Results 181 to 190 of about 5,886,495 (367)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Association of Traffic Air Pollution with Respiratory Symptoms among Adolescents in Yazd, Iran: Based on Global Asthma Network 2020 Cross-sectional Study [PDF]

Journal of Pediatrics Review
Background: The relationship between Traffic Air Pollution and asthma symptoms in adolescents is controversial. Objectives: This study investigates the impact of traffic air pollution on asthma symptoms among adolescents aged 13-14 years in Yazd City ...
Abdolhamid Jafarinodoshan, Azam Golzar, Hossein Gharechahi, Nasrin Behniafard, Zahra Nafeiy   +4 more
doaj  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia.

American Journal of Psychiatry, 2007
A. Etkin, T. Wager
semanticscholar   +1 more source

Autism spectrum disorder

Nature Reviews Disease Primers, 2020
C. Lord, T. Brugha, T. Charman, J. Cusack, G. Dumas, T. Frazier, E. Jones, R. Jones, A. Pickles, M. State, J. Taylor, J. Veenstra-VanderWeele   +11 more
semanticscholar   +1 more source

Correction: Secondary outcomes and qualitative findings of an open-label feasibility trial of lisdexamfetamine dimesylate for adults with bulimia nervosa

Journal of Eating Disorders, 2023
Laura Dixon, Sara Bartel, Victoria Brown, Sarrah I. Ali, Susan Gamberg, Andrea Murphy, Katherine L. Brewer, Susan L. McElroy, Allan Kaplan, Abraham Nunes, Aaron R. Keshen   +10 more
doaj   +1 more source

Bipolar Disorder [PDF]

Depression Research and Treatment, 2012
COLOMBO , CRISTINA ANNA, FOSSATI, ANDREA, Colom F.   +2 more
openaire   +3 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Autism Spectrum Disorder What Every Parent Needs to Know [PDF]

Front Cover -- Title Page -- Copyright -- From the Editors -- Contents -- Please Note -- Acknowledgments -- Chapter 1. What Is Autism Spectrum Disorder? -- Chapter 2. What Causes Autism Spectrum Disorder? -- Chapter 3.
Rosenblatt, MD, FAAP, Alan I., Carbone, MD, FAAP, Paul S., Pediatrics, American Academy of.   +2 more
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