Jolly good nutter: a discursive psychological examination of bipolar disorder in psychotherapeutic interactions [PDF]
, 2007 This dissertation examines how bipolar disorder, a common and disabling psychiatric condition, is made relevant as a participants' concern in a site of massively consequential psychological business - the psychotherapy session.
Bysouth, Don
core +1 more source
npj Mental Health ResearchSubthreshold depression (SD) in adolescents is a prevalent condition associated with significant functional impairment and an increased risk of developing major depressive disorder.
Runhua Wang +18 more
doaj +1 more source
Anxiety Disorders / Somatoform Disorders / Dissociative Disorders [PDF]
Asia-Pacific Psychiatry, 2021 openaire +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Enabling health, independence and wellbeing for patients with bipolar disorder through Personalised Ambient Monitoring [PDF]
This thesis describes the role of mathematical modelling in the evaluation of an innovative automated system of wearable and environmental sensors to monitor the activity patterns of patients with Bipolar Disorder (BD).
Mohiuddin, Syed Golam
core
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source